Synthesis and stereochemical preference of peptide 4-aminocyclophosphamide conjugates as potential prodrugs of phosphoramide mustard for activation by prostate-specific antigen (PSA)

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 9, 2009, Pages 2587-2590

  Jiang, Yongying ^a   DiPaola, Robert S ^b   Hu, Longqin ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Cyclophosphamide; Prodrug; Prostate specific antigen; Proteolytic

Indexed keywords

CYCLOPHOSPHAMIDE DERIVATIVE; PHOSPHORAMIDE MUSTARD; PROSTATE SPECIFIC ANTIGEN; TETRAPEPTIDE;

ARTICLE; CIS ISOMER; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DEGRADATION; DRUG HALF LIFE; DRUG SYNTHESIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEIN DEGRADATION; STEREOCHEMISTRY;

CHROMATOGRAPHY, LIQUID; CYCLOPHOSPHAMIDE; DRUG DESIGN; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; MODELS, CHEMICAL; PEPTIDES; PRODRUGS; PROSTATE-SPECIFIC ANTIGEN; PROSTATIC NEOPLASMS; PROTEIN ISOFORMS; STEREOISOMERISM; TIME FACTORS;

EID: 64249126309     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.009     Document Type: Article

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