Intracerebral diffusion of new cholesterol-based anticancer conjugate in tumor-bearing rat model

Journal of Applied Research

Volumn 4, Issue 1, 2004, Pages 127-134

  Alanazi, Fars ^a   Halpern, David S ^b   Lu, D Robert ^c  

^a UNIVERSITY OF GEORGIA   (United States)

^b Isotron Inc   (United States)

^c TEMPLE UNIVERSITY   (United States)

Author keywords

Brain tumor; Cholesterol esterase; Cholesteryl conjugate; Lipoprotein lipase; Liposome; Tissue drug diffusion

Indexed keywords

ANTINEOPLASTIC AGENT; BORON DERIVATIVE; CHOLESTEROL DERIVATIVE; CHOLESTEROL ESTERASE; CHOLESTEROL OLEATE; CHOLESTERYL 1,12 DICARBA CLOSO DODECABORANE 1 CARBOXYLATE; LIPOPROTEIN LIPASE; LIPOSOME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONJUGATE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG DIFFUSION; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; DRUG TUMOR LEVEL; GLIOMA CELL; HYDROPHOBICITY; MALE; NONHUMAN; RAT; TUMOR MODEL;

EID: 6444228167     PISSN: 1537064X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Anderson RN. Deaths: leading causes for 2000. Natl Vital Stat Rep. 2002;50:1-85.
2. Zee-Cheng RK, Cheng CC. Delivery of anticancer drugs. Methods Find Exp Clin Pharmacol 1989;11:439-529.
3. Lu DR, Mehta SC, Chen W. Selective boron drug delivery to brain tumors for boron neutron capture therapy. Adv Drug Deliv Rev. 1997;26:231-247.
4. Peacock G, Ji B, Wang CK, Lu DR. Cell cultural studies for a carborane cholesteryl ester with conventional and PEG liposomes. Drug Delivery. 2003;10:29-34.
5. Peacock G, Sidwell R, Pan G, Oie S, Lu DR. In vitro uptake of a new cholesteryl carborane ester compound in human glioma cell lines. J Pharm Sci. 2004;93:13-19.
6. Ji B, Peacock G, Lu DR. Synthesis of cholesterol-carborane conjugate for targeted drug delivery. Bioorganic Med Chem Lett. 2002;12:2455-2458.
7. Alanazi F, Li H, Halpern DS, Øie S, Lu DR. Synthesis, preformulation and liposomal formulation of cholesteryl carborane esters with various fatty chains. Int J Pharm. 2003;225:189-197.
8. Ji B, Chen W, Lu DR, Halpern DS. Cell culture and animal studies for intracerebral delivery of borocaptate in liposomal formulation. Drug Deliv. 2001;8:13-17.
9. Sidwell R. Extraction and analysis by HPLC of the novel compound BCH in formulations, cell culture, and animal tissues [thesis]. Athens, Ga: University of Georgia; 2002.
10. Callahan DE, Forte TM, Afzal SM, et al. Boronated protoporphyrin (BOPP): localization in lysosomes of the human glioma cell line SF-767 with uptake modulated by lipoprotein levels. Int J Radial Oncol Biol Phys. 1999;45:761-771.
11. Murakami M, Ushio Y, Mihara Y et al. Cholesterol uptake by human glioma-cell via receptor-mediated endocytosis of Low-density lipoprotein. J Neurosurg. 1990;73:760-767.
12. Rudling MJ, Angelin B, Peterson CO, Collins VP. Low-density lipoprotein receptor activity in human intracranial tumors and its relation to the cholesterol requirement. Cancer Res. 1990;50:483-487.
13. Lombardi P, Norata G, Maggi FM et al. Assimilation of LDL by experimental-tumors in mice. Biochim Biophys Acta. 1989;1003:301-306.
14. Maletinska L, Blakely EA, Bjornstad KA, et al. Human glioblastoma cell lines: Levels of low-density lipoprotein receptor and low-density lipoprotein receptor-related protein. Cancer Res. 2000;60:2300-2303.
15. Pan G. In vitro gene and drug delivery and targeting to human glioma cells by lipoprotein mimics [thesis]. Athens, Ga: University of Georgia; 2003.
16. McKeran RO, Firth G, Oliver S, Uttley D, O'Laoire S. A potential application for the intracerebral injection of drugs entrapped within liposomes in the treatment of human cerebral gliomas. J Neurol Neurosurg Psychiatry. 1985;48:1213-1219.
17. Firth G, Oliver AS, McKeran RO. Studies on the intracerebral injection of bleomycin free and entrapped within liposomes in the rat. J Neurol Neurosurg Psychiatry. 1984;47:585-589.
18. Oliver AS, Firth G, McKeran RO. Studies on the intracerebral injection of vincristine free and entrapped within liposomes in the rat. J Neurol Sci. 1985;68:25-30.
19. Johnson RC, Shah SM. Cholesterol ester metabolizing enzymes in human brain: properties, subcellular distribution and relative levels in various diseases conditions. J Neurochem. 1978;31:895-902.
20. Nunez M, Peinado-Onsurbe J, Vilaro S, Llobera M. Lipoprotein lipase activity in Developing Rat brain areas. Biol Neonate. 1995;68:119-127.
21. Ogino T, Suzuki K. Specificities of human and rat brain enzymes of cholesterol ester metabolism toward very long chain acids: implication for biochemical pathogenesis of Adrenoleukodystrophy. J Neurochem. 1981;36:776-779.
22. Roussea A, Dubois G, Gatt S. Subcelluar distribution of diacylglycerol lipase in rat and mouse brain. Neurochem Res. 1983;8:417-422.
23. Brecher P, Chobanian J, Small DM, Chobanian AV. The use of phospholipid vesicles for in vitro studies on cholesteryl ester hydrolysis. J Lipid Res. 1976;17:239-247.
24. Ishii I, Onozaki R, Takahashi E, et al. Regulation of neutral cholesterol esterase activity by phospholipids containing negative charges in substrate liposome. J Lipid Res. 1995;36:2303-2310.
25. VanDort M, Schwendner SW, Skinner RW, Gross MD, Counsell RE. Potential tumor or organ-imaging agents. 24. Radioidinated pregenolone esters. Steroid. 1984;44:85-93.
26. Morrison RT, Body RN. Organic chemistry. 3rd ed. Boston, Mass: Allan and Bacon Inc; 1973:603.