Synthesis and anti-hepatitis B virus activities of Matijing-Su derivatives

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 8, 2009, Pages 3118-3125

  Xu, Bixue ^a   Huang, Zhengming ^b   Liu, Changxiao ^c   Cai, Zegui ^a   Pan, Weidong ^a   Cao, Peixue ^a   Hao, Xiaojiang ^a   Liang, Guangyi ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b BEIJING 302 HOSPITAL   (China)

^c TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

Anti hepatitis B virus activity; Derivatives of Matijing Su; Synthesis

Indexed keywords

ANTIVIRUS AGENT; LAMIVUDINE; N (N 3'' CHLORO BENZOYLPHENYLALANYL)PHENYLALANINE METHYL ESTER; N (N 3'' CHLORO BENZOYLPHENYLALANYL)PHENYLALANOL; N (N 3'' CHLORO BENZOYLPHENYLALANYL)TYROSINE METHYL ESTER; N (N 4'' METHYLBENZOYLPHENYLALANYL)PHENYLALANINE METHYL ESTER; N (N 4'' METHYLBENZOYLPHENYLALANYL)PHENYLALANOL; N (N 5'' CHLORO BENZOYLPHENYLALANYL)PHENYLALANOL; N (N 5'' FLUORO BENZOYLPHENYLALANYL)PHENYLALANINE METHYL ESTER; N (N 5'' METHYLBENZOYL 7 ACETAMIDO PHENYLALANYL) O ACETYLTYROSINE METHYL ESTER; N (N 5'' METHYLBENZOYL 7 NITRO PHENYLALANYL)TYROSINE METHYL ESTER; N (N 5'' METHYLBENZOYLPHENYLALANYL)PHENYLALANOL; N (N 5'' METHYLBENZOYLPHENYLALANYL)TYROSINE METHYL ESTER; N (N BENZOYL 7 ACETAMIDO PHENYLALANYL)PHENYLALANINE METHYL ESTER; N (N BENZOYL 7 ACETAMIDO PHENYLALANYL)PHENYLALANOL; N (N BENZOYL 7 NITRO PHENYLALANYL)PHENYLALANINE; N (N BENZOYL 7 NITRO PHENYLALANYL)PHENYLALANINE METHYL ESTER; N (N BENZOYL 7 NITRO PHENYLALANYL)TYROSINE METHYL ESTER; N (N BENZOYL PHENYLALANYL) O ACETYL PHENYLALANOL; N (N BENZOYLPHENYLALANYL) 7' ACETAMIDO PHENYLALANINE; N (N BENZOYLPHENYLALANYL) 7' ACETAMIDO PHENYLALANINE METHYL ESTER; N (N BENZOYLPHENYLALANYL) 7' ACETAMIDO PHENYLALANOL; N (N BENZOYLPHENYLALANYL) 7' PROPIONAMIDO PHENYLALANINE; N (N BENZOYLPHENYLALANYL) 7'' NITRO PHENYLALANINE METHYL ESTER; N (N BENZOYLPHENYLALANYL) 7'' NITRO PHENYLALANOL; N (N BENZOYLPHENYLALANYL)PHENYLALANINE; N (N BENZOYLPHENYLALANYL)PHENYLALANINE METHYL ESTER; N (N BENZOYLPHENYLALANYL)PHENYLALANOL; N (N BENZOYLPHENYLALANYL)TYROSINE; N (N BENZOYLPHENYLALANYL)TYROSINE METHYL ESTER; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CELL LINE; HEPATITIS B VIRUS; HUMANS; INHIBITORY CONCENTRATION 50; LAMIVUDINE; MOLECULAR STRUCTURE; PHENYLALANINE; STRUCTURE-ACTIVITY RELATIONSHIP;

HEPATITIS B VIRUS;

EID: 64349097834     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.03.003     Document Type: Article

References (18)

1. Lai C.L., Ratziu V., Yuen M.F., and Poynard T. Lancet 362 (2003) 2089
2. Kelleher T.B., and Afdhal N. J. Hepatol. 44 (2006) S126
3. Sprengers D., van Gelder T., Zondervan P.E., Niesters H.G., Janssen H.L., and de Man R.A. Ned. Tijdschr. Geneeskd. 146 (2002) 1380
4. Cha M.Y., Kim C.M., Park Y.M., and Ryu W.S. Hepatology 39 (2004) 1683
5. Koike K. Intervirology 38 (1995) 134
6. Tang H., Oishi N., Kaneko S., and Murakami S. Cancer Sci. 97 (2006) 977
7. Lai C.L., Chien R.N., Leung N.W., Chang T.T., Guan R., Tai D.I., Ng K.Y., Wu P.C., Dent J.C., Barber J., Stephenson S.L., and Gray D.F. N. Engl. J. Med. 339 (1998) 61
8. Dienstag J.L., Schiff E.R., Wright T.L., Perrillo R.P., Hann H.W., Goodman Z., Crowther L., Condreay L.D., Woessner M., Rubin M., and Brown N.A. N. Engl. J. Med. 341 (1999) 1256
9. Hadziyannis S.J., Tassopoulos N.C., Heathcote E.J., Chang T.T., Kitis G., Rizzetto M., Marcellin P., Lim S.G., Goodman Z., Wulfsohn M.S., Xiong S., Fry J., and Brosgart C.L. N. Engl. J. Med. 348 (2003) 800
10. Marcellin P., Chang T.T., Lim S.G., Tong M.J., Sievert W., Shiffman M.L., Jeffers L., Goodman Z., Wulfsohn M.S., Xiong S., Fry J., and Brosgart C.L. N. Engl. J. Med. 348 (2003) 808
11. Liaw Y.F. Antiviral Chem. Chemother. 12 (2001) 67
12. Lai C.L., Dienstag J., Schiff E., Leung N.W., ATkins M., Hunt C., Brown N., Woessner M., Boehme R., and Condreay L. Clin. Infect. Dis. 6 (2003) 687
13. Hadziyannis S.J., Tassopoulos N.C., Heatchcote E.J., Chang T.T., Kitis G., Rizzetto M., Marcellin P., Lim S.G., Goodman Z., Ma J., Arterburn S., Xiong S., Currie G., and Brosgart C.L. N. Engl. J. Med. 352 (2005) 2673
14. Wong D.K., Cheung A.M., O'Rourke K., Naylor C.D., Detsky A.S., and Heathcote J. Ann. Int. Med. 119 (1993) 312
15. Lok A., and McMahon B. Hepatology 34 (2004) 1225
16. Liang, G.Y.; Liu, Y.M.; Xu, B.X. CN Patent 02160309.X, 2002.
17. Katz B.M., Lundquist L.J., Walsh D.A., and Glass D.B. Int. J. Pept. Protein Res. 33 (1989) 439
18. Zou C., Zhang R.P., Zhao B.T., Ao X., Hao X.J., and Zhou J. Acta Botanica Yunnanica 21 (1999) 121