Genetic Polymorphisms in CYP3A5 and MDR1 Genes and Their Correlations With Plasma Levels of Tacrolimus and Cyclosporine in Renal Transplant Recipients

Transplantation Proceedings

Volumn 41, Issue 3, 2009, Pages 840-842

  Mendes, J ^a   Martinho, A ^a   Simoes, O ^a   Mota, A ^b   Breitenfeld, L ^c   Pais, L ^a  

^a Centro de Histocompatibilidade do Centro Coimbra   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF BEIRA INTERIOR   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN; CYTOCHROME P450 3A5; MULTIDRUG RESISTANCE PROTEIN 1; TACROLIMUS;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; FEMALE; GENETIC ANALYSIS; GENOTYPE; GRAFT SURVIVAL; HETEROZYGOSITY; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT; KIDNEY TRANSPLANTATION; MALE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADENINE; CYCLOSPORINE; CYTOCHROME P-450 CYP3A; DNA PRIMERS; FEMALE; GUANINE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; MALE; P-GLYCOPROTEIN; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; TACROLIMUS; THYMINE;

EID: 64349100838     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2009.01.050     Document Type: Article

References (5)

1. Masuda S., and Inuia K. An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients. Pharmacol Ther 112 (2006) 184
2. Hoffmeyer S., Burk O., von Richter O., et al. Functional polymorphisms of the human multidrugresistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc Natl Acad Sci U S A 97 (2000) 3473
3. Wei-lin W., Jin J., Shu-sen Z., et al. Tacrolimus dose requirement in relation to donor and recipient ABCB1 and CYP3A5 gene polymorphisms in Chinese liver transplant patients. Liver Transpl 12 (2006) 775
4. Kuehll P., Zhang J., Lin Y., et al. Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression. Nat Genet 27 (2001) 383
5. Anglicheau D., Verstuyft C., Laurent-Puig P., et al. Association of the Multidrug Resistance-1 gene single nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients. J Am Soc Nephrol 14 (2003) 189