Invasive aspergillosis in two liver transplant recipients: Diagnosis by SeptiFast: Case report

Transplant Infectious Disease

Volumn 11, Issue 2, 2009, Pages 175-178

  Steinmann, J ^a   Buer, J ^a   Rath, Peter Michael ^a   Paul, A ^a   Saner, F ^a  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

Galactomannan; Invasive aspergillosis; Liver transplant recipients; PCR; SeptiFast

Indexed keywords

FUNGAL DNA; GALACTOMANNAN; VORICONAZOLE;

ADULT; ANALYTICAL EQUIPMENT; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; CASE REPORT; CLINICAL FEATURE; DIAGNOSTIC ACCURACY; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FOLLOW UP; HUMAN; LIVER TRANSPLANTATION; LUNG LAVAGE; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SERUM;

ANTIGENS, FUNGAL; ASPERGILLOSIS; ASPERGILLUS FUMIGATUS; BRONCHOALVEOLAR LAVAGE FLUID; DNA, FUNGAL; FATAL OUTCOME; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; LIVER TRANSPLANTATION; LUNG DISEASES, FUNGAL; MALE; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; POLYMERASE CHAIN REACTION; POSTOPERATIVE COMPLICATIONS;

EID: 64249084115     PISSN: 13982273     EISSN: 13993062     Source Type: Journal    
DOI: 10.1111/j.1399-3062.2009.00367.x     Document Type: Article

References (19)

1. Singh N, Paterson DL. Aspergillus infections in transplant recipients. Clin Microbiol Rev 2005 18 : 44 69.
2. Richardson M, Lass-Flörl C. Changing epidemiology of systemic fungal infections. Clin Microbiol Infect 2008 14 : 5 24.
3. Oren I, Goldstein N. Invasive pulmonary aspergillosis. Curr Opin Pulm Med 2002 8 : 195 200.
4. Botterel F, Farrugia C, Ichai P, Costa JM, Saliba F, Bretagne S. Real-time PCR on the first galactomannan-positive serum sample for diagnosing invasive aspergillosis in liver transplant recipients. Transpl Infect Dis 2008 10 (5) : 333 338.
5. Fortun J, Martin-Davila P, Alvarez ME, et al. Aspergillus antigenemia sandwich-enzyme immunoassay test as a serodiagnostic method for invasive aspergillosis in liver transplant recipients. Transplantation 2001 71 : 145 149.
6. Kwak EJ, Husain S, Obman A, et al. Efficacy of galactomannan antigen in Platelia aspergillus enzyme immunoassay for diagnosis of invasive aspergillosis in liver tranplant recipients. J Clin Microbiol 2004 42 : 435 438.
7. Badiee P, Kordbacheh P, Alborzi A, et al. Prospective screening in liver transplant recipients by panfungal PCR-ELISA for early diagnosis of invasive fungal infections. Liver Tranpl 2007 13 : 1011 1016.
8. Donnelly JP. Polymerase chain reaction for diagnosing invasive aspergillosis: getting closer but still a ways to go. Clin Infect Dis 2006 42 : 487 489.
9. Singh N, Wagener MM, Cacciarelli TV, et al. Antifungal management practices in liver transplant recipients. Am J Transplant 2008 8 : 426 431.
10. Becker MJ, de Marie S, Willemse D, Verbrugh HA, Bakker-Woudenberg IA. Quantitative galactomannan detection is superior to PCR in diagnosing and monitoring invasive pulmonary aspergillosis in an experimental rat model. J Clin Microbiol 2000 38 : 1434 1438.
11. Khan ZU, Ahmad S, Theyyathel AM. Detection of Aspergillus fumigatus-specific DNA, (1-3)-beta-d-glucan and galactomannan in serum and bronchoalveolar lavage specimens of experimentally infected rats. Mycoses 2008 51 : 129 135.
12. De Pauw B, Walsh TJ, Donnelly JP, et al. Revised definitions of invasive fungal disease from European Organization for Research Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis 2008 46 : 1813 1821.
13. Mancini N, Clerici D, Diotti R, et al. Molecular diagnosis of sepsis in neutropenic patients with haematological malignancies. J Med Microbiol 2008 57 : 601 604.
14. Lehmann LE, Hunfeld KP, Emrich T, et al. A multiplex real-time PCR assay for rapid detection and differentiation of 25 bacterial and fungal pathogens from whole blood samples. Med Microbiol Immunol 2008 197 : 313 324.
15. Saner FH, Olde Damnik SW, Pavlakovic G, et al. Pulmonary and blood stream infections in adult living donor and cadaveric liver transplantation patients. Transplantation 2008 85 : 1564 1568.
16. Buchheidt D, Baust C, Skladny H, et al. Detection of Aspergillus species in blood and bronchoalvoelar lavage samples from immunocompromised patients by means of 2-step polymerase chain reaction: clinical results. Clin Infect Dis 2001 33 : 428 435.
17. Tuon FF. A systematic literature review on the diagnosis of invasive aspergillosis using polymerase chain reaction (PCR) from bronchoalveolar lavage clinical samples. Rev Iberoam Micol 2007 24 : 89 94.
18. Lass-Flörl C, Gunsilius E, Gastl G, Freund M, Dierich MP, Petzer A. Clinical evaluation of Aspergillus-PCR for detection of invasive aspergillosis in immunosuppressed patients. Mycoses 2005 48 : 12 17.
19. Clancy CJ, Jaber RA, Leather HL, et al. Bronchoalveolar lavage galactomannan in diagnosis of invasive pulmonary aspergillosis among solid-organ transplant recipients. J Clin Microbiol 2007 46 : 1759 1765.