Effect of TZP-201, a novel motilin receptor antagonist, in the colon of the musk shrew (Suncus murinus)

Journal of Pharmacy and Pharmacology

Volumn 61, Issue 3, 2009, Pages 367-373

  Venkova, Kalina ^a,b   Thomas, Helmut ^c   Fraser, Graeme L ^c   Meerveld, Beverley Greenwood Van ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^c Tranzyme Pharma Inc   (Canada)

Author keywords

Colonic contraction; Motilin; Motilin receptor antagonist tzp 201; Musk shrew

Indexed keywords

ATROPINE; CARBACHOL; MOTILIN; MOTILIN RECEPTOR ANTAGONIST; MOTILIN[13 LEUCINE]; SPASMOLYTIC AGENT; TETRODOTOXIN; TZP 201; UNCLASSIFIED DRUG; HORMONE RECEPTOR; MOTILIN RECEPTOR; NEUROPEPTIDE RECEPTOR;

ANIMAL TISSUE; ARTICLE; COLON ABSORPTION; COLON MOTILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; ELECTROLYTE TRANSPORT; IC 50; INTESTINE MOTILITY; INTESTINE MUSCLE; NONHUMAN; SHREW; SMOOTH MUSCLE RELAXATION; STOMACH MOTILITY; STOMACH MUSCLE; WATER TRANSPORT; ANIMAL; COLON; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION; INTESTINE MUCOSA; MALE; METABOLISM; MUSCLE CONTRACTION; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALS; BIOLOGICAL TRANSPORT; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; INTESTINAL MUCOSA; MALE; MOTILIN; MUSCLE CONTRACTION; RECEPTORS, GASTROINTESTINAL HORMONE; RECEPTORS, NEUROPEPTIDE; SHREWS;

EID: 64549135390     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp/61.03.0012     Document Type: Article

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