Towards an understanding of the molecular mechanism of solvation of drug molecules: A thermodynamic approach by crystal lattice energy, sublimation, and solubility exemplified by hydroxybenzoic acids

Journal of Pharmaceutical Sciences

Volumn 95, Issue 7, 2006, Pages 1448-1458

  Perlovich, German L ^a,b   Volkova, Tatyana V ^b   Bauer Brandl, Annette ^a  

^a UNIVERSITY OF TROMSØ   (Norway)

^b INSTITUTE OF SOLUTION CHEMISTRY   (Russian Federation)

Author keywords

2 , 3 and 4 hydroxybenzoic acids; Packing crystal lattice energy; Solubility; Solvation; Specific and nonspecific interactions; Sublimation thermodynamics

Indexed keywords

3 HYDROXYBENZOIC ACID; 4 HYDROXYBENZOIC ACID; HEXANE; HYDROXYBENZOIC ACID DERIVATIVE; OCTANOL; SALICYLIC ACID;

ARTICLE; CRYSTAL STRUCTURE; DEFENSE MECHANISM; DIFFRACTION; DRUG SOLUBILITY; ENTHALPY; EVAPORATION; GEOMETRY; HYDROGEN BOND; MOLECULAR MECHANICS; SOLVATION; TEMPERATURE DEPENDENCE; THERMODYNAMICS; VAPOR PRESSURE; VAPORIZATION;

EID: 33745892928     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20611     Document Type: Article

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