Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity

European Journal of Medicinal Chemistry

Volumn 44, Issue 6, 2009, Pages 2689-2695

  Magoulas, George ^a   Papaioannou, Dionysios ^a   Papadimou, Evangelia ^b   Drainas, Denis ^b  

^a UNIVERSITY OF PATRAS   (Greece)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

Acitretin; All trans retinoic acid; Polyamines; Retinoids; Ribonuclease P inhibition; Spermine conjugates

Indexed keywords

N 1 (RETINOYL)SPERMINE; N 1 ACITRETINYLSPERMINE; N 1,N 12 BIS(RETINOYL)SPERMINE; N 1,N 12 BISACITRETINYLSPERMINE; N 4,N 9 BIS(RETINOYL) N 1,N 12 BISTRIFLUOROACETYLSPERMINE; N 4,N 9 BIS(RETINOYL)SPERMINE; RETINOID DERIVATIVE; RIBONUCLEASE P; SPERMINE DERIVATIVE; SUCCINIMIDYL ACITRETINATE; SUCCINIMIDYL RETINOATE; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CONTROLLED STUDY; DEPROTECTION REACTION; DICTYOSTELIUM DISCOIDEUM; DRUG CONJUGATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; DICTYOSTELIUM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; MOLECULAR STRUCTURE; RIBONUCLEASE P; SPERMINE; STEREOISOMERISM; TRETINOIN;

EID: 64249152762     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.01.001     Document Type: Article

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