Relaxin reduces fibrosis in models of progressive and established hepatic fibrosis

Annals of the New York Academy of Sciences

Volumn 1160, Issue , 2009, Pages 348-349

  Bennett, Robert G ^a,b   Heimann, Dean G ^a   Tuma, Dean J ^a,b  

^a VA NEBRASKA WESTERN IOWA HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Collagen; Hepatic fibrosis; Liver; Relaxin

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; COLLAGEN; RECOMBINANT RELAXIN; SMOOTH MUSCLE ACTIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL MODEL; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CELL ACTIVATION; CONFERENCE PAPER; DRUG EFFECT; DRUG EFFICACY; LIVER CELL; LIVER FIBROSIS; LIVER FUNCTION; MOUSE; NONHUMAN; STELLATE CELL;

EID: 64549143395     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03783.x     Document Type: Conference Paper

References (3)

1. Williams, E.J., R.C. Benyon, N. Trim, et al. 2001. Re-laxin inhibits effective collagen deposition by cultured hepatic stellate cells and decreases rat liver fibrosis in vivo. Gut 49: 577-583.
2. Bennett, R.G., K.K. Kharbanda & D.J. Tuma. 2003. Inhibition of markers of hepatic stellate cell activation by the hormone relaxin. Biochem. Pharmacol. 66: 867-874.
3. Bennett, R.G., S.R. Dalton, K.J. Mahan, et al. 2007. Relaxin receptors in hepatic stellate cells and cirrhotic liver. Biochem. Pharmacol. 73: 1033-1040.