Long-term nicotine treatment reduces cerebral cortical vasodilation mediated by α4β2-like nicotinic acetylcholine receptors in rats

European Journal of Pharmacology

Volumn 609, Issue 1-3, 2009, Pages 100-104

  Uchida, Sae ^a   Hotta, Harumi ^a   Kawashima, Koichiro ^b  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b MUSASHINO UNIVERSITY   (Japan)

Author keywords

4 2 like nicotinic receptor; (Rat); Chronic nicotine; Cortical cerebral blood flow; Vasodilation

Indexed keywords

BUNGAROTOXIN RECEPTOR; DIHYDRO BETA ERYTHROIDINE; METHYLLYCACONITINE; NICOTINE; NICOTINIC RECEPTOR ALPHA4BETA2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG MEGADOSE; FRONTAL CORTEX; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

ACONITINE; ANIMALS; CEREBRAL CORTEX; CEREBROVASCULAR CIRCULATION; DIHYDRO-BETA-ERYTHROIDINE; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; NICOTINE; NICOTINIC ANTAGONISTS; RATS; RATS, WISTAR; RECEPTORS, NICOTINIC; REGIONAL BLOOD FLOW; TIME FACTORS; VASODILATION;

EID: 64549099350     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2009.03.016     Document Type: Article

References (28)

1. Araujo D.M., Lapchak P.A., Meaney M.J., Collier B., and Quirion R. Effects of aging on nicotinic and muscarinic autoreceptor function in the rat brain: relationship to presynaptic cholinergic markers and binding sites. J. Neurosci. 10 (1990) 3069-3078
2. Arnold H.M., Nelson C.L., Sarter M., and Bruno J.P. Sensitization of cortical acetylcholine release by repeated administration of nicotine in rats. Psychopharmacology 165 (2003) 346-358
3. 3H]nicotine binding sites in human brain. J. Neurochem. 50 (1988) 1243-1247
4. Besson M., Granon S., Mameli-Engvall M., Cloëz-Tayarani I., Maubourguet N., Cormier A., Cazala P., David V., Changeux J.P., and Faure P. Long-term effects of chronic nicotine exposure on brain nicotinic receptors. Proc. Natl. Acad. Sci. 104 (2007) 8155-8160
5. Biesold D., Inanami O., Sato A., and Sato Y. Stimulation of the nucleus basalis of Meynert increases cerebral cortical blood flow in rats. Neurosci. Lett. 98 (1989) 39-44
6. Dani J.A., and Heinemann S. Molecular and cellular aspects of nicotine abuse. Neuron 16 (1996) 905-908
7. Dwoskin L.P., and Crooks P.A. Competitive neuronal nicotinic receptor antagonists: a new direction for drug discovery. J. Pharmacol. Exp. Ther. 298 (2001) 395-402
8. 125I]epibatidine in adrenal gland, superior cervical ganglia, pineal or retina. J. Neurochem. 85 (2003) 1237-1246
9. Grilli M., Parodi M., Raiteri M., and Marchi M. Chronic nicotine differentially affects the function of nicotinic receptor subtypes regulating neurotransmitter release. J. Neurochem. 93 (2005) 1353-1360
10. Hernandez C.M., and Terry Jr. A.V. Repeated nicotine exposure in rats: effects on memory function, cholinergic markers and nerve growth factor. Neuroscience 130 (2005) 997-1012
11. Hotta H., Uchida S., and Kagitani F. Effects of stimulating the nucleus basalis of Meynert on blood flow and delayed neuronal death following transient ischemia in the rat cerebral cortex. Jpn. J. Physiol. 52 (2002) 383-393
12. Hulihan-Giblin B.A., Lumpkin M.D., and Kellar K.J. Effects of chronic administration of nicotine on prolactin release in the rat: inactivation of prolactin response by repeated injections of nicotine. J. Pharmacol. Exp. Ther. 252 (1990) 21-25
13. Linville D.G., Williams S., Raszkiewicz J.L., and Arneric S.P. Nicotinic agonists modulate basal forebrain control of cortical cerebral blood flow in anesthetized rats. J. Pharmacol. Exp. Ther. 267 (1993) 440-448
14. Marks M.J., Grady S.R., and Collins A.C. Downregulation of nicotinic receptor function after chronic nicotine infusion. J. Pharmacol. Exp. Ther. 266 (1993) 1268-1276
15. Nguyen H.N., Rasmussen B.A., and Perry D.C. Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment. J. Neurochem. 90 (2004) 40-49
16. Nordberg A., Alafuzoff I., and Winblad B. Nicotinic and muscarinic subtypes in the human brain: changes with aging and dementia. J. Neurosci. Res. 31 (1992) 103-111
17. Nott A., and Levin E.D. Dorsal hippocampal alpha7 and alpha4beta2 nicotinic receptors and memory. Brain Res. 1081 (2006) 72-78
18. Perry D.C., Dávila-García M.I., Stockmeier C.A., and Kellar K.J. Increased nicotinic receptors in brains from smokers: membrane binding and autoradiography studies. J. Pharmacol. Exp. Ther. 289 (1999) 1545-1552
19. Picciotto M.R., Caldarone B.J., Brunzell D.H., Zachariou V., Stevens T.R., and King S.L. Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol. Ther. 92 (2001) 89-108
20. Rao T.S., Reid R.T., Correa L.D., Santori E.M., Gardner M.F., Sacaan A.I., Lorrain D., and Vernier J.-M. In vivo pharmacological characterization of (+/-)-4-[2-(1-methyl-2-pyrrolidinyl)ethyl]thiophenol hydrochloride (SIB-1553A), a novel cholinergic ligand: microdialysis studies. Brain Res. 986 (2008) 71-81
21. Rezvani A.H., and Levin E.D. Cognitive effects of nicotine. Biol. Psychiatry 49 (2001) 258-267
22. Sanderson E.M., Drasdo A.L., McCrea K., and Wonnacott S. Upregulation of nicotinic receptors following continuous infusion of nicotine is brain-region-specific. Brain Res. 617 (1993) 349-352
23. Sato A., and Sato Y. Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain. Neurosci. Res. 14 (1992) 242-274
24. Solinas M., Scherma M., Fattore L., Stroik J., Wertheim C., Tanda G., Fratta W., and Goldberg S.R. Nicotinic alpha 7 receptors as a new target for treatment of cannabis abuse. J. Neurosci. 27 (2007) 5615-5620
25. Uchida S., Kagitani F., Nakayama H., and Sato A. Effect of stimulation of nicotinic cholinergic receptors on cortical cerebral blood flow and changes in the effect during aging in anesthetized rats. Neurosci. Lett. 228 (1997) 203-206
26. Vann R.E., James J.R., Rosecrans J.A., and Robinson S.E. Nicotinic receptor inactivation after acute and repeated in vivo nicotine exposures in rats. Brain Res. 1086 (2006) 98-103
27. Wang Y., Sherwood J.L., Miles C.P., Whiffin G., and Lodge D. TC-2559 excites dopaminergic neurones in the ventral tegmental area by stimulating alpha4beta2-like nicotinic acetylcholine receptors in anaesthetised rats. Br. J. Pharmacol. 147 (2006) 379-390
28. Wonnacott S. The paradox of nicotinic acetylcholine receptor upregulation by nicotine. Trends Pharmacol. Sci. 11 (1990) 216-219