Computer-aided analysis of cell interactions under dynamic flow conditions

Experimental Dermatology

Volumn 18, Issue 3, 2009, Pages 238-245

  Giegold, Oliver ^a   Ludwig, Ralf J ^a   Hardt, Katja ^a   Will, Jutta ^a   Schön, Michael P ^b,c   Oostingh, Gertie J ^b,d   Pfeilschifter, Josef M ^a   Boehncke, Wolf Henning ^a   Radeke, Heinfried H ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d UNIVERSITY OF SALZBURG   (Austria)

Author keywords

Flow chamber; Inflammation; Intravital microscopy; Leucocyte extravasation; Rolling

Indexed keywords

ANIMAL CELL; ARTICLE; AUTOMATION; CELL INTERACTION; COMPUTER AIDED DESIGN; COMPUTER ANALYSIS; CONTROLLED STUDY; DATA ANALYSIS SOFTWARE; ENDOTHELIUM CELL; HIGH THROUGHPUT SCREENING; HISTOGRAM; HUMAN; HUMAN CELL; INTERMETHOD COMPARISON; LEUKOCYTE; LEUKOCYTE MIGRATION; MOUSE; NONHUMAN; PROCESS OPTIMIZATION; REPRODUCIBILITY; SKIN INFLAMMATION; VALIDATION PROCESS;

EID: 64549104304     PISSN: 09066705     EISSN: 16000625     Source Type: Journal    
DOI: 10.1111/j.1600-0625.2008.00793.x     Document Type: Article

References (18)

1. Radeke H H, Ludwig R J, Boehncke W H. Experimental approaches to lymphocyte migration in dermatology in vitro and in vivo. Exp Dermatol 2005: 14: 641-666.
2. Springer T A. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 1994: 76: 301-314.
3. von Andrian U H, Mackay C R. T-cell function and migration. Two sides of the same coin. N Engl J Med 2000: 343: 1020-1034.
4. Alon R, Chen S, Fuhlbrigge R et al. The kinetics and shear threshold of transient and rolling interactions of L-selectin with its ligand on leukocytes. Proc Natl Acad Sci U S A 1998: 95: 11631-11636.
5. Feizi T. Carbohydrate ligands for the leukocyte-endothelium adhesion molecules, selectins. Results Probl Cell Differ 2001: 33: 201-223.
6. Gerard C, Rollins B J. Chemokines and disease. Nat Immunol 2001: 2: 108-115.
7. Rubant S, Ludwig R J, Pfeffer J et al. Eukaryotic expression of the broad-spectrum chemokine receptor antagonist vMIP-II and its effects on T-cell function in vitro and in vivo. Exp Dermatol 2006: 15: 634-642.
8. Homey B, Alenius H, Muller A et al. CCL27-CCR10 interactions regulate T cellmediated skin inflammation. Nat Med 2002: 8: 157-165.
9. Schon M P, Zollner T M, Boehncke W H. The molecular basis of lymphocyte recruitment to the skin: Clues for pathogenesis and selective therapies of inflammatory disorders. J Invest Dermatol 2003: 121: 951-962.
10. Boehncke W H, Schon M P. Interfering with leukocyte rolling - a promising therapeutic approach in inflammatory skin disorders? Trends Pharmacol Sci 2003: 24: 49-52.
11. Boehncke W H, Ochsendorf F R, Noll S et al. Efficacy of the fully human monoclonal antibody MOR102 (#5) against intercellular adhesion molecule 1 in the psoriasis-severe combined immunodeficient mouse model. Br J Dermatol 2005: 153: 758-766.
12. Ramos C L, Kunkel E J, Lawrence M B et al. Differential effect of E-selectin antibodies on neutrophil rolling and recruitment to inflammatory sites. Blood 1997: 89: 3009-3018.
13. Dunne J L, Ballantyne C M, Beaudet A L, Ley K. Control of leukocyte rolling velocity in TNF-alpha-induced inflammation by LFA-1 and Mac-1. Blood 2002: 99: 336-341.
14. Lawrence M B, Springer T A. Neutrophils roll on E-selectin. J Immunol 1993: 151: 6338-6346.
15. DiVietro J A, Brown D C, Sklar L A et al. Immobilized stromal cell-derived factor-1alpha triggers rapid VLA-4 affinity increases to stabilize lymphocyte tethers on VCAM-1 and subsequently initiate firm adhesion. J Immunol 2007: 178: 3903-3911.
16. Chien S, Sung K L, Schmid-Schonbein G W et al. Rheology of leukocytes. Ann N Y Acad Sci 1987: 516: 333-347.
17. Ley K, Gaehtgens P. Endothelial, not hemodynamic, differences are responsible for preferential leukocyte rolling in rat mesenteric venules. Circ Res 1991: 69: 1034-1041.
18. Boehncke W H, Schon M P, Giromolomi G et al. Leukocyte extravasation as a target for anti-inflammatory therapy - which molecule to choose? Exp Dermatol 2005: 14: 70-80.