Probing the human brain with stimulating electrodes: The story of Roberts Bartholow's (1874) experiment on Mary Rafferty

Brain and Cognition

Volumn 70, Issue 1, 2009, Pages 92-115

  Harris, Lauren Julius ^a   Almerigi, Jason B ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

Cortical excitability; Electrical stimulation; Ethics; History; Human brain; Localisation of function; Roberts Bartholow; Vivisection

Indexed keywords

ARTICLE; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; CAREER; EMPIRICAL RESEARCH; HUMAN; MEDICAL ETHICS; MEDICAL SPECIALIST; MICROELECTRODE; MOTOR PERFORMANCE; NERVE CELL EXCITABILITY; NEUROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BRAIN; DURA MATER; ELECTRIC STIMULATION; ELECTROLYSIS; EQUIPMENT AND SUPPLIES; FUNCTIONAL LATERALITY; HISTORY, 19TH CENTURY; HUMANS; MOTOR ACTIVITY; NEUROPHYSIOLOGY; UNITED STATES; VIVISECTION;

EID: 64449083959     PISSN: 02782626     EISSN: 10902147     Source Type: Journal    
DOI: 10.1016/j.bandc.2009.01.008     Document Type: Article

References (142)

1. Akert K., and Welker W.I. Problems and methods of anatomical localization. In: Sheer D.E. (Ed). Electrical stimulation of the brain: An interdisciplinary survey of neurobehavioral integrative systems (1961), University of Texas Press, Austin, Texas 251-260
2. American Neurological Association. (2000). .
3. Anon. Hitzig on Dr. Ferrier's experiments. The Medical Times and Gazette (1874) 104 January 24
4. Anon. Quarterly summary of the improvements and discoveries in the medical sciences. Anatomy and physiology. 1. Functions of the brain. The American Journal of the Medical Sciences 67 April (1874) 515-517
5. Anon. Quarterly summary of the improvements and discoveries in the medical sciences. Anatomy and Physiology. 1. Bartholow's experiments on the human brain. The American Journal of the Medical Sciences 68 July (1874) 235-236
6. Anon. Researches on the brain (a) by Dr. Eduard Hitzig. No. II for 1874. The Medical Times and Gazette (1874) 17-18 July 4
7. Anon. Experiments on the human subject [Editorial]. British Medical Journal (1874) 687 May 23, i
8. Anon. Dr. Bartholow's experiments [Editorial]. The British Medical Journal (1874) 723 May 30, i
9. Anon. Cerebral thermometry. The Medical Times and Gazette (1877) 311-312 [Volume II for 1877, September 15; October 6, 397-398]
10. Anon. The British Medical Journal (1879) 680 May 3
11. Anon. Antagonism between opium and belladonna. The American Journal of the Medical Sciences 81 January (1881) 281
12. Anon. Review of D. Ferrier, the functions of the brain. The British Medical Journal 2 (1886) 1104-1105 [2nd ed.]
13. Anon (1932). Biography of Roberts Bartholow in The National Cyclopaedia of American Biography (Vol. 22). New York: James T. White & Co. pp. 212-213.
14. Anon (2001). Roberts Bartholow. Rivers/Briel Family Tree. Accessed 02.07.01.
15. Applebaum P.A., and Roth L.H. Competency to consent in research: A psychiatric overview. Archives of General Psychiatry 39 (1982) 951-958
16. R. B. (1881). Review of R Bartholow, a treatise on the practice of medicine, for the use of students and practitioners, 1880. The American Journal of the Medical Sciences, 81(January), 209-220.
17. Baker, R., & Emanuel, L. (2000). The efficacy of professional ethics. The AMA code of ethics in historical and current perspective. Special Supplement/A global profession: Medical values in China and the United States, Hastings Center Report, 3, No. 4, S13-S17.
18. Bartholow R. A manual of instructions for enlisting and discharging soldiers with the medical examination of recruits (1862), J.P. Lippincott, Philadelphia
19. Bartholow R. On spermatorrheoea: Its causes, symptoms, pathology, prognosis, diagnosis, and treatment (1866), W. Wood & Co, New York [1871, 2nd ed.]
20. Bartholow R. The principles and practice of disinfection (1867), R.W. Carroll & Co, Cincinnati
21. Bartholow R. A manual of hypodermic medication: The treatment of diseases by the hypodermic or subcutaneous method (1869), J.P. Lippincott & Co, Philadelphia [1873, new ed.]
22. Bartholow, R. (1871). Bromides, their physiological effects and therapeutic uses. British Medical Society Fiske Fund Prize Dissertation. Providence, Rhode Island: S.S. Rider & Bros.
23. Bartholow R. The electrical room of the Good Samaritan Hospital. The Clinic, Cincinnati 2 (1872) 86-89 [February 24]
24. Bartholow R. Experimental therapeutics. Introductory address. Quoted in "Medical College of Ohio". Cincinnati Lancet Observer 15 New Series (1872) 635-636
25. Bartholow R. Experimental investigations into the functions of the human brain. The American Journal of the Medical Sciences 134 (1874) 305-313
26. Bartholow R. Experiments on the functions of the human brain. The British Medical Journal (1874) 727 [Letter to the Editor]May 30, i
27. Bartholow R. A practical treatise on materia medica and therapeutics (1876), D. Appleton and Company, New York
28. Bartholow R. The degree of certainty in therapeutics. Transactions of the Medical and Chirurgical Faculty of the State of Maryland (1876) 33-50
29. Bartholow R. A contribution to the study of animal temperature. Preliminary note. The American Journal of the Medical Sciences 73 January (1877) 36-39
30. Bartholow R. Dr. Eugène Dupuy (Paris) on the physiology of the brain [Letter to the Editor]. The Medical Times and Gazette (1877) 371-372 [Vol. II for 1877, September 29]
31. Bartholow R. On the treatment of certain forms of phthisis pulmonalis by rest, and the internal administration of atropia. The American Journal of the Medical Sciences 73 April (1877) 436-446
32. Bartholow R. The present state of therapeutics. Introductory Lecture, 54th session, Jefferson Medical College, October 1. Medical Record 16 (1879) 337-342
33. Bartholow R. A treatise on the practice of medicine, for the use of students and practitioners (1880), D. Appleton and Co, New York
34. Bartholow R. Medical electricity: A practical treatise on the applications of electricity to medicine and surgery (1881), Henry C. Lea's Son & Co, Philadelphia
35. Bartholow R. On the antagonism between medicines and between remedies and diseases. Being the Cartwright lectures for the year 1880 (1881), D. Appleton and co, New York
36. Bartholow R. Medical electricity: A practical treatise on the applications of electricity to medicine and surgery. 3rd ed. (1887), Lea Brothers & Co, Philadelphia [Enlarged and improved]
37. Bartholow R. A manual of hypodermatic medication: The treatment of diseases by the hypodermatic or subcutaneous method. 5th ed. (1891), J.B. Lippincott Company, Philadelphia and London [Revised and enlarged]
38. Bartholow R. Cholera: Its causes, symptoms, pathology, and treatment (1893), Lea Brothers & Co, Philadelphia
39. Beevor C.E., and Horsley V. A record of the results obtained by electrical stimulation of the so-called motor cortex and internal capsule in an Ourang-Outang (Simia satyrus). Philosophical Transactions of the Royal Society of London, B 181 (1890) 129-158
40. Brazier M.A.B. The historical development of neurophysiology. In: Field J., Magoun H.W., and Hall V.E. (Eds). Handbook of physiology, section I: Neurophysiology: Vol. 1 (1959), American Physiological Society, Washington DC 1-58
41. Brodal P. The central nervous system (1992), Oxford University Press, New York
42. Brown-Séquard C.E. Nouvelle recherches sur le trafet des diverses espèces de conducteurs d'impressions sensitives dan la moelle épinière (troisieme partie). Archives de Physiologie Normale et Pathologique 2 (1868) 236-250
43. Butler G.F. Roberts Bartholow: A great American therapeutist. A sketch of his life and a study of his work. The American Journal of Clinical Medicine 20 (1913) 125-128 [Current name: Clinical Medicine]
44. Carville H.C., and Duret H. Gazette Médicale de Paris 2-4 January 10 (1874)
45. Carville H.C., and Duret H. Sur les fonctions des hémisphères cérébraux (histoire, critique et recherches expérimentales). Archives des Physiologie 2 (1875) 352-491 [2nd Series]
46. Cincinnati Medical News (1874). Editorial, 3. p. 385.
47. Clarke E., and Dewhurst K. An illustrated history of brain function (1972), Sandford Publications, Oxford, England
48. Clark G., and Ward J.W. Responses elicited from the cortex of monkeys by electrical stimulation through fixed electrodes. Brain 71 (1948) 332-342
49. Cobbe F.P. The moral aspects of vivisection. 4th ed. (1882), Office of the Society for Protection of Animals from Vivisection/Williams and Norgate, London and Edinburgh
50. Davis N.S. Annual address on practical medicine. Address to the members of the American Medical Association, annual meeting, June, Detroit, Michigan (1874), Detroit Free Press [Supplement, June 4]
51. In: Denny-Brown D. (Ed). Centennial anniversary volume of the American Neurological Association 1875-1975 (1975), Springer Publishing Co, New York
52. DeMyer W. Technique of the neurologic examination: A programmed text (1980), McGraw-Hill, New York
53. Detroit Free Press. The (1874a, June 2-6) minutes of the annual meeting of the American Medical Association (1874), Detroit Free Press [Supplement]
54. Detroit Free Press. The (1874b, June 2) list of delegates to the annual meeting of the American Medical Association (1874), Detroit Free Press [p. 2, column 6]
55. Dodds W.J. On the localisation of the functions of the brain. The Journal of Anatomy and Physiology 12 (1878) 340-363 454-494, 636-660
56. Dunglison R. A dictionary of medical science (1866), Henry C. Lea, Philadelphia
57. Dupuy, E. (1873). Innaugural thesis. Examen de quelques points de la physiologie du cerveau. Paris.
58. Dupuy E. On the localisation of motor centres. The London Medical Record September 15 (1876) 395-396 [Summary of paper read at meetings of the New York Neurological Association and published in New York Medical Record, July 15, 1876]
59. Dupuy E. A critical review of the prevailing theories concerning the physiology and the pathology of the brain: Localisation of function, and mode of production of symptoms. The Medical Times and Gazette (1877) [Vol. II for 1877, Part I, July 7, pp. 11-13; 32-34; July 26, pp. 84-87]
60. E.H.C. Review of R. Bartholow, a practical treatise on materia medica and therapeutics. The American Journal of the Medical Sciences 73 January (1877) 156-164 [1st ed. (1876)]
61. Ecker A. The cerebral convolutions of man, represented according to original observations, especially upon their development in the foetus, intended for the use of physicians (Robert T. Edes, Trans.) (1873), D. Appleton & Company, New York (Original German publication, 1869)
62. Fancher R. Pioneers of psychology. 3rd ed. (1996), W. W. Norton & Company, New York and London
63. Ferrier, D. (1873). Experimental researches in cerebral physiology and pathology. West Riding Lunatic Asylum Reports, London, 3, p. 30-96.
64. Ferrier D. The localization of function in the brain (Abstract). Proceedings of the Royal Society of London 22 (1873-1874) 228-232
65. Ferrier D. Bartholow's experiments on the human brain. The London Medical Record 2 (1874) 285-286 May 13
66. Ferrier D. On the localisation of the functions of the brain. The British Medical Journal 19 December (1874) 766-767
67. Ferrier, D. (1874c). Pathological illustrations of brain function. West Riding Lunatic Asylum Reports, 4, p. 30-62.
68. Ferrier, D. (1875). Experiments on the brains of monkeys.-No. I. Proceedings of the Royal Society of London, 23, 409-430; No. II. Proceedings of the Royal Society of London.
69. Ferrier D. The functions of the brain (1876), Smith, Elder & Company, London
70. Ferrier D. The localisation of cerebral disease (The Gulstonian Lectures of the Royal College of Physicians for 1878) (1878), Smith, Elder & Company, London
71. Ferrier D. The functions of the brain. 2nd ed. (1886), Smith, Elder & Company, London [Re-written and enlarged]
72. Ferrier D. The Croonian lectures on cerebral localisation (delivered before the Royal College of Physicians, June, 1890) (1890), Smith, Elder & Company, London
73. Flourens P. Recherches expérimentales sur les propriétés et les fonctions du système nerveux, dans les animaux vertébrés (1824), Crevot, Paris
74. French R.D. Antivivisection and medical science in Victorian society (1975), Princeton University Press, Princeton, New Jersey
75. Frenkel D.A. Human experimentation: Codes of ethics. Legal Medical Quarterly 1 (1977) 7-14
76. Friedlander W.J. The evolution of informed consent in American medicine. Perspectives in Biology and Medicine 38 (1995) 498-510
77. Fritsch, G., & Hitzig, E. (1870). Ueber die elektrische Erregbarkeit des Grosshirns [The electrical excitability of the cerebrum]. Archiv fur Anatomie, Physiologie und Wissenschaflichte Medezin, 37, 300-332. In R. H. Wilkins (Trans.), Neurosurgical Classic-XII. Journal of Neurosurgery, 1963, 20, 904-916.
78. Frohnmayer, K. (2001). Unethically obtained data: Publish or reject? .
79. Gaylin, W. (1989). Nazi data: Dissociation from evil: Commentary. Hasting Center Report, July/August, 19, p. 18.
80. Gosling F.G. Before Freud: Neuraesthenia and the American medical community, 1870-1910 (1987), University of Illinois Press, Urbana and Chicago
81. Hammond W.A. A treatise on diseases of the nervous system (1871), D. Appleton and Company, New York
82. Harlow J.M. Recovery from passage of an iron rod through the head. Publications of the Massachusetts Medical Society 2 (1868) 327-347
83. Henle J. Handbuch der Nervenlehre des Menschen (1871), F. Vieweg, Braunschweig
84. Hickman T.A. "Mania Americana": Narcotic addition and modernity in the United States, 1870-1920. The Journal of American History 90 (2004) 1269-1294
85. Hitzig E. Ueber die galvinischen schwindelempfindungen und eine neue Methode galvinischer reizung der Augenmuskeln [On the galvanic sensations of vertigo and a new method of galvanic irritations of the eye muscles]. Berliner Klinische Wochenschrift 11 (1870) 137-138
86. Hitzig E. Imtersuchengen über das Gehirn Abhandlungen physiologischen und pathologischen Inhalts (1874), Hirschwald, Berlin
87. Holland, J.W. (1904). Memoir of Roberts Bartholow, M.D. Transactions of the College of Physicians of Philadelphia, 3rd. Series, 26, xliii-lii (43-52).
88. Hothersall D. History of psychology. 4th ed. (2004), McGraw-Hill, New York
89. Huxley T.H. Evidence as to man's place in nature (1863), Williams & Norgate, London and Edinburgh
90. Israel Z., Hsu F.P.K., and Burchiel K.J. Is microelectrode recording necessary?. Seminars in Neurosurgery 12 (2001) 169-174
91. Jackson J.H. A study of convolutions. Transactions of the St. Andrew's Medical Graduates' Association 3 (1869) 162-204
92. Jackson, J.H. (1873). Observations on the localisation of movements in the cerebral hemispheres as revealed by cases of convulsions, chorea, and "aphasia". West Riding Lunatic Asylum Medical Reports, 3, p. 175-195.
93. Jefferson G. The prodromes to cortical localization. Journal of Neurology, Neurosurgery, & Psychiatry 16 (1953) 59-72
94. Juettner O. Daniel Drake and his followers: Historical and biographical sketches (1909), Harvey Publishing Co, Cincinnati
95. Kalechofsky, R. (2007). Human experimentation: Before the Nazi era and after. Accessed 18.04.07.
96. Keating J.M. A new pronouncing dictionary of medicine (1894), W.B. Saunders, Philadelphia
97. Keen W.W. Three successful cases of cerebral surgery. American Journal of Medical Science 96 (1888) 329-357
98. Kinealy C. A death-dealing famine: The great hunger in Ireland (1997), Pluto Press, London and Chicago
99. Kolb B., and Whishaw I.Q. Fundamentals of human neuropsychology. 4th ed. (1996), W. W. Freeman and Company, New York [5th ed., 2003]
100. Krech D. Cortical localization of function. In: Postman L. (Ed). Psychology in the making: Histories of selected research problems (1962), Alfred A. Knopf, New York 31-72
101. Kuntz A. Eduard Hitzig (1838-1907). In: Haymaker W., and Schiller F. (Eds). The founders of neurology (1970), Charles C. Thomas, Springfield, Illinois 229-233
102. Lanska D.J. Characteristics and lasting contributions of 19th-century American neurologists. Journal of the History of the Neurosciences 10 (2001) 202-216
103. Leurat, F., & Gratiolet, P. (1857) (Written by P. Gratiolet). Anatomie comparée de systeme nerveux, consideré dans a ses rapports avec l'intelligence. Paris: J.B. Ballière et Fils, Vol. 2.
104. Leyden E. Beitrage und Untersuchunfen zur Physiologie und Pathologie des Gehirns. 1. Ueber Hirndruck und Hirnbewegungen. Virchow's Archiv für pathologische Anatomie und Physiologie und für klinische Medizin 37 (1866) 519-559
105. Lombard J.S. Experimental researches on the regional temperature of the head under conditions of rest, intellectual activity, & emotion (1879), H.K. London, London
106. Longet F.-A. Anatomie et physiologie du système nerveux de l'homme et des animaux vertébrés (1842), Fortin, Masson et Cie, Paris
107. Luys, J.B. (1865). Recherches sur le système nerveux cérébro-spinal, sa structure, ses fonctons et ses maladies. Accompagné d'un atlas de 40 planches. Paris: J.-B. Ballière et fils. New York: Ballière Brothers.
108. Macmillan M. An odd kind of fame: Stories of Phineas Gage (2000), The M.I.T. Press, Cambridge, Mass
109. Magendie F. Leçons sur les fonctions et les maladies du système nerveux (1839), Ebrard, Paris
110. Meynert, T. (1867-1868). Der Bauder gross-hirnrinde und seine örtlichen Verschiedenheiten, nebst einem pathologisch-anatomischen. Corollarium. Vierteljahrsschrift für Psychiatrie. Neuwied and Leipzig, 1867, 1, 77-93; 198-217; 1868, 2, 88-113.
111. Mills C.K. Cerebral localisation in its practical relations. Brain 12 (1888-1889) 233-288 358-406
112. Nauta W.J.H., and Feirtag M. Fundamental neuroanatomy (1986), W.W. Freeman and Co, New York
113. Neuburger M. The historical development of experimental brain and spinal cord physiology before Flourens. [Trans. and edited, with additional material by E. Clarke] (1981), The Johns Hopkins University Press, Baltimore [Orig. published as Die Historische Entwicklung der Experimentellen Gehirn- und Rückenmarksphysiologie vor Flourens, Stuttgart: Ferdinand Enke Verlag, 1897]
114. Niehoff D. The biology of violence. How understanding the brain, behavior, and environment can break the vicious circle of aggression (1999), The Free Press. http://print.google.com/print/doc?isbn=068431325 Excerpt. Accessed 22.07.04
115. Nothnagel H. Untersuchungen ueber die Functionen des Gehirns. Virchow's Archiv für pathologische Anatomie und Physiologie und für klinische Medizin 57 (1873) 184-214
116. Nyberg-Hansen R., and Brodal A. Sites of termination of corticospinal fibers in the cat. An experimental study with silver impregnation methods. Journal of Comparative Neurology 120 (1963) 369-391
117. Ojemann G.A., and Whitaker H.A. Language localization and variability. Brain and Language 6 (1978) 239-260
118. Owen R. On the characters, principles of division, and primary groups of the class mammalia. Journal of the Linnaean Society 2 (1857) 1-37
119. Owen R. On the anatomy of vertebrates. On the anatomy of vertebrates Vol. III (1868), Longmans, Green and Co, London
120. Oxford English Dictionary. The compact edition of 1971 (1971), Oxford University Press, Oxford [2 volumes]
121. Ozer M.N. The British vivisection controversy. Bulletin of the History of Medicine 60 (1966) 158-167
122. Pagenstecher F. Experimente und Studien über Gehirndruck (1871), C. Winters Universitätsbuchhandlung, Heidelberg
123. Palmer B.W. Medical classics: Favorite prescriptions of distinguished practitioners: With notes on treatment compiled from the published writings or unpublished sources of Drs. Fordyce Barker, Roberts Bartholow [etc.] (1888), E.B. Treat, New York
124. Parsons G.P. Equal treatment for all: American medical remedies for male sexual problems: 1850-1900. Journal of the History of Medicine and Allied Sciences 32 1 (1977) 55-71
125. Penfield W., and Boldrey E. Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical stimulation. Brain 60 (1937) 389-443
126. R.T.E. Review of R. Bartholow, a practical treatise on materia medica and therapeutics. The American Journal of the Medical Sciences 87 January (1884) 234-235 [5th ed. (1883)]
127. Roth J.A., Greenfield A.J., Kaihara S., and Wagner Jr. H.N. Total and regional cerebral blood flow in unanesthetized dogs. American Journal of Physiology 219 (1970) 96-101
128. Russell J.R., and DeMyer W. The quantitative cortical origin of pyramidal axons of Macaca rhesus. Neurology 11 (1961) 96-108
129. S.A. Review of R. Bartholow, spermatorrhoea: Its causes, symptoms, results, and treatment. The American Journal of the Medical Sciences 79 January (1880) 240-241 [4th ed., revised]
130. Scarff J.E. Primary cortical centers for movements of upper and lower limbs in man. Archives of Neurology and Psychiatry 44 (1940) 243-299
131. Sciamanna E. Gli avversari delle localizzationi cerebrali. Archivio di psichiatria, scienze penali ed antropologia criminale 3 (1882) 208-215
132. Sciamanna, E. (1882b). Fenomeni prodotti dall' applicazione della corrente elettrica sulla dura madre e modificazione del polso cerebrale. Atti della Accademia nazionale dei Lincei. Rendiconti. Classe di Scienze fisiche matematiche et naturale, Roma, 13, 25-42.
133. Thomas R.K., and Young C.D. A note on the early history of electrical stimulation of the human brain. The Journal of General Psychology 120 (1993) 73-81
134. In: Todd R.B. (Ed). Cyclopedia of anatomy and physiology IV (1847-1849), Longman, Brown, Green, Longmans and Roberts, London
135. Turner W. The convolutions of the human cerebrum topographically considered (1866), Maclachlan & Stewart, Edinburgh
136. Uematsu S., Lesser R., Fisher R.S., Gordon B., Hara K., Krauss G.L., et al. Motor and sensory cortex in humans: Topography studied with chronic subdural stimulation. Neurosurgery 31 1 (1992) 59-71
137. Union list of serials in libraries of the United States and Canada (1965). In E. B. Titus (Ed.), (3rd ed. Vol. 1) New York: The H.W. Wilson Co.
138. Valenstein E. Brain control: A critical examination of brain stimulation and psychosurgery (1973), John Wiley & Sons, New York
139. Vulpian A. Leçons sur la physiologie générale et comparée du système nerveux: Fair au Muséum d'Histoire Naturelle (1866), G. Ballière, Paris
140. Warner J.H. Ideals of science and their discontents in late nineteenth-century American medicine. ISIS 82 (1991) 454-478
141. Welker W.I., Benjamin R.M., Milles R.C., and Woolsey C.N. Motor effects of stimulation of cerebral cortex of squirrel monkey (Saimiri sciureus). Journal of Neurophysiology 20 (1957) 347-364
142. Zimmerman, J., & Jacobson, S. (1989). Anatomy. Illustrated primarily by Ronald A. Brandon. Boston: Little, Brown and Company.