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Volumn 10, Issue 3, 2005, Pages 121-130

Extracorporeal blood oxygenation and ozonation: Clinical and biological implications of ozone therapy

Author keywords

Antioxidants; Extracorporeal circulation; Lipid peroxidation; Oxidative stress; Oxygen; Ozone therapy

Indexed keywords

ALPHA TOCOPHEROL; BIOLOGICAL MARKER; CATALASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; GLUTATHIONE TRANSFERASE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON; INTERLEUKIN 2; INTERLEUKIN 8; MALONALDEHYDE; OXYGEN; OZONE; PLASMA PROTEIN; PLATELET DERIVED GROWTH FACTOR; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOL; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 29244437547     PISSN: 13510002     EISSN: 13510002     Source Type: Journal    
DOI: 10.1179/135100005X38888     Document Type: Review
Times cited : (31)

References (58)
  • 3
    • 0002634439 scopus 로고    scopus 로고
    • General biological consequences of inhaled environmental toxicants
    • Crystal RG, West JB. (eds) Philadelphia, PA: Lippincott-Raven
    • Cross CE, Eiserich, JP, Halliwell B. General biological consequences of inhaled environmental toxicants. In: Crystal RG, West JB. (eds) The Lung: Scientific Foundations. Philadelphia, PA: Lippincott-Raven, 1997; 2421-2437.
    • (1997) The Lung: Scientific Foundations , pp. 2421-2437
    • Cross, C.E.1    Eiserich, J.P.2    Halliwell, B.3
  • 4
    • 0004839856 scopus 로고
    • L'ozone medicale: Production, posologie, models d'applications cliniques
    • Aubourg P. L'ozone medicale: production, posologie, models d'applications cliniques. Bull Med Paris 1938; 52: 745-749.
    • (1938) Bull Med Paris , vol.52 , pp. 745-749
    • Aubourg, P.1
  • 5
    • 0033861235 scopus 로고    scopus 로고
    • Bactericidal properties of ozone and its potential application as a terminal disinfectant
    • Moore G, Griffith C, Peters A. Bactericidal properties of ozone and its potential application as a terminal disinfectant. J Food Prot 2000; 63: 1100-1106.
    • (2000) J Food Prot , vol.63 , pp. 1100-1106
    • Moore, G.1    Griffith, C.2    Peters, A.3
  • 6
    • 0000864635 scopus 로고
    • Die Behandlung perripherer Durchblutungs storungen mit Ozon
    • Wolff HH. Die Behandlung perripherer Durchblutungs storungen mit Ozon. Erfahr Hk 1974; 23: 181-184.
    • (1974) Erfahr Hk , vol.23 , pp. 181-184
    • Wolff, H.H.1
  • 7
    • 0026731614 scopus 로고
    • Ozonization of blood for the therapy of viral disease and immunodeficiencies. A hypothesis
    • Bocci V. Ozonization of blood for the therapy of viral disease and immunodeficiencies. A hypothesis. Med Hypothesis 1992; 39: 30-34.
    • (1992) Med Hypothesis , vol.39 , pp. 30-34
    • Bocci, V.1
  • 8
    • 0027630577 scopus 로고
    • Ozone therapy in the advance stages of arteriosclerosis obliterans
    • Valdes RA, Cepero MS, Moraleda GM, Pozo LJ. Ozone therapy in the advance stages of arteriosclerosis obliterans. Angiologia 1993; 45: 146-148.
    • (1993) Angiologia , vol.45 , pp. 146-148
    • Valdes, R.A.1    Cepero, M.S.2    Moraleda, G.M.3    Pozo, L.J.4
  • 9
    • 33746371979 scopus 로고
    • 2nd edn. Heidelberg: Karl F. Haug
    • Viebahn R. The Use of Ozone in Medicine, vol. 1, 2nd edn. Heidelberg: Karl F. Haug, 1994; 178-181.
    • (1994) The Use of Ozone in Medicine , vol.1 , pp. 178-181
    • Viebahn, R.1
  • 10
    • 0029782304 scopus 로고    scopus 로고
    • Oxidative stress during viral infection: A review
    • Schwarz KB. Oxidative stress during viral infection: a review. Free Radic Biol Med 1996; 21: 641-649.
    • (1996) Free Radic Biol Med , vol.21 , pp. 641-649
    • Schwarz, K.B.1
  • 11
    • 0030417146 scopus 로고    scopus 로고
    • Ozone as bioregulator: Pharmacology and toxicology of ozone-therapy today
    • Bocci V. Ozone as bioregulator: pharmacology and toxicology of ozone-therapy today. J Biol Regular Homeost Agent 1996; 10: 31-53.
    • (1996) J Biol Regular Homeost Agent , vol.10 , pp. 31-53
    • Bocci, V.1
  • 12
    • 0025608708 scopus 로고
    • Studies on the biological effects of ozone: 1. Induction of interferon gamma on human leukocytes
    • Bocci V, Paulesu L. Studies on the biological effects of ozone: 1. Induction of interferon gamma on human leukocytes. Haematologia 1990; 75: 510-515.
    • (1990) Haematologia , vol.75 , pp. 510-515
    • Bocci, V.1    Paulesu, L.2
  • 13
    • 0034072056 scopus 로고    scopus 로고
    • Extracorporeal blood oxygenation and ozonation (EBOO) in man. Preliminary report
    • Di Paolo N, Bocci V, Garosi G et al. Extracorporeal blood oxygenation and ozonation (EBOO) in man. Preliminary report. Int J Artif Organs 2000; 23: 131-141.
    • (2000) Int J Artif Organs , vol.23 , pp. 131-141
    • Di Paolo, N.1    Bocci, V.2    Garosi, G.3
  • 14
    • 0343232666 scopus 로고
    • Physikalisch-chemische, grundlagen der ozontherapie
    • Viebahn R. Physikalisch-chemische, grundlagen der ozontherapie. Erfahrungsheilkunde 1975; 5: 129-134.
    • (1975) Erfahrungsheilkunde , vol.5 , pp. 129-134
    • Viebahn, R.1
  • 15
    • 0004633592 scopus 로고    scopus 로고
    • Ozone therapy may act as a biological response modifier in cancer
    • Bocci V. Ozone therapy may act as a biological response modifier in cancer. Forsch Komplement 1998; 5: 54-60.
    • (1998) Forsch Komplement , vol.5 , pp. 54-60
    • Bocci, V.1
  • 17
    • 0031708118 scopus 로고    scopus 로고
    • Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone
    • Bocci V, Valacchi G, Corradeschi F et al. Studies on the biological effects of ozone: 7. Generation of reactive oxygen species (ROS) after exposure of human blood to ozone. J Biol Regulat Homeost Agent 1998; 12: 67-75.
    • (1998) J Biol Regulat Homeost Agent , vol.12 , pp. 67-75
    • Bocci, V.1    Valacchi, G.2    Corradeschi, F.3
  • 18
    • 0014152971 scopus 로고
    • Effect of ozone on lipid peroxidation in the red blood cell
    • Goldstein BD, Balchum OJ. Effect of ozone on lipid peroxidation in the red blood cell. Proc Soc Exp Biol Med 1967; 126: 356-359.
    • (1967) Proc Soc Exp Biol Med , vol.126 , pp. 356-359
    • Goldstein, B.D.1    Balchum, O.J.2
  • 19
    • 0028950090 scopus 로고
    • Hydrogen peroxide as a potent activator of T-lymphocyte functions
    • Los M, Droge W, Stricker K et al. Hydrogen peroxide as a potent activator of T-lymphocyte functions. Eur J Immunol 1995; 25: 159-165.
    • (1995) Eur J Immunol , vol.25 , pp. 159-165
    • Los, M.1    Droge, W.2    Stricker, K.3
  • 20
    • 0030756676 scopus 로고    scopus 로고
    • The lipid peroxidation end product 4-hydroxy-2,3 nonenal up-regulates transforming growth factor β1 expression in the macrophage lineage: A link between oxidative injury and fibrosclerosis
    • Leonarduzzi G. The lipid peroxidation end product 4-hydroxy-2,3 nonenal up-regulates transforming growth factor β1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis. FASEB J 1997; 11: 851-857.
    • (1997) FASEB J , vol.11 , pp. 851-857
    • Leonarduzzi, G.1
  • 21
    • 0032961201 scopus 로고    scopus 로고
    • Studies on the biological effects of ozone: 9. Effects of ozone on human platelets
    • Bocci V, Valacchi G, Rossi D et al. Studies on the biological effects of ozone: 9. Effects of ozone on human platelets. Platelets 1999; 10: 110-116.
    • (1999) Platelets , vol.10 , pp. 110-116
    • Bocci, V.1    Valacchi, G.2    Rossi, D.3
  • 22
    • 0019860245 scopus 로고
    • Reaction of ozone with sulphydryls of human erythrocytes
    • Freeman BA, Mudd JB. Reaction of ozone with sulphydryls of human erythrocytes. Arch Biochem Biophys 1981; 208: 212-220.
    • (1981) Arch Biochem Biophys , vol.208 , pp. 212-220
    • Freeman, B.A.1    Mudd, J.B.2
  • 23
    • 0029086518 scopus 로고
    • Oxidative damage to extracellular fluids by ozone and possible protective effects of thiols
    • Van der Vliet A, O'Neill CA, Eiserich JP, Cross CE. Oxidative damage to extracellular fluids by ozone and possible protective effects of thiols. Arch Biochem Biophys 1995; 321: 43-50.
    • (1995) Arch Biochem Biophys , vol.321 , pp. 43-50
    • Van der Vliet, A.1    O'Neill, C.A.2    Eiserich, J.P.3    Cross, C.E.4
  • 24
    • 0031708118 scopus 로고    scopus 로고
    • Studies on the biological effects of ozone: 4. Cytokine production and glutathione levels in human erythrocytes
    • Bocci V, Luzzi E, Corradeshi F et al. Studies on the biological effects of ozone: 4. Cytokine production and glutathione levels in human erythrocytes. J Biol Regulat Homeost Agent 1998; 12: 67-75.
    • (1998) J Biol Regulat Homeost Agent , vol.12 , pp. 67-75
    • Bocci, V.1    Luzzi, E.2    Corradeshi, F.3
  • 25
    • 0026858708 scopus 로고
    • Direct stimulation of cytokine (IL-1β, TNF-α, IL-6, IL-2, IFN-g and GM-CFS) in whole blood. I. Comparison with isolate PBMC stimulation
    • De Groote D. Direct stimulation of cytokine (IL-1β, TNF-α, IL-6, IL-2, IFN-g and GM-CFS) in whole blood. I. Comparison with isolate PBMC stimulation. Cytokine 1992; 4: 239-248.
    • (1992) Cytokine , vol.4 , pp. 239-248
    • De Groote, D.1
  • 26
    • 0031743701 scopus 로고    scopus 로고
    • Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production
    • Bocci V, Valacchi G, Corradeschi F, Fanetti G. Studies on the biological effects of ozone: 8. Effects on the total antioxidant status and on interleukin-8 production. Mediat Inflam 1998; 7: 313-317.
    • (1998) Mediat Inflam , vol.7 , pp. 313-317
    • Bocci, V.1    Valacchi, G.2    Corradeschi, F.3    Fanetti, G.4
  • 27
    • 0030215488 scopus 로고    scopus 로고
    • 4-hydroxynonenal mimics ozone-induced modulation of macrophages function ex vivo
    • Hamilton RF, Hazbun ME, Jumper CA. 4-hydroxynonenal mimics ozone-induced modulation of macrophages function ex vivo. Am J Respir Cell Mol Biol 1996; 15: 275-282.
    • (1996) Am J Respir Cell Mol Biol , vol.15 , pp. 275-282
    • Hamilton, R.F.1    Hazbun, M.E.2    Jumper, C.A.3
  • 28
    • 0030898845 scopus 로고    scopus 로고
    • Ozone-induced IL-8 expression and transcription factor binding in respiratory epithelial cells
    • Jaspers I, Flescher E, Chen LC. Ozone-induced IL-8 expression and transcription factor binding in respiratory epithelial cells. Am J Physiol 1997; 272: 504-511.
    • (1997) Am J Physiol , vol.272 , pp. 504-511
    • Jaspers, I.1    Flescher, E.2    Chen, L.C.3
  • 29
    • 0022260280 scopus 로고
    • Quantitative measurement of the total, peroxyl radical-trapping antioxidant capability of human blood plasma by controlled peroxidation
    • Wainer DDM, Burton GW, Ingold KU, Locke S. Quantitative measurement of the total, peroxyl radical-trapping antioxidant capability of human blood plasma by controlled peroxidation. FEBS Lett 1985; 187: 33-37.
    • (1985) FEBS Lett , vol.187 , pp. 33-37
    • Wainer, D.D.M.1    Burton, G.W.2    Ingold, K.U.3    Locke, S.4
  • 30
    • 0028840467 scopus 로고
    • The cascade mechanism to explain ozone toxicity: The role of lipid ozonation products
    • Pryor WA, Squadrito GL, Friedman M. The cascade mechanism to explain ozone toxicity: The role of lipid ozonation products. Free Radic Biol Med 1995; 19: 935-941.
    • (1995) Free Radic Biol Med , vol.19 , pp. 935-941
    • Pryor, W.A.1    Squadrito, G.L.2    Friedman, M.3
  • 31
    • 0027171266 scopus 로고
    • Oxidants, antioxidants, and the degenerative diseases of aging
    • Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993; 90: 7915-7922.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 7915-7922
    • Ames, B.N.1    Shigenaga, M.K.2    Hagen, T.M.3
  • 32
    • 0029823459 scopus 로고    scopus 로고
    • Lipid mediator networks in cell signaling: Update and impact of cytokines
    • Serhan CN, Haeggstrom JZ, Leslie CC. Lipid mediator networks in cell signaling: update and impact of cytokines. FASEB J 1996; 10; 1147-1158.
    • (1996) FASEB J , vol.10 , pp. 1147-1158
    • Serhan, C.N.1    Haeggstrom, J.Z.2    Leslie, C.C.3
  • 33
    • 0027162834 scopus 로고
    • Studies on the biological effects of ozone: 3. An attempt to define condition for optimal induction of cytokine
    • Bocci V, Luzzi E, Corradeschi F. Studies on the biological effects of ozone: 3. An attempt to define condition for optimal induction of cytokine. Lymphokine Cytokine Res 1993; 12: 121-126.
    • (1993) Lymphokine Cytokine Res , vol.12 , pp. 121-126
    • Bocci, V.1    Luzzi, E.2    Corradeschi, F.3
  • 34
    • 0025216926 scopus 로고
    • Commentary on 'Cellular, biochemical and functional effects of ozone: New research and perspectives on ozone health effects'
    • Hatch GE. Commentary on 'Cellular, biochemical and functional effects of ozone: new research and perspectives on ozone health effects'. Toxicol Lett 1990; 51: 119-120.
    • (1990) Toxicol Lett , vol.51 , pp. 119-120
    • Hatch, G.E.1
  • 35
    • 0344304485 scopus 로고    scopus 로고
    • An environmental decision-making tool for evaluating ground-level ozone-related health effects
    • Sanhueza PA, Reed GD, Davis WT, Miller TL. An environmental decision-making tool for evaluating ground-level ozone-related health effects. J Air Waste Manage Assoc 2003; 53: 1448-1459.
    • (2003) J Air Waste Manage Assoc , vol.53 , pp. 1448-1459
    • Sanhueza, P.A.1    Reed, G.D.2    Davis, W.T.3    Miller, T.L.4
  • 36
    • 0019306267 scopus 로고
    • Ozone selectively inhibits growth of human cancer cells
    • Sweet F, Kao MS, Lee S. Ozone selectively inhibits growth of human cancer cells. Science 1980; 209: 931-933.
    • (1980) Science , vol.209 , pp. 931-933
    • Sweet, F.1    Kao, M.S.2    Lee, S.3
  • 37
    • 0028080284 scopus 로고
    • Mechanisms of radical formation from reactions of ozone with target molecules in the lung
    • Pryor WA. Mechanisms of radical formation from reactions of ozone with target molecules in the lung. Free Radic Biol Med 1994; 17: 451-465.
    • (1994) Free Radic Biol Med , vol.17 , pp. 451-465
    • Pryor, W.A.1
  • 38
    • 0035718595 scopus 로고    scopus 로고
    • Ozonation of blood during extracorporeal circulation II. Comparative analysis of several oxygenators-ozonators and selection of one type
    • Bocci V, Di Paolo N, Borrelli E, Larini A, Cappelletti F. Ozonation of blood during extracorporeal circulation II. Comparative analysis of several oxygenators-ozonators and selection of one type, Int J Artif Org 2001; 24: 890-897.
    • (2001) Int J Artif Org , vol.24 , pp. 890-897
    • Bocci, V.1    Di Paolo, N.2    Borrelli, E.3    Larini, A.4    Cappelletti, F.5
  • 39
    • 0032733952 scopus 로고    scopus 로고
    • Ozonation of blood during extracorporeal circulation. I. Rationale, methodology and preliminary studies
    • Bocci V, Di Paolo N, Garosi G et al. Ozonation of blood during extracorporeal circulation. I. Rationale, methodology and preliminary studies. Int J Artif Org 1999; 22: 645-651.
    • (1999) Int J Artif Org , vol.22 , pp. 645-651
    • Bocci, V.1    Di Paolo, N.2    Garosi, G.3
  • 40
    • 2342537102 scopus 로고    scopus 로고
    • Oxygenation and ozonization of blood during extracorporeal circulation. 3. A new medical approach
    • Bocci V, Di Paolo N. Oxygenation and ozonization of blood during extracorporeal circulation. 3. A new medical approach. Ozone Sci Eng 2004; 26: 195-205.
    • (2004) Ozone Sci Eng , vol.26 , pp. 195-205
    • Bocci, V.1    Di Paolo, N.2
  • 41
    • 0346665821 scopus 로고    scopus 로고
    • Necrotizing fasciliitis successfully treated with EBOO (extracorporeal blood oxygenation and ozonization)
    • Di Paolo N, Bocci V, Cappelletti F, Petrini G, Gaggiotti E. Necrotizing fasciliitis successfully treated with EBOO (extracorporeal blood oxygenation and ozonization). Int J Artif Org 2002; 25: 1194-1198.
    • (2002) Int J Artif Org , vol.25 , pp. 1194-1198
    • Di Paolo, N.1    Bocci, V.2    Cappelletti, F.3    Petrini, G.4    Gaggiotti, E.5
  • 42
    • 0027269832 scopus 로고
    • Mistletoe (Viscum album) lectins as cytokine inducers and immunoadjuvant in tumor therapy: A review
    • Bocci V. Mistletoe (Viscum album) lectins as cytokine inducers and immunoadjuvant in tumor therapy: a review. J Biol Regul Homeost Agent 1993; 7: 1-6.
    • (1993) J Biol Regul Homeost Agent , vol.7 , pp. 1-6
    • Bocci, V.1
  • 43
    • 0004863152 scopus 로고
    • Die ozonotherapie bei peripheren, arteriellen Durchblutungs-storungen; klinik, biochemisch und blutgasanalytische Untersuchungen
    • Wasser IAO, Berlin
    • Rokitansky O, Rokitansky A, Steiner J, Trubel W, Viebahn R, Washuttl J. Die ozonotherapie bei peripheren, arteriellen Durchblutungs-storungen; klinik, biochemisch und blutgasanalytische Untersuchungen. In: Wasser IAO, Proceedings of the Ozone-Weltkongress, Berlin 1981; 53-75.
    • (1981) Proceedings of the Ozone-Weltkongress , pp. 53-75
    • Rokitansky, O.1    Rokitansky, A.2    Steiner, J.3    Trubel, W.4    Viebahn, R.5    Washuttl, J.6
  • 44
    • 0023852553 scopus 로고
    • Ozone-initiated changes in erythrocyte membrane and loss of deformability
    • Morgan DL, Furlow TL, Menzel DB. Ozone-initiated changes in erythrocyte membrane and loss of deformability. Environ Res 1988; 45: 108-117.
    • (1988) Environ Res , vol.45 , pp. 108-117
    • Morgan, D.L.1    Furlow, T.L.2    Menzel, D.B.3
  • 45
    • 0032242268 scopus 로고    scopus 로고
    • Susceptibilities of plasma antioxidants and erythrocyte constituents to low levels of ozone
    • Shinriki N, Suzuki T, Takama K et al. Susceptibilities of plasma antioxidants and erythrocyte constituents to low levels of ozone. Haematologia 1998; 29: 229-239.
    • (1998) Haematologia , vol.29 , pp. 229-239
    • Shinriki, N.1    Suzuki, T.2    Takama, K.3
  • 46
    • 0034491088 scopus 로고    scopus 로고
    • Studies on the biological effects of ozone: 11. Release of factors from human endothelial cells
    • Valacchi G, Bocci V. Studies on the biological effects of ozone: 11. Release of factors from human endothelial cells. Mediat Inflamm 2000; 9: 271-276.
    • (2000) Mediat Inflamm , vol.9 , pp. 271-276
    • Valacchi, G.1    Bocci, V.2
  • 47
    • 0028283301 scopus 로고
    • Measurement of protein thiol groups and glutathione in plasma
    • Hu ML. Measurement of protein thiol groups and glutathione in plasma. Methods Enzymol 1994; 233: 380-385.
    • (1994) Methods Enzymol , vol.233 , pp. 380-385
    • Hu, M.L.1
  • 48
    • 0001014795 scopus 로고
    • Microsomal lipid peroxidation
    • Buege JA, Aust SD. Microsomal lipid peroxidation. Methods Enzymol 1994; 233: 302-310.
    • (1994) Methods Enzymol , vol.233 , pp. 302-310
    • Buege, J.A.1    Aust, S.D.2
  • 49
    • 0030963753 scopus 로고    scopus 로고
    • The isoprostanes: Unique bioactive products of lipid peroxidation
    • Morrow JD, Jackson Roberts L. The isoprostanes: unique bioactive products of lipid peroxidation. Prog Lipid Res 1997: 36: 1-21.
    • (1997) Prog Lipid Res , vol.36 , pp. 1-21
    • Morrow, J.D.1    Jackson, R.L.2
  • 50
    • 0842302396 scopus 로고    scopus 로고
    • Isoprostanes: Novel bioactive products of lipid peroxidation
    • Basu S. Isoprostanes: novel bioactive products of lipid peroxidation. Free Radic Res 2004; 38: 105-122.
    • (2004) Free Radic Res , vol.38 , pp. 105-122
    • Basu, S.1
  • 51
    • 0346731074 scopus 로고    scopus 로고
    • Amino acid and protein modifications by oxygen and nitrogen species
    • Galli F. Amino acid and protein modifications by oxygen and nitrogen species. Amino Acids 2003; 25: 205-206.
    • (2003) Amino Acids , vol.25 , pp. 205-206
    • Galli, F.1
  • 53
    • 0037769851 scopus 로고    scopus 로고
    • The influence of ozonated autohemotherapy on oxidative stress in hemodialysed patients with atherosclerotic ischemia of lower limbs
    • Tylicki L, Nieweglowski T, Biedunkiewicz B, Chamienia A, Debska-Slizien A. The influence of ozonated autohemotherapy on oxidative stress in hemodialysed patients with atherosclerotic ischemia of lower limbs. Int J Artif Org 2003; 26: 297-303.
    • (2003) Int J Artif Org , vol.26 , pp. 297-303
    • Tylicki, L.1    Nieweglowski, T.2    Biedunkiewicz, B.3    Chamienia, A.4    Debska-Slizien, A.5
  • 54
    • 2342448892 scopus 로고    scopus 로고
    • Is ozonotherapy therapeutic?
    • Bocci V. Is ozonotherapy therapeutic? Perspect Biol Med 1998; 42: 141-143.
    • (1998) Perspect Biol Med , vol.42 , pp. 141-143
    • Bocci, V.1
  • 55
    • 0025885766 scopus 로고
    • Studies on the biological effects of ozone: 2. Induction of tumor necrosis factor α (TNF-α) on human leukocytes
    • Paulesu L, Luzzi E, Bocci V. Studies on the biological effects of ozone: 2. Induction of tumor necrosis factor α (TNF-α) on human leukocytes. Lymphokyne Cytokine Res 1991; 10: 409-412.
    • (1991) Lymphokyne Cytokine Res , vol.10 , pp. 409-412
    • Paulesu, L.1    Luzzi, E.2    Bocci, V.3
  • 58
    • 85084687862 scopus 로고    scopus 로고
    • Ozone therapy seems to be safe, but is it really clinically effective?
    • Tylicki L. Rutkowski B. Ozone therapy seems to be safe, but is it really clinically effective? Int J Artif Org 2004; 27: 731-732.
    • (2004) Int J Artif Org , vol.27 , pp. 731-732
    • Tylicki, L.1    Rutkowski, B.2


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