Association between plasma osteoprotegerin concentrations and urinary albumin excretion in Type 2 diabetes

Diabetic Medicine

Volumn 26, Issue 4, 2009, Pages 397-403

  Xiang, G D ^a   Pu, J H ^a   Zhao, L S ^a   Sun, H L ^a   Hou, J ^a   Yue, L ^a  

^a WUHAN GENERAL HOSPITAL OF GUANGZHOU COMMAND   (China)

Author keywords

Endothelial dysfunction; Osteoprotegerin; Type 2 diabetes; Urinary albumin excretion

Indexed keywords

ALBUMIN; C REACTIVE PROTEIN; GLUCOSE; OSTEOPROTEGERIN;

ADULT; AGED; ALBUMINURIA; ARTERY BLOOD FLOW; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DOPPLER FLOWMETRY; ENDOTHELIUM; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; MACROALBUMINURIA; MAJOR CLINICAL STUDY; MALE; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN BLOOD LEVEL; RETINOPATHY; URINARY EXCRETION;

ADULT; AGED; ALBUMINURIA; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; DIABETIC NEPHROPATHIES; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; MALE; MIDDLE AGED; OSTEOPROTEGERIN;

EID: 64249092973     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2009.02683.x     Document Type: Article

References (28)

1. Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R et al. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997 89 : 309 319.
2. Dhore CR, Cleutjens JP, Lutgens E, Cleutjens KB, Geusens PP, Kitslaar PJ et al. Differential expression of bone matrix regulatory proteins in human atherosclerotic plaques. Arterioscler Thromb Vasc Biol 2001 21 : 1998 2003.
3. Bucay N, Sarosi I, Dunstan CR, Morony S, Tarpley J, Capparelli C et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998 12 : 1260 1268.
4. Zhang J, Fu M, Myles D, Zhu X, Du J, Cao X et al. PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways. FEBS Lett 2002 521 : 180 184.
5. Malyankar UM, Scatena M, Suchland KL, Yun TJ, Clark EA, Giachelli CM. Osteoprotegerin is an alpha vbeta 3-induced, NF-kappa B-dependent survival factor for endothelial cells. J Biol Chem 2000 275 : 20959 20962.
6. Jono S, Ikari Y, Shioi A, Mori K, Miki T, Hara K et al. Serum osteoprotegerin levels are associated with the presence and severity of coronary artery disease. Circulation 2002 106 : 1192 1194.
7. Schoppet M, Sattler AM, Schaefer JR, Herzum M, Maisch B, Hofbauer LC. Increased osteoprotegerin serum levels in men with coronary artery disease. J Clin Endocrinol Metab 2003 88 : 1024 1028.
8. Knudsen ST, Foss CH, Poulsen PL, Andersen NH, Mogensen CE, Rasmussen LM. Increased plasma concentrations of osteoprotegerin in type 2 diabetic patients with microvascular complications. Eur J Endocrinol 2003 149 : 39 42.
9. Avignon A, Sultan A, Piot C, Elaerts S, Cristol JP, Dupuy AM. Osteoprotegerin is associated with silent coronary artery disease in high-risk but asymptomatic type 2 diabetic patients. Diabetes Care 2005 28 : 2176 2180.
10. Xiang GD, Xu L, Zhao LS, Yue L, Hou J. The relationship between plasma osteoprotegerin and endothelium-dependent arterial dilation in type 2 diabetes. Diabetes 2006 55 : 2126 2131.
11. Rasmussen LM, Tarnow L, Hansen TK, Parving HH, Flyvbjerg A. Plasma osteoprotegerin levels are associated with glycaemic status, systolic blood pressure, kidney function and cardiovascular morbidity in type 1 diabetic patients. Eur J Endocrinol 2006 154 : 78 81.
12. Dinneen SF, Gerstein HC. The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus: a systematic overview of the literature. Arch Intern Med 1997 157 : 1413 1418.
13. Diercks GF, van Boven AJ, Hillege JL, de Jong PE, Rouleau JL, van Gilst WH. The importance of microalbuminuria as a cardiovascular risk indicator. Can J Cardiol 2002 18 : 525 535.
14. Cosson E, Pham I, Valens P, Parries J, Attali JR, Nitenberg A. Impaired coronary endothelium-dependent vasodilation is associated with microalbuminuria in type 2 diabetes and angiographically normal coronary arteries. Diabetes Care 2006 29 : 107 112.
15. Xiang GD, Wu YH. Apolipoprotein e4 allele and endothelium-dependent arterial dilation in type 2 diabetes mellitus without angiopathy. Diabetologia 2003 46 : 514 519.
16. Xiang GD, Wang YL. Regular aerobic exercise training improves endothelium-dependent artery dilation in patients with impaired fasting glucose. Diabetes Care 2004 27 : 801 802.
17. Sattler AM, Schoppet M, Schaefer JR, Hofbauer LC. Novel aspects on RANK ligand and osteoprotegerin in osteoporosis and vascular disease. Calcif Tissue Int 2004 74 : 103 106.
18. Emery JG, McDonnell P, Burke MB, Deen KC, Lyn S, Silverman C et al. Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem 1998 273 : 14363 14367.
19. Kiechl S, Schett G, Wenning G, Redlich K, Oberhollenzer M, Mayr A et al. Osteoprotegerin is a risk factor for progressive atherosclerosis and cardiovascular disease. Circulation 2004 109 : 2175 2180.
20. Min H, Morony S, Sarosi I, Dunstan CR, Capparelli C, Van Scully SG et al. Osteoprotegerin reverses osteoporosis by inhibiting endosteal osteoclasts and prevents vascular calcification by blocking a process resembling osteoclastogenesis. J Exp Med 2000 192 : 463 474.
21. Price PA, June HH, Buckley JR, Williamson MK. Osteoprotegerin inhibits artery calcification induced by warfarin and by vitamin D. Arterioscler Thromb Vasc Biol 2001 21 : 1610 1616.
22. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N et al. Coronary artery disease: association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 2003 23 : 85 89.
23. Hofbauer LC, Shui C, Riggs BL, Dunstan CR, Spelsberg TC, O'Brien T et al. Effects of immunosuppressants on receptor activator of NF-κB ligand and osteoprotegerin production by human osteoblastic and coronary artery smooth muscle cells. Biochem Biophys Res Commun 2001 280 : 334 339.
24. Boneti PO, Lerman LO, Lerman A. Endothelial dysfunction, a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003 23 : 168 175.
25. Brahimi M, Le Clésiau H, Ouazen Z, Soufi K, Michault A, Pariès J et al. Microalbuminuria, a marker of artery rigidity and cardiac dysfunction. Arch Mal Coeur Vaiss 2007 100 : 673 676.
26. Kudlacek S, Schneider B, Woloszczuk W, Pietschmann P, Willvonseder R. Serum levels of osteoprotegerin increase with age in a healthy adult population. Bone 2003 32 : 681 686.
27. Looker HC, Krakoff J, Knowler WC, Bennett PH, Klein R, Hanson RL. Longitudinal studies of incidence and progression of diabetic retinopathy assessed by retinal photography in Pima Indians. Diabetes Care 2003 26 : 320 326.
28. Boelter MC, Gross JL, Canani LH, Costa LA, Lisboa HR, Três GS et al. Proliferative diabetic retinopathy is associated with microalbuminuria in patients with type 2 diabetes. Braz J Med Biol Res 2006 39 : 1033 1039.