Cholesterol lowering effect of sulfur-containing amino acids added to a soybean protein diet in rats

Journal of Nutritional Science and Vitaminology

Volumn 54, Issue 6, 2008, Pages 448-453

  Taniguchi, Misako ^a   Nagao, Koji ^b   Inoue, Keiko ^a   Imaizumi, Katsumi ^c  

^a NAKAMURA GAKUEN UNIVERSITY   (Japan)

^b SAGA UNIVERSITY   (Japan)

^c KYUSHU UNIVERSITY   (Japan)

Author keywords

Cholesterol 7 hydroxylase; Glutathione; HMG CoA reductase; Soybean protein isolate; Sulfur containing amino acids

Indexed keywords

BILE ACID; CASEIN; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CYSTINE; GLUTATHIONE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; METHIONINE; SOYBEAN PROTEIN; SULFUR AMINO ACID; 3 HYDROXY 3 METHYLGLUTARYL COENZYME A; 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A; ACYL COENZYME A; CYSTEINE; HYPOCHOLESTEROLEMIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; FECES ANALYSIS; FOOD INTAKE; LIVER LEVEL; LIVER WEIGHT; MALE; NONHUMAN; PROTEIN DIET; PROTEIN INTAKE; RAT; STEROID EXCRETION; WEIGHT GAIN; ANIMAL; BODY WEIGHT; CALORIC INTAKE; CHEMISTRY; DRUG EFFECT; FECES; LIVER; METABOLISM; SOYBEAN; WISTAR RAT;

GLYCINE MAX; RATTUS;

ACYL COENZYME A; ANIMALS; ANTICHOLESTEREMIC AGENTS; BODY WEIGHT; CASEINS; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; CYSTEINE; DIETARY SUPPLEMENTS; ENERGY INTAKE; FECES; GLUTATHIONE; LIVER; MALE; METHIONINE; RATS; RATS, WISTAR; SOYBEAN PROTEINS; SOYBEANS;

EID: 64349107010     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.54.448     Document Type: Article

References (34)

1. Carroll KK, Kurowska EM. 1995. Soy consumption and cholesterol reduction: review of animal and human studies. J Nutr 125: 594S-597S.
2. Anderson JW, Johnstone BM, Cook-Newell ME. 1995. Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 333: 276-282.
3. Nagata Y, Imaizumi K, Sugano M. 1980. Effects of soyabean protein and casein on serum cholesterol levels in rats. Br J Nutr 44: 113-121.
4. Nagata Y, Ishiwaki N, Sugano M. 1982. Studies on the mechanism of antihypercholesterolemic action of soy protein and soy protein-type amino acid mixtures in relation to the casein counterparts in rats. J Nutr 112: 1614-1625.
5. Choi YS, Goto S, Ikeda I, Sugano M. 1989. Interaction of dietary protein, cholesterol and age on lipid metabolism of the rat. Br J Nutr 61: 531-543.
6. Madani S, Lopez S, Blond JP, Prost J, Belleville J. 1998. Highly purified soybean protein is not hypocholesterolemic in rats but stimulates cholesterol synthesis and excretion and reduces polyunsaturated fatty acid biosynthesis. J Nutr 128: 1084-1091.
7. Ni W, Yoshida S, Tsuda Y, Nagao K, Sato M, Imaizumi K. 1999. Ethanol-extracted soy protein isolate results in elevation of serum cholesterol in exogenously hypercholesterolemic rats. Lipids 34: 713-716.
8. Anthony MS, Clarkson TB, Hughes CL Jr, Morgan TM, Burke GL. 1996. Soybean isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys. J Nutr 126: 43-50.
9. Greaves KA, Wilson MD, Rudel LL, Williams JK, Wagner JD. 2000. Consumption of soy protein reduces cholesterol absorption compared to casein protein alone or supplemented with an isoflavone extract or conjugated equine estrogen in ovariectomized cynomolgus monkeys. J Nutr 130: 820-826.
10. Lichtenstein AH. 1998. Soy protein, isoflavones and cardiovascular disease risk. J Nutr 128: 1589-1592.
11. Anderson JJ, Anthony MS, Cline JM, Washburn SA, Garner SC. 1999. Health potential of soy isoflavones for menopausal women. Public Health Nutr 2: 489-504.
12. Sugiyama K, Ohkawa S, Muramatsu K. 1986. Relationship between amino acid composition of diet and plasma cholesterol level in growing rats fed a high cholesterol diet. J Nutr Sci Vitaminol 32: 413-423.
13. Morita T, Oh-hashi A, Takei K, Ikai M, Kasaoka S, Kiriyama S. 1997. Cholesterol-lowering effects of soybean, potato and rice proteins depend on their low methionine contents in rats fed a cholesterol-free purified diet. J Nutr 127: 470-477.
14. Sugiyama K, Yamakawa A, Kumazawa A, Saem S. 1997. Methionine content of dietary proteins affects the molecular species composition of plasma phosphatidylcholine in rats fed a cholesterol-free diet. J Nutr 127: 600-607.
15. Potter SM, Kies CV. 1990. Influence of sulfur-amino acid content variation in plant vs animal protein on serum and tissue lipids in rats. Plant Foods Hum Nutr 40: 297-308.
16. Aoyama Y, Amano N, Yoshida A. 1999. Cholesterol synthesis and degradation in normal rats feda cholesterol-free diet with excess cystine. Lipids 34: 583-589.
17. Taniguchi M, Inoue M. 1986. Ontogenic changes in metabolism and transport of glutathione in the rat. J Biochem 100: 1457-1463.
18. Roitelman J, Shechter I. 1984. Regulation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase. Evidence for thiol-dependent allosteric modutation of enzyme activity. J Biol Chem 259: 870-877.
19. Roitelman J, Shechter I. 1986. Altered kinetic properties of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase following dietary manipulations. J Biol Chem 261: 5061-5066.
20. Tasker TE, Potter SM. 1993. Effects of dietary protein source on plasma lipids, HMG CoA reductase activity, and hepatic glutathione levels in gerbils. J Nutr Biochem 4: 458-462.
21. Hassan AS. 1988. Effects of chronic inhibition of glutathione biosynthesis on cholesterol and bile acid metabolism in rats. Biochim Biophys Acta 963: 131-138.
22. Hassan AS, Bunick D, St Denis SH, Lund LA. 1993. Glutathione and bile acid synthesis. II. Effect of hepatic glutathione content on the activity and mRNA levels of cholesterol 7 alpha-hydroxylase in the rat. Biochem Pharmacol 46: 555-556.
23. Reeves PG, Nielsen FH, Fahey GC Jr. 1993. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr 123: 1939-1951.
24. Taniguchi M, Yasutake A, Takedomi K. 2000. Effects of dietary sulfur-containing amino acids on oxidative damage in rat liver caused by N-nitrosodimethylamine administration. Br J Nutr 84: 211-217.
25. Folch J, Lee M, Sloane-Stanley GH. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509.
26. Fletcher MJ. 1968. A colorimetric method for estimating serum triglyceride. Clin Chim Acta 22: 393-397.
27. Nagao K, Sakono M, Sakurai H, Sato M, Imaizumi K. 1997. Exogenously hypercholesterolemic rats, compared with their progenitor Sprague-Dawley rats, have altered mRNAs for cholesterol 7alpha-hydroxylase and low-density lipoprotein receptor and activities of cholesterol 7alpha-hydroxylase and acyl-CoA:cholesterol acyltransferase in the liver in response to dietary cholesterol. Comp Biochem Physiol 118B: 949-955.
28. Ide T, Okamatsu H, Sugano M. 1978. Regulation by dietary fats of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in rat liver. J Nutr 108: 601-612.
29. Cantfort IV, Renson J, Gielen J. 1975. Rat liver cholesterol 7α-hydroxylase. Eur J Biochem 55: 23-31.
30. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ. 1951. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275.
31. Reed DJ, Babson JR, Beatty PW, Brodie AE, Ellis WW, Potter DW. 1980. High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides. Anal Biochem 106: 55-62.
32. el Yaagoubi M, Visvikis A, Siest G, Wellman M. 1995. Developmental- and tissue-specific DNA methylation patterns and expression of rat gamma-glutamyltransferase. Biochem Mol Biol Int 36: 257-264.
33. Hiroi Y, Oka T, Taniguchi M. 1997. Changes of γ-glutamyltransferase gene expression of livers in weanling rats fed a low soybean protein isolate diet. J Jpn Soc Nutr Food Sci 50: 261-265.
34. Kurowska EM, Carroll KK. 1994. Hypercholesterolemic response in rabbits to selected groups of dietary essential amino acids. J Nutr 124: 364-370.