Fritless chromatographic microfluidic-based columns for chemical separations

American Laboratory

Volumn 40, Issue 18, 2008, Pages 13-16

  Gaspar, Attila ^a   Baghdachi, Shima ^b   Goldberg, Mark ^b   Stevens, Schetema ^b   Torres, Jaime ^b   Salgado, Marisol ^b   Gomez, Frank A ^b  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL SEPARATIONS; CHROMATOGRAPHIC PACKINGS; MICRO-FLUIDIC; MICRO-FLUIDIC CHANNELS; POLY(DIMETHYLSILOXANE) CHIPS; PROTEIN PURIFICATIONS; RESIDUAL WATERS; REVERSED-PHASE; STATIONARY PHASE;

CHROMATOGRAPHIC ANALYSIS; INTEGRATED CIRCUITS; LIQUID CHROMATOGRAPHY; METHANOL; SILICONES;

SUSPENSIONS (FLUIDS);

EID: 64249147346     PISSN: 00447749     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Article

References (16)

1. Tabeling, P. Introduction to Microfluidics; Oxford University Press: Oxford, U.K.; 2005.
2. Ehlert, S.; Tallarek, U. High-pressure liquid chromatography in lab-on-a-chip devices. Anal. Bioanal. Chem. 2007, 388, 517-20.
3. Ying, H.; Killeen, K.; Brennan, R.; Sobek, D.; Werlich, M.; Van de Goor, T. Microfluidic chip for peptide analysis with an integrated HPLC column sample enrichment column, and nanoelectrospray tip. Anal. Chem. 2005, 77, 527-371
4. Pamme, N. Continuous flow separations in microfluidic devices. Lab Chip 2007, 7, 1644-59.
5. Ghitun, M.; Bonneil, E.; Fortier, M.-H.; Yi, H.; Killeen, K.; Thibault, P. Integrated microfluidic devices with enhanced separation performance: application to phosphopro-teome analyses of differentiated cell model systems. J. Sep. Sci. 2006, 29, 1539-49.
6. Foote, R.S.; Khandurina, J.; Jacobson, S.C.; Ramsey, J.M. Preconcentration of proteins on microfluidic devices using porous silica membranes. Anal. Chem. 2005, 77, 57-63.
7. Koesdjojo, M.T.; Tennico, Y.H.; Remcho, V.T. Fabrication of a microfluidic system for capillary electrophoresis using a two-stage embossing technique and solvent wetting on poly(methyl methacrylate) with water as a sacrificial layer. Anal. Chem. 2008, 80, 2311-18.
8. Li, S.F.Y.; Kricka, L.J. Clinical analysis by microchip capillary electrophoresis. Clin. Chem. 2006, 52, 37-45.
9. Liu, D.; Shi, M.; Huang, H.; Long, Z.; Zhou, X.; Qin, J.; Lin, B. Isotachopho-resis preconcentration integrated microfluidic chip for highly sensitive genotyping of the hepatitis B virus. J. Chromatogr. B 2006, 844, 32-8.
10. Bandilla, D.; Skinner, CD. Capillary electrochromatography of peptides and proteins, J. Chromatogr. B 2004, 1044, 113-29.
11. Gaspar, A.; Piyasena, M.E.; Gomez, F.A. Simple fabrication of fritless chromatographic microchips packed with conventional reversed-phase silica particles. Anal. Chem. 2007, 79, 7906-9.
12. Duffy, D.C.; McDonald, J.C.; Schuel-ler, O.J.A.; Whitesides, G.M. Rapid prototyping of microfluidic systems in poly(dimethylsiloxane). Anal. Chem. 1998, 70, 4974-84.
13. Gaspar, A.; Piyasena, M.; Daroczi, L.; Gomez, F.A. Magnetically controlled valve for flow manipulation in polymer microfluidic devices. Micro. Nano. 2008, in press.
14. Lotters, J.C.; Olthuis, W.; Veltink, P.H.; Bergveld, P. The mechanical properties of the rubber elastic polymer polydimethylsiloxane for sensor applications. J. Micromech. Microeng. 1997, 7, 145-7.
15. He, B.; Tait, N.; Regnier, F. Fabrication of nanocolumns for liquid chromatography. Anal. Chem. 1998, 70, 3790-7.
16. Knox, J.H.; Parcher, J.F. Effect of column to particle diameter ratio on the dispersion of unsorbed solutes in chromatography. Anal. Chem. 1969, 41, 1599-1606.