Relaxin signaling in uterine fibroids

Annals of the New York Academy of Sciences

Volumn 1160, Issue , 2009, Pages 374-378

  Li, Zhen ^a,b   Burzawa, Jennifer K ^a   Troung, Anne ^a   Feng, Shu ^a   Agoulnik, Irina U ^a   Tong, Xiaowen ^b   Anderson, Matthew L ^a   Kovanci, Ertug ^a   Rajkovic, Aleksandar ^a   Agoulnik, Alexander I ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TONGJI UNIVERSITY   (China)

Author keywords

INSL3; Leiomyoma; Phospho SMAD2; Relaxin; Transforming growth factor

Indexed keywords

CAVEOLIN 1; DESMIN; HORMONE RECEPTOR; NCOR1 RECEPTOR; NCOR2 RECEPTOR; RELAXIN; RXFP1 RECEPTOR; RXFP2 RECEPTOR; SMAD2 PROTEIN; STEROID RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; CONFERENCE PAPER; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LEIOMYOMA; NONHUMAN; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

RATTUS;

EID: 64549108513     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2008.03803.x     Document Type: Conference Paper

References (11)

1. Walker, C.L. & E.A. Stewart. 2005. Uterine fibroids: The elephant in the room. Science 308: 1589-1592.
2. Sozen, I. & A. Arici. 2002. Interactions of cytokines, growth factors, and the extracellular matrix in the cellular biology of uterine leiomyomata. Fertil. Steril. 78: 1-12.
3. Sherwood, O.D. 2004. Relaxin's physiological roles and other diverse actions. Endocr. Rev. 25: 205-234.
4. Masterson, R., T.D. Hewitson, K. Kelynack, et al. 2004. Relaxin down-regulates renal fibroblast function and promotes matrix remodelling in vitro. Nephrol. Dial. Transplant. 19: 544-552.
5. Mookerjee, I., E.N. Unemori, X.J. Du, et al. 2005. Relaxin modulates fibroblast function, collagen production, and matrix metalloproteinase-2 expression by cardiac fibroblasts. Ann. N. Y. Acad. Sci. 1041: 190-193.
6. Unemori, E.N., L.B. Pickford, A.L. Salles, et al. 1996. Relaxin induces an extracellular matrix-degrading phenotype in human lung fibroblasts in vitro and inhibits lung fibrosis in a murine model in vivo. J. Clin. Investig. 98: 2739-2745.
7. Unemori, E.N., L.S. Beck, W.P. Lee, et al. 1993. Human relaxin decreases collagen accumulation in vivo in two rodent models of fibrosis. J. Investig. Dermatol. 101: 280-285.
8. Chegini, N., X. Luo, L. Ding, et al. 2003. The expression of Smads and transforming growth factor beta receptors in leiomyoma and myometrium and the effect of gonadotropin releasing hormone analogue therapy. Mol. Cell. Endocrinol. 209: 9-16.
9. Chegini, N., C. Ma, J. Davis, et al. 1999. Differential expression of transforming growth factor-beta 1 and transforming growth factor-beta receptors in my-ometrium of women with failed induction of labor, no labor, and preterm labor. J. Soc. Gynecol. Investig. 6: 258-263.
10. Massagué, J., S.W. Blain & R.S. Lo. 2000. TGFZβ signaling in growth control, cancer, and heritable disorders. Cell 103: 295-309.
11. Heeg, M.H., M.J. Koziolek, R. Vasko, et al. 2005. The antifibrotic effects of relaxin in human renal fibroblasts are mediated in part by inhibition of the Smad2 pathway. Kidney Int. 68: 96-109.