Novel isothiourea derivatives as potent neuroprotectors and cognition enhancers: synthesis, biological and physicochemical properties

Journal of Medicinal Chemistry

Volumn 52, Issue 7, 2009, Pages 1845-1852

  Perlovich, German L ^a,b   Proshin, Alexey N ^b   Volkova, Tatyana V ^a   Kurkov, Sergey V ^a   Grigoriev, Vlaimir V ^b   Petrova, Ludmila N ^b   Bachurin, Sergey O ^b  

^a INSTITUTE OF SOLUTION CHEMISTRY   (Russian Federation)

^b INSTITUTE OF PHYSIOLOGICALLY ACTIVE COMPOUNDS   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

3 ALLYL 1,1 DIBENZYL 2 ETHYLISOTHIOUREA HYDROBROMIDE; 3 ALLYL 1,1 DIBENZYL 2 ETHYLISOTHIOUREA HYDROCHLORIDE; 3 ALLYL 1,1 DIBENZYL 2 ETHYLISOTHIOUREA HYDROIODIDE; CYCLOTHIAZIDE; GLUTAMIC ACID; KAINIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; NOOTROPIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BRAIN CORTEX; COGNITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG STRUCTURE; DRUG SYNTHESIS; NEUROPROTECTION; NONHUMAN; PHYSICAL CHEMISTRY; PURKINJE CELL; RAT;

1-OCTANOL; ALLYL COMPOUNDS; ANIMALS; BRAIN; CALCIUM; CRYSTALLOGRAPHY, X-RAY; DRUG STABILITY; DRUG SYNERGISM; LIGANDS; NEURONS; NEUROPROTECTIVE AGENTS; NOOTROPIC AGENTS; PATCH-CLAMP TECHNIQUES; PURKINJE CELLS; RATS; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; SYNAPTOSOMES; TEMPERATURE; THERMODYNAMICS; THIOUREA; WATER;

EID: 64549110888     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm8012882     Document Type: Article

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