Techniques to study nephron function: Microscopy and imaging

Pflugers Archiv European Journal of Physiology

Volumn 458, Issue 1, 2009, Pages 203-209

  Molitoris, Bruce A ^a   Sandoval, Ruben M ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Endocytosis; Imaging; Kidney; Membrane; Microscopy

Indexed keywords

FLUORESCENT DYE;

ARTICLE; BLOOD VESSEL PERMEABILITY; CELLULAR DISTRIBUTION; DIGITAL IMAGING; ERYTHROCYTE; FLOW RATE; GLOMERULUS FILTRATION; IMAGE PROCESSING; INTERNALIZATION; KIDNEY FUNCTION; MULTIPHOTON MICROSCOPY; NEPHRON; NONHUMAN; PRIORITY JOURNAL; TRANSCYTOSIS;

ANIMALS; CAPILLARY PERMEABILITY; DIAGNOSTIC IMAGING; ENDOCYTOSIS; FOLIC ACID; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSCOPY; MICROSCOPY, FLUORESCENCE, MULTIPHOTON; NEPHRONS; RHODAMINES;

EID: 64149109486     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-008-0629-8     Document Type: Article

References (36)

1. SL Ashworth GA Tanner 2006 Fluorescent labeling of renal cells in vivo Nephron Physiol 103 91 96
2. SJ Atkinson 2006 Functional intravital imaging of leukocytes in animal models of renal injury Nephron Physiol 103 86 90
3. EB Brown RB Campbell Y Tsuzuki L Xu P Carmeliet D Fukumura RK Jain 2001 In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy Nat Med 7 864 868
4. JL Clendenon JM Byars DP Hyink 2006 Image processing software for 3D light microscopy Nephron Exp Nephrol 103 e50 e54
5. JL Clendenon CL Phillips RM Sandoval S Fang KW Dunn 2002 Voxx: a PC-based, near real-time volume rendering system for biological microscopy Am J Physiol Cell Physiol 282 C213 C228
6. KW Dunn TE McGraw FR Maxfield 1989 Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome J Cell Biol 109 3303 3314
7. KW Dunn RM Sandoval KJ Kelly PC Dagher GA Tanner SJ Atkinson RL Bacallao BA Molitoris 2002 Functional studies of the kidney of living animals using multicolor two-photon microscopy Am J Physiol Cell Physiol 283 C905 C916
8. KW Dunn RM Sandoval BA Molitoris 2003 Intravital imaging of the kidney using multiparameter multiphoton microscopy Nephron Exp Nephrol 94 e7 e11
9. KW Dunn PA Young 2006 Principles of multiphoton microscopy Nephron Exp Nephrol 103 e33 e40
10. D Gerlich J Ellenberg 2003 4D imaging to assay complex dynamics in live specimens Nat Cell Biol 5 Suppl S14 S19
11. BN Giepmans SR Adams MH Ellisman RY Tsien 2006 The fluorescent toolbox for assessing protein location and function Science 312 217 224
12. AK Hadjantonakis ME Dickinson SE Fraser VE Papaioannou 2003 Technicolour transgenics: imaging tools for functional genomics in the mouse Nat Rev Genet 4 613 625
13. F Helmchen W Denk 2005 Deep tissue two-photon microscopy Nat Methods 2 932 940
14. M Horbelt C Wotzlaw TA Sutton BA Molitoris T Philipp A Kribben J Fandrey F Pietruck 2007 Organic cation transport in the rat kidney in vivo visualized by time-resolved two-photon microscopy Kidney Int 72 422 429
15. KJ Kelly Z Plotkin SL Vulgamott PC Dagher 2003 P53 mediates the apoptotic response to GTP depletion after renal ischemia-reperfusion: protective role of a p53 inhibitor J Am Soc Nephrol 14 128 138
16. KJ Kelly RM Sandoval KW Dunn BA Molitoris PC Dagher 2003 A novel method to determine specificity and sensitivity of the TUNEL reaction in the quantitation of apoptosis Am J Physiol Cell Physiol 284 C1309 C1318
17. A Miyawaki A Sawano T Kogure 2003 Lighting up cells: labelling proteins with fluorophores Nat Cell Biol 5 Suppl S1 S7
18. BA Molitoris RM Sandoval 2005 Intravital multiphoton microscopy of dynamic renal processes Am J Physiol Renal Physiol 288 F1084 F1089
19. BA Molitoris RM Sandoval 2006 Pharmacophotonics: utilizing multi-photon microscopy to quantify drug delivery and intracellular trafficking in the kidney Adv Drug Deliv Rev 58 809 823
20. J Peti-Peterdi 2005 Multiphoton imaging of renal tissues in vitro Am J Physiol Renal Physiol 288 F1079 F1083
21. J Peti-Peterdi A Fintha AL Fuson A Tousson RH Chow 2004 Real-time imaging of renin release in vitro Am J Physiol Renal Physiol 287 F329 F335
22. CL Phillips VH Gattone 2nd SM Bonsib 2006 Imaging glomeruli in renal biopsy specimens Nephron Physiol 103 75 81
23. CL Phillips KJ Miller AJ Filson J Nurnberger JL Clendenon GW Cook KW Dunn PA Overbeek VH Gattone 2nd RL Bacallao 2004 Renal cysts of inv/inv mice resemble early infantile nephronophthisis J Am Soc Nephrol 15 1744 1755
24. RM Sandoval MD Kennedy PS Low BA Molitoris 2004 Uptake and trafficking of fluorescent conjugates of folic acid in intact kidney determined using intravital two-photon microscopy Am J Physiol Cell Physiol 287 C517 C526
25. NC Shaner PA Steinbach RY Tsien 2005 A guide to choosing fluorescent proteins Nat Methods 2 905 909
26. TA Sutton M Horbelt RM Sandoval 2006 Imaging vascular pathology Nephron Physiol 103 82 85
27. TA Sutton KJ Kelly HE Mang Z Plotkin RM Sandoval PC Dagher 2005 Minocycline reduces renal microvascular leakage in a rat model of ischemic renal injury Am J Physiol Renal Physiol 288 F91 F97
28. TA Sutton HE Mang SB Campos RM Sandoval MC Yoder BA Molitoris 2003 Injury of the renal microvascular endothelium alters barrier function after ischemia Am J Physiol Renal Physiol 285 F191 F198
29. GA Tanner RM Sandoval BA Molitoris JR Bamburg SL Ashworth 2005 Micropuncture gene delivery and intravital two-photon visualization of protein expression in rat kidney Am J Physiol Renal Physiol 289 F638 F643
30. AG Teschemacher JF Paton S Kasparov 2005 Imaging living central neurones using viral gene transfer Adv Drug Deliv Rev 57 79 93
31. P van Roessel AH Brand 2002 Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins Nat Cell Biol 4 E15 E20
32. C Xu W Zipfel JB Shear RM Williams WW Webb 1996 Multiphoton fluorescence excitation: new spectral windows for biological nonlinear microscopy Proc Natl Acad Sci USA 93 10763 10768
33. W Yu 2006 Quantitative microscopic approaches for studying kidney functions Nephron Physiol 103 63 70
34. W Yu RM Sandoval BA Molitoris 2004 A new concept of measuring glomerular permeability and molecular filtration rate in vivo with a fluorescence microscope (Abstract) J Am Soc Nephrol 15 211A
35. W Yu RM Sandoval BA Molitoris 2005 Quantitative intravital microscopy using a Generalized Polarity concept for kidney studies Am J Physiol Cell Physiol 289 C1197 C1208
36. WR Zipfel RM Williams WW Webb 2003 Nonlinear magic: multiphoton microscopy in the biosciences Nat Biotechnol 21 1369 1377