N-(2,2-Dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide as a potential bioreductively activated prodrug of phosphoramide mustard

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 14, 2008, Pages 4059-4063

  Jiang, Yongying ^a   Hu, Longqin ^a,b  

^a RUTGERS UNIVERSITY   (United States)

^b RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

Bioreductive activation; Cyclization; Cyclophosphamide; Phosphoramide mustard; Prodrug

Indexed keywords

4 AMINOCYCLOPHOSPHAMIDE; ACID; AMINE; AMINO ACID; CYCLOPHOSPHAMIDE DERIVATIVE; DRUG METABOLITE; HYDRONIUM ION; N [2,2 DIMETHYL 2 (2 NITROPHENYL)ACETYL] 4 AMINOCYCLOPHOSPHAMIDE; PHOSPHORAMIDE MUSTARD; PRODRUG;

ARTICLE; BIOREDUCTIVE ACTIVATION; CANCER THERAPY; CATALYSIS; CHEMICAL REACTION; CYCLIZATION; CYTOTOXICITY; DEGRADATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELIMINATION REACTION; ISOMER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; PH; REDUCTION; STEREOSPECIFICITY; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTINEOPLASTIC AGENTS, ALKYLATING; CATALYSIS; CHROMATOGRAPHY, LIQUID; CYCLOPHOSPHAMIDE; DRUG DESIGN; HYDROGEN-ION CONCENTRATION; IONS; KINETICS; MASS SPECTROMETRY; MODELS, CHEMICAL; ONIUM COMPOUNDS; PHOSPHORAMIDE MUSTARDS; PROTEIN ISOFORMS; SPECTROPHOTOMETRY, ULTRAVIOLET; TIME FACTORS;

EID: 47149111396     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.099     Document Type: Article

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