Prevalence and Long-term Course of Macro-Aspartate Aminotransferase in Children

Journal of Pediatrics

Volumn 154, Issue 5, 2009, Pages

  Caropreso, Maria ^a   Fortunato, Giuliana ^a,b   Lenta, Selvaggia ^a   Palmieri, Daniela ^a   Esposito, Marianna ^a   Vitale, Dino Franco ^c   Iorio, Raffaele ^a   Vajro, Pietro ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b CEINGE BIOTECNOLOGIE AVANZATE   (Italy)

^c IRCCS   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTATE AMINOTRANSFERASE; MACROGOL;

ADOLESCENT; ADULT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; COURSE EVALUATION; DISEASE ASSOCIATION; ELECTROPHORESIS; ENZYME ACTIVITY; FEMALE; FOLLOW UP; HUMAN; LABORATORY TEST; LONG TERM CARE; MALE; PRESCHOOL CHILD; PREVALENCE; PRIORITY JOURNAL; PROBABILITY; SCHOOL CHILD; SCREENING; STATISTICAL SIGNIFICANCE; SYMPTOM;

ADOLESCENT; ASPARTATE AMINOTRANSFERASES; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; ELECTROPHORESIS; FEMALE; FOLLOW-UP STUDIES; HUMANS; INFANT; MALE; POLYETHYLENE GLYCOLS; PREVALENCE; SENSITIVITY AND SPECIFICITY;

EID: 64149123276     PISSN: 00223476     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpeds.2008.11.010     Document Type: Article

References (27)

1. Davidson D.F., and Watson D.J.M. Macroenzyme detection by polyethylene glycol precipitation. Ann Clin Biochem 40 (2003) 514-520
2. Galasso P.J., Litin S.C., and O'Brien J.F. The macroenzymes: a clinical review. Mayo Clin Proc 68 (1993) 349-354
3. Litin S.C., O'Brien J.F., Pruet S., Forsman R.W., Burritt M.F., Bartholomew L.G., et al. Macroenzyme as a cause of unexplained elevation of aspartate aminotransferase. Mayo Clin Proc 62 (1987) 681-687
4. Remaley A.T., and Wilding P. Macroenzymes: biochemical characterization, clinical significance and laboratory detection. Clin Chem 35 (1989) 2261-2270
5. Konttinen A., Murros J., Ojala K., Salaspuro M., Somer H., and Räsänen J. A new cause of increased aspartate aminotransferase activity. Clin Chim Acta 84 (1978) 145-147
6. Moriyama T., Nobuoka M., and Makino M. Incidence and properties of aspartate aminotransferase-immunoglobulin complexes in patients with a high serum aspartate to alanine aminotransferase ratio. Clin Chim Acta 190 (1990) 47-56
7. Fortunato G., Iorio R., Esposito P., Lofrano M.M., Vegnente A., and Vajro P. Macroenzymes investigation and monitoring in children with persistent increase of aspartate aminotransferase of unexplained origin. J Pediatr 133 (1998) 286-289
8. Perrault J., O'Brien J.F., and Tremaine W.J. Macrotransaminase of aspartate aminotransferase (AST): a benign cause of elevated AST activity. J Pediatr 117 (1990) 444-445
9. Vajro P., Lofrano M.M., Fontanella A., and Fortunato G. Immunoglobulin complexed AST ("Macro-AST") in an asymptomatic child with persistent hypertransaminasemia. J Pediatr Gastroenterol Nutr 15 (1992) 458-460
10. Tajiiri H., Nakano T., Kozaiwa K., Harada T., Okada S., Fushimi R., et al. Immunoglobulin-complexed aspartate aminotransferase with a possible association with ulcerative colitis and its activity. J Clin Lab Immunol 38 (1992) 41-49
11. Matama S., Hitoshi I., Tanabe S., Shibuya A., Shibata H., Saigenji K., et al. Immunoglobulin-complexed aspartate aminotransferase. Intern Med 32 (1993) 156-159
12. Agbo-Kpati P., Frossard C., Ballesta M., Devanlay M., and Demersay C. Augmentation persistente et isolee des transaminases (aspartate aminotransferase) liee a une macroenzyme [letter]. Arch Pediatr 6 (1999) 590-591
13. Monfort-Gourad M., Hamza A., Nacer K., Barjonnet G., Tranie V., Devanlay M., et al. Hypertransaminasemia in adolescents. Arch Pediatr 6 (1999) 1191-1192
14. Wiltshire E.J., Crooke N., and Grimwood K. Macro-AST: a benign cause of persistently elevated aspartate aminotransferase. J Paediatr Child Health 40 (2004) 642-643
15. Cabrera-Abreu J., Jain R., Robinson P., Edees S., and Staughton T. A case of aspartate aminotransferase macroenzyme. Ann Clin Biochem 45 (2008) 320-322
16. Lord R., Fahie-Wilson M., and Suri S. A paediatric case of macro aspartate aminotransferase. Ann Clin Biochem 45 (2008) 323-324
17. Mari T., Morini S., Zullo A., and Marignani M. Macroenzyme: do not forget liver function tests [letter]. Dig Liver Dis 35 (2003) 673
18. Sass D.A., Chadalavada R., and Virji M.A. Unexplained isolated elevation in serum aspartate aminotransferase: think macro! [letter]. Am J Med 120 (2007) e5-e6
19. Briani C., Zaninotto M., Forni M., and Burra P. Macroenzymes: too often overlooked [letter]. J Hepatol 38 (2003) 119
20. Schumann G., Bonora R., Ceriotti F., Ferard G., Ferrero C.A., Franck P.F.H., et al. IFCC primary reference procedures for the measurements of catalytic activity concentrations of enzymes at 37°C-part 5. Reference procedures for the measurements of catalytic activity concentrations of aspartate aminotransferase. Clin Chem Lab Med 40 (2002) 725-733
21. Sakakibara S., Katsuhiko S., Kobayashi S., Ikeda T., Inai S., and Kagamiyama H. A convenient and sensitive method for the determination of serum aspartate aminotransferase isoenzymes after electrophoresis. Clin Chim Acta 133 (1983) 119-123
22. Levitt M.D., and Ellis C. A rapid and simple assay to determine if macroamylase is the cause of hyperamylasemia. Gastroenterology 83 (1982) 378-382
23. Metz C.E. Basic principles of ROC analysis. Semin Nucl Med 8 (1978) 283-298
24. Afifi A.A., and Clark V. Computer-aided multivariate analysis. In: Afifi A.A., and Clark V. (Eds). Applications of logistic regression (1990), Van Nostrand Reinhold, New York 332-335
25. Bock J., and Afifi A.A. Estimation of probabilities using the logistic model in retrospective studies. Comput Biomed Res 21 (1988) 449-470
26. Orlando R., Carbone A., and Lirussi F. Macro-aspartate aminotransferase (macro-AST). A 12-year follow-up study in a young female. Eur J Gastroenterol Hepatol 15 (2003) 1371-1373
27. Fahie-Wilson M., and Halsall D. Polyethylene glycol precipitation: proceed with care. Ann Clin Biochem 45 (2008) 233-235