Randomised, double-blinded, placebo-controlled, clinical trial of ozone therapy as treatment of sudden sensorineural hearing loss

Journal of Laryngology and Otology

Volumn 123, Issue 1, 2009, Pages 54-60

  Ragab, A ^a,b   Shreef, E ^a   Behiry, E ^a   Zalat, S ^a   Noaman, M ^a  

^a MENOUFIA UNIVERSITY   (Egypt)

^b Menoufia University Hospital   (Egypt)

Author keywords

Ozone; Sensorineural Hearing Loss; Sudden Hearing Loss

Indexed keywords

OXYGEN; OZONE; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; DOUBLE BLIND PROCEDURE; FEMALE; FUNCTIONAL ASSESSMENT; HEARING; HUMAN; MALE; OZONE THERAPY; PERCEPTION DEAFNESS; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SPEECH AUDIOMETRY; SPEECH DISCRIMINATION; THERAPY EFFECT; TREATMENT DURATION; BLOOD; BLOOD AUTOTRANSFUSION; HOSPITALIZATION; METHODOLOGY; MIDDLE AGED; STATISTICS; SUDDEN DEAFNESS; TREATMENT OUTCOME;

ADULT; BLOOD TRANSFUSION, AUTOLOGOUS; DOUBLE-BLIND METHOD; FEMALE; HEARING LOSS, SENSORINEURAL; HEARING LOSS, SUDDEN; HUMANS; MALE; MIDDLE AGED; OZONE; RECOVERY OF FUNCTION; SEVERITY OF ILLNESS INDEX; STATISTICS AS TOPIC; TREATMENT OUTCOME; YOUNG ADULT;

EID: 64249109722     PISSN: 00222151     EISSN: 17485460     Source Type: Journal    
DOI: 10.1017/S0022215108003770     Document Type: Article

References (33)

1. Byl FM. Sudden hearing loss: Eight years experience and suggested prognostic table. Laryngoscope 1984;94:647-61
2. Simmons FB. Sudden idiopathic sensorineural hearing loss: some observations. Laryngoscope 1973;83:1221-7
3. Wilson WR, Byl FM, Laird N. The efficacy of steriods in the treatment of idiopathic sudden hearing loss. Arch Otolaryngol 1980;106:772-6
4. Wilson WR, Veltri RW, Laird N, Sprinkle PM. Viral and epidemiologic studies of idiopathic sudden hearing loss. Otolaryngol Head Neck Surg 1983;91:653-8
5. Horn CE, Himel HN, Selesnick SH. Hyperbaric oxygen therapy for sudden sensorineural hearing loss: a
6. prospective trial of patients failing steroid and antiviral treatment. Otol Neurotol 2005;26:882-9
7. Simmons FB. Theory of membrane breaks in sudden hearing loss. Arch Otolaryngol 1968;88:41-8
8. Merchant SN, Adams JC, Nadol JB Jr. Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss. Otol Neurotol 2005;26:151 -60
9. Schuknecht HF. Pathology of the Ear, 2nd edn. Philadelphia: Lea & Febiger, 1993
10. Mattox DE, Simmons FB. Natural history of sudden sen- sorineural hearing loss. Ann Otol Rhinol Laryngol 1977; 86:463-80
11. Doyle KJ, Bauch C, Battista R, Beatty C, Hughes GB, Mason J et al. Intratympanic steroid treatment: a review. Otol Neurotol 2004;25:1034-9
12. Travagli V, Zanardi I, Bocci V. A realistic evaluation of the action of ozone on whole human blood. Int J Biol Macro- mol 2006;39:317-20
13. Halliwell B, Clement MV, Long LH. Hydrogen peroxide in the human body. FEBS Lett 2000;486:10-13
14. Bocci VA. Scientific and medical aspects of ozone therapy. State of the art. Arch Med Res 2006;37:425-35
15. MadejP, Plewka A, MadejJA, Nowak M, Plewka D, Franik G et al. Ozonotherapy in an induced septic shock. I. Effect of ozonotherapy on rat organs in evaluation of free radical reactions and selected enzymatic systems. Inflammation 2007;30:52-8
16. Di Paolo N, Bocci V, Salvo DP, Palasciano G, Biagioli M, Meini S et al. Extracorporeal blood oxygenation and ozo- nation (EBOO): a controlled trial in patients with peripheral artery disease. Int J ArtifOrgans 2005;28:1039-50
17. Di Paolo N, Gaggiotti E, Galli F. Extracorporeal blood oxygenation and ozonation: clinical and biological implications of ozone therapy. Redox Rep 2005;10:121-30
18. Weng SF, Chen YS, Hsu CJ, Tseng FY. Clinical features of sudden sensorineural hearing loss in diabetic patients. Laryngoscope 2005;115:1676-80
19. Eisenman D, Arts HA. Effectiveness of treatment for sudden sensorineural hearing loss. Arch Otolaryngol Head Neck Surg 2000;126:1161 -4
20. Aoki D, Takegoshi H, Kikuchi S. Evaluation of super-high-dose steroid therapy for sudden sensorineural hearing loss. Otolaryngol Head Neck Surg 2006;134:783-7
21. Choung YH, Park K, Shin YR, Cho MJ. Intratympanic
22. dexamethasone injection for refractory sudden sensori- neural hearing loss. Laryngoscope 2006;116:747-52
23. Xenellis J, Papadimitriou N, Nikolopoulos T, Maragouda- kis P, Segas J, Tzagaroulakis A et al. Intratympanic steroid treatment in idiopathic sudden sensorineural hearing loss: a control study. Otolaryngol Head Neck Surg 2006;134:940-5
24. Gianoli GJ, Li JC. Transtympanic steroids for treatment of sudden hearing loss. Otolaryngol Head Neck Surg 2001; 125:142-6
25. Battista RA. Intratympanic dexamethasone for profound idiopathic sudden sensorineural hearing loss. Otolaryngol Head Neck Surg 2005;132:902-5
26. Tucci DL, Farmer JC Jr, Kitch RD, Witsell DL. Treatment of sudden sensorineural hearing loss with systemic steroids and valacyclovir. Otol Neurotol 2002;23:301 -8
27. Uri N, Doweck I, Cohen-Kerem R, Greenberg E. Acyclo- vir in the treatment of idiopathic sudden sensorineural hearing loss. Otolaryngol Head Neck Surg 2003;128:544-9
28. Gordin A, Goldenberg D, Golz A, Netzer A, Joachims HZ. Magnesium: a new therapy for idiopathic sudden sen- sorineural hearing loss. Otol Neurotol 2002;23:447-51
29. Psifidis AD, Psillas GK, Daniilidis JCh. Sudden sensori- neural hearing loss: long-term follow-up results. Otolaryn- gol Head Neck Surg 2006;134:809-15
30. Suzuki H, Furukawa M, Kumagai M, Takahashi E, Matsuura K, Katori Y et al. Defibrinogenation therapy for idiopathic sudden sensorineural hearing loss in comparison with high-dose steroid therapy. Acta Otolaryngol 2003;123:46-50
31. Zadeh MH, Storper IS, Spitzer JB. Diagnosis and treatment of sudden-onset sensorineural hearing loss: a study of 51 patients. Otolaryngol Head Neck Surg 2003;128:92-8
32. Cinamon U, Bendet E, Kronenberg J. Steroids, carbogen or placebo for sudden hearing loss: a prospective double- blind study. Eur Arch Otorhinolaryngol 2001;258:477-80
33. Slattery WH, Fisher LM, Iqbal Z, Friedman RA, Liu N. Intratympanic steroid injection for treatment of idiopathic sudden hearing loss. Otolaryngol Head Neck Surg 2005; 133:251-9