Stochastically determined directed movement explains the dominant small-scale mitochondrial movements within non-neuronal tissue culture cells

FEBS Letters

Volumn 583, Issue 8, 2009, Pages 1267-1273

  Saunter, Christopher D ^a   Perng, Ming Der ^a   Love, Gordon D ^a   Quinlan, Roy A ^a  

^a DURHAM UNIVERSITY   (United Kingdom)

Author keywords

Brownian diffusion; Computer aided analysis; Directed movement; Docked anchored mitochondria; Mitochondria; Single particle tracking

Indexed keywords

ANIMAL CELL; ARTICLE; BROWNIAN DIFFUSION; CELL LABELING; CELL MOTION; COMPUTER ANALYSIS; COMPUTER PROGRAM; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DIFFUSION; EPITHELIUM CELL; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; STOCHASTIC MODEL;

ANIMALS; CELL LINE; DIPODOMYS; HUMANS; MICROSCOPY, CONFOCAL; MITOCHONDRIA; STOCHASTIC PROCESSES; TISSUE CULTURE TECHNIQUES;

EID: 64049106883     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.02.041     Document Type: Article

References (30)

1. Soltys B.J., and Gupta R.S. Interrelationships of endoplasmic reticulum, mitochondria, intermediate filaments, and microtubules - a quadruple fluorescence labeling study. Biochem. Cell Biol. 70 (1992) 1174-1186
2. Leopold P.L., McDowall A.W., Pfister K.K., Bloom G.S., and Brady S.T. Association of kinesin with characterized membrane-bounded organelles. Cell Motil. Cytoskeleton 23 (1992) 19-33
3. Nangaku M., Sato-Yoshitake R., Okada Y., Noda Y., Takemura R., Yamazaki H., and Hirokawa N. KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell 79 (1994) 1209-1220
4. Varadi A., Johnson-Cadwell L.I., Cirulli V., Yoon Y., Allan V.J., and Rutter G.A. Cytoplasmic dynein regulates the subcellular distribution of mitochondria by controlling the recruitment of the fission factor dynamin-related protein-1. J. Cell Sci. 117 (2004) 4389-4400
5. Salmeen I., Zacmanidis P., Jesion G., and Feldkamp L.A. Motion of mitochondria in cultured cells quantified by analysis of digitized images. Biophys. J. 48 (1985) 681-686
6. Miller K.E., and Sheetz M.P. Direct evidence for coherent low velocity axonal transport of mitochondria. J. Cell Biol. 173 (2006) 373-381
7. Chada S.R., and Hollenbeck P.J. Nerve growth factor signaling regulates motility and docking of axonal mitochondria. Curr. Biol. 14 (2004) 1272-1276
8. Wagner O.I., Lifshitz J., Janmey P.A., Linden M., McIntosh T.K., and Leterrier J.F. Mechanisms of mitochondria-neurofilament interactions. J. Neurosci. 23 (2003) 9046-9058
9. Winter L., Abrahamsberg C., and Wiche G. Plectin isoform 1b mediates mitochondrion-intermediate filament network linkage and controls organelle shape. J. Cell Biol. 181 (2008) 903-911
10. De Vos K.J., and Sheetz M.P. Visualization and quantification of mitochondrial dynamics in living animal cells. Meth. Cell Biol. 80 (2007) 627-682
11. Muller M.J., Klumpp S., and Lipowsky R. Tug-of-war as a cooperative mechanism for bidirectional cargo transport by molecular motors. Proc. Natl. Acad. Sci. USA 105 (2008) 4609-4614
12. Levi V., Serpinskaya A.S., Gratton E., and Gelfand V. Organelle transport along microtubules in Xenopus melanophores: evidence for cooperation between multiple motors. Biophys. J. 90 (2006) 318-327
13. De Vos K.J., Sable J., Miller K.E., and Sheetz M.P. Expression of phosphatidylinositol (4,5) bisphosphate-specific pleckstrin homology domains alters direction but not the level of axonal transport of mitochondria. Mol. Biol. Cell 14 (2003) 3636-3649
14. Morris R.L., and Hollenbeck P.J. Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons. J. Cell Biol. 131 (1995) 1315-1326
15. Muller M., Mironov S.L., Ivannikov M.V., Schmidt J., and Richter D.W. Mitochondrial organization and motility probed by two-photon microscopy in cultured mouse brainstem neurons. Exp. Cell Res. 303 (2005) 114-127
16. Einstein A. Über die von der molekularkinetischen Theorie der Wärme geforderte Bewegung von in ruhenden Flüssigkeiten suspendierten Teilchen. Ann. Phys. 17 (1905) 549-560
17. Miller K.E., and Sheetz M.P. Axonal mitochondrial transport and potential are correlated. J. Cell Sci. 117 (2004) 2791-2804
18. Chang D.T., Honick A.S., and Reynolds I.J. Mitochondrial trafficking to synapses in cultured primary cortical neurons. J. Neurosci. 26 (2006) 7035-7045
19. Chang D.T., and Reynolds I.J. Differences in mitochondrial movement and morphology in young and mature primary cortical neurons in culture. Neuroscience 141 (2006) 727-736
20. Brickley K., Smith M.J., Beck M., and Stephenson F.A. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. J. Biol. Chem. 280 (2005) 14723-14732
21. Fransson A., Ruusala A., and Aspenstrom P. Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis. J. Biol. Chem. 278 (2003) 6495-6502
22. Glater E.E., Megeath L.J., Stowers R.S., and Schwarz T.L. Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent. J. Cell Biol. 173 (2006) 545-557
23. Guo X., et al. The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses. Neuron 47 (2005) 379-393
24. Smith M.J., Pozo K., Brickley K., and Stephenson F.A. Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes. J. Biol. Chem. 281 (2006) 27216-27228
25. Stowers R.S., Megeath L.J., Gorska-Andrzejak J., Meinertzhagen I.A., and Schwarz T.L. Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein. Neuron 36 (2002) 1063-1077
26. Horiuchi D., Barkus R.V., Pilling A.D., Gassman A., and Saxton W.M. APLIP1, a kinesin binding JIP-1/JNK scaffold protein, influences the axonal transport of both vesicles and mitochondria in Drosophila. Curr. Biol. 15 (2005) 2137-2141
27. Pilling A.D., Horiuchi D., Lively C.M., and Saxton W.M. Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons. Mol. Biol. Cell 17 (2006) 2057-2068
28. Boldogh I.R., and Pon L.A. Mitochondria on the move. Trends Cell Biol. 17 (2007) 502-510
29. Frederick R.L., and Shaw J.M. Moving mitochondria: establishing distribution of an essential organelle. Traffic 8 (2007) 1668-1675
30. Capetanaki Y., Bloch R.J., Kouloumenta A., Mavroidis M., and Psarras S. Muscle intermediate filaments and their links to membranes and membranous organelles. Exp. Cell Res. 313 (2007) 2063-2076