Macro-aspartate aminotransferase (macro-AST). A 12-year follow-up study in a young female

European Journal of Gastroenterology and Hepatology

Volumn 15, Issue 12, 2003, Pages 1371-1373

  Orlando, Rocco ^a   Carbone, Aniello ^b   Lirussi, Flavio ^a  

^a UNIVERSITY OF PADOVA   (Italy)

^b Gagliano del Capo Hospital   (Italy)

Author keywords

Aspartate aminotransferase; Hepatic disease; Immunoglobulins; Liver function tests; Macro AST; Macroenzymes

Indexed keywords

ASPARTATE AMINOTRANSFERASE;

ADULT; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; AUTOIMMUNE DISEASE; BIOCHEMISTRY; CASE REPORT; CHRONIC HEPATITIS; DIAGNOSTIC PROCEDURE; DIFFERENTIAL DIAGNOSIS; ENZYME ACTIVITY; FEMALE; FOLLOW UP; HUMAN; LIVER CANCER; PRIORITY JOURNAL;

ADULT; ALANINE TRANSAMINASE; ANTIGEN-ANTIBODY COMPLEX; ASPARTATE AMINOTRANSFERASES; FEMALE; FOLLOW-UP STUDIES; HUMANS; PROGNOSIS;

EID: 3142546036     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-200312000-00018     Document Type: Article

References (16)

1. Collins J, Ritter D, Bacon BR, Landt M, Creer MH. Macro-aspartate aminotransferase in a female with antibodies to hepatitis C virus. Liver 2002; 22:501-506.
2. Galasso PJ, Litin SC, O'Brien JF. The macroenzymes: a clinical review. Mayo Clin Proc 1993; 68:349-354.
3. Monfort-Gouraud M, Hamza A, Nacer K, Barjonnet G, Tranie V, Devanlay M, Sauvageon G. Macrotransaminasémie chez un adolescent. Arch Pediatr 1999; 6:1191-1192.
4. Onuigbo M, Yin R. Macro-aspartate transaminasemia: the macroenzyme phenomenon as a diagnostic dilemma. Mayo Clin Proc 2000; 75:1223-1224.
5. Moryiama T, Nobuoka M, Makino M. Incidence and properties of aspartate aminotransferase-immunoglobulin complexes in patients with a high serum aspartate to alanine aminotransferase ratio. Clin Chim Acta 1990; 190:47-56.
6. Tharakan J, Hossenbocus A, Arthur MJP. Macromolecular aspartate aminotransferase. Eur J Gastroenterol Hepatol 1998; 10:1055-1056.
7. Sanchez-Munoz D, Romero-Gomez M, Moro A. Macro-AST as cause of unknown hypertransaminasaemia. Eur J Gastroenterol Hepatol 2003; 15:103-104.
8. Litin SC, O'Brien JF, Pruett S, Forsman RW, Burritt MF, Bartholemew LG, Baldus WP. Macroenzyme as a cause of unexplained elevation of aspartate aminotransferase. Mayo Clin Proc 1987; 62:681-687.
9. De Jonge N, Houwing A. Unexplained high activity of aspartate aminotransferase (EC 2.6.1.1.): a case report. Neth J Med 1996; 48:224-226.
10. Klonoff DC. Macroamylasemia and other immunoglobulin complexed enzyme disorders. West J Med 1980; 133:392-407.
11. Remaley AT, Wilding P. Macroenzymes: biochemical characterization, clinical significance and laboratory detection. Clin Chem 1989; 35:2261-2270.
12. Stasia MJ, Surla A, Renversez JC, Pene F, Morel-Femelez A, Morel F. Aspartate aminotransferase macroenzyme complex in serum identified and characterized. Clin Chem 1994; 40:1340-1343.
13. Fortunato G, Iorio R, Esposito P, Lofrano MM, Vegnente A, Vajro P. Macroenzyme investigation and monitoring in children with persistent increase of aspartate aminotransferase of unexplained origin. J Pediatr 1998; 133:286-289.
14. Perrault J, O'Brien JF, Tremanine WT. Macrotransaminase of aspartate aminotransferase (AST): a benign cause of elevated AST activity. J Pediatr 1990; 117:444-445.
15. Vajro P, Lofrano MM, Fontanella A, Fortunato G. Immunoglobulin complexed AST ('Macro-AST') in an asymptomatic child with persistent hypertransaminasemia. J Pediatr Gastroenterol Nutr 1992; 15:458-460.
16. Briani C, Zaninotto M, Forni M, Burra P. Macroenzymes: too often overlooked. J Hepatol 2003; 38:119.