Adult onset atherosclerosis may have its origin in the foetal state in utero

Current Opinion in Lipidology

Volumn 20, Issue 2, 2009, Pages 155-156

  Mukherjee, Sagarika ^a,b  

^a Advanced Medicare Research Institute   (India)

^b 795 D/2 Lake Town ^*  (India)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; FOLIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXIDIZED LOW DENSITY LIPOPROTEIN;

ADULT; ATHEROGENESIS; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; BIRTH WEIGHT; BODY MASS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; DIABETES MELLITUS; DISEASE COURSE; DISEASE PREDISPOSITION; DISORDERS OF CARBOHYDRATE METABOLISM; EDITORIAL; ENVIRONMENTAL EXPOSURE; EPIDEMIOLOGICAL DATA; FETUS; FETUS DEVELOPMENT; HUMAN; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPERTENSION; INFANCY; INSULIN RESISTANCE; LIPID METABOLISM; LIPID PEROXIDATION; LIPID STORAGE; LOW BIRTH WEIGHT; MACROPHAGE; MACROSOMIA; METABOLIC SYNDROME X; MONOCYTE; NON INSULIN DEPENDENT DIABETES MELLITUS; NUTRITION; OBESITY; ONSET AGE; OVERNUTRITION; OXIDATIVE STRESS; PATHOPHYSIOLOGY; POSTNATAL DEVELOPMENT; PREGNANCY DIABETES MELLITUS; PREVALENCE; PRIORITY JOURNAL; PROGENY; RECEPTOR DOWN REGULATION; RISK FACTOR; STEROL METABOLISM; VASCULITIS;

ADULT; AGE OF ONSET; ATHEROSCLEROSIS; BIRTH WEIGHT; FEMALE; HUMANS; HYPERINSULINISM; PREGNANCY; RISK FACTORS; UTERUS;

EID: 64549141177     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOL.0b013e3283295713     Document Type: Editorial

References (21)

1. Palinski W, YamashitaT, Freigang S, Napoli C. Developmental programming: maternal hypercholesterolaemia and immunity influence susceptibility to
2. atherosclerosis. Nutr Rev 2007; 65 (12 Ft 2):S182-S187. This paper discusses on the effects of maternal hypercholesterolaemia in promoting fetal atherosclerosis. It has focused on the influence of inflammation and immune mechanisms on progress of fetal atherosclerosis.
3. Barker DJP, Hales CN, Fall CHD, et al. Type 2 Diabetes mellitus, hypertension and hyperlipidaemia (syndrome x): relation to reduced fetal growth. Diabe- tologia 1993; 36:62-67.
4. Vohr BR, Boney CM. Gestational diabetes: the fore runner for the development of maternal and childhood obesity and metabolic syndrome? J Matern
5. Fetal Neonatal Med 2008; 21:149-157. This paper mentions about effects of gestational diabetes on the offspring's risk for development of cardiovascular disease in later life.
6. Metzger BE. Long-term outcomes in mothers diagnosed with gestational diabetes mellitus and their offspring. Clin Obstet Gynecol 2007; 50:972- 979.
7. Yajnik CS, Deshmukh US. Maternal nutrition, intrauterine programming and consequential risks in the offspring. Rev Endocr Metab Disord 2008; 9:203-
8. 211; Epub 2008 Jul 26. This paper discusses on the effects of maternal nutrition on effects of fetal programming of future metabolic fisorders nad focuses on aspects of micro- nutrients.
9. Singhal A, Wells J, Cole TJ, et al. Programming of lean body mass: a link between birth weight, obesity and cardiovascular disease? Am J Clin Nutr 2003; 77:726-730.
10. Ong KK, Dunger DB. Perinatal growth failure: road to obesity, insulin resistance and cardiovascular disease in adults. Best Pract Res Clin Endocrinol Metab 2002; 16:191 -207.
11. Napoli C, Witztum JL, de Nigris F, et al. Intracranial arteries of human fetuses are more resistant to hypercholesterolemia-induced fatty streak formation than extracranial arteries. Circulation 1999; 99:2003-2010.
12. Poston L Influences of maternal nutritional status on vascular function in the offspring. Curr Drug Targets 2007; 8:914-922. This paper discusses about intrauterine influence on the future development of cardiovascular disease. There are detailed discussions about malfunctioning of arterial endothelial layer in association with both overnutrition and undernutrition of the mother.
13. Pathobiological Determinants of Atherosclerosis in Youths (PDAY) Research Group Natural history of aortic and coronary atherosclerotic lesions in youth. Findings from the PDAY study. Arterioscler Thromb 1993; 13: 1291 -1298.
14. Napoli C, D' Armiento FP, Mancini FP, et al. Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia: intimal accumulation of LDL and its oxidation precede monocyte recruitment into early atherosclerotic lesions. J Clin Invest 1997; 100:2680-2690.
15. Woollett SA. The origins and roles of cholesterol and fatty acids in the fetus. Curr Opin Lipidol 2001; 12:305-312.
16. Napoli C, Glass CK, Witztum JL, et al. Influence of maternal hypercholesterolaemia during pregnancy on progression of early atherosclerotic lesions in childhood: Fate of Early Lesions in Children (FELIC) study. Lancet 1999; 354:1234-1241.
17. de Nigris F, Youssef T, Ciafre SA, et al. Evidence for oxidative activation of c-Myc-dependent nuclear signaling pathways in cultured human coronary SMC and in early atherosclerotic lesions of WHHL rabbits: protective effects of vitamin E. Circulation 2000; 102:2111-2117.
18. Collins T, Cybulsky M. NF-κB: pivotal mediator or innocent bystander in atherogenesis? J Clin Invest 2001; 107:255-264.
19. Radunovic N, Kuczynski E, Rosen T, et al. Plasma apolipoprotein A-l and B concentrations in growth-retarded fetuses: a link between low birth weight and adult atherosclerosis. J Clin Endocrinol Metab 2000; 85:85-88.
20. Pallinski W, Napoli C. The fetal origins of atherosclerosis: maternal hyper- cholesterolemia, and cholesterol-lowering or antioxidant treatment during
21. pregnancy influence in utero programming and postnatal susceptibility to atherogenesis. The FASEB Journal 2002; 16:1348-1360.