Application of Carbon-Ion Beams or Gamma-Rays on Primary Tumors Does Not Change the Expression Profiles of Metastatic Tumors in an In Vivo Murine Model

International Journal of Radiation Oncology Biology Physics

Volumn 74, Issue 1, 2009, Pages 210-218

  Tamaki, Tomoaki ^a,b   Iwakawa, Mayumi ^a   Ohno, Tatsuya ^a   Imadome, Kaori ^a   Nakawatari, Miyako ^a   Sakai, Minako ^a   Tsujii, Hirohiko ^a   Nakano, Takashi ^b   Imai, Takashi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Carbon ion radiotherapy; Lung metastasis; Microarray analysis; Mouse model; NR S1

Indexed keywords

BRAGG PEAKS; CLUSTERING ANALYSIS; DISTANT METASTASIS; EXPRESSION PROFILES; GAMMA-RAYS; HISTOLOGIC ANALYSIS; IN-VIVO; LUNG METASTASIS; METASTATIC TUMORS; MICROARRAY ANALYSIS; MOUSE MODEL; MURINE MODELS; NR-S1; REFERENCE BEAMS; SINGLE DOSE; SQUAMOUS CELL CARCINOMAS; TRANSCRIPTIONAL CHANGES; TUMOR CELLS; TUMOR GROWTHS;

APPLICATIONS; BIOLOGICAL ORGANS; CESIUM; HEAVY IONS; ONCOLOGY; PATHOLOGY; RADIOTHERAPY;

TUMORS;

CESIUM 137;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER MODEL; CONTROLLED STUDY; GAMMA RADIATION; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; IN VIVO STUDY; INCIDENCE; ION THERAPY; LUNG METASTASIS; LUNG NODULE; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SQUAMOUS CELL CARCINOMA; TUMOR CELL;

ANIMALS; CARBON RADIOISOTOPES; CARCINOMA, SQUAMOUS CELL; GAMMA RAYS; LUNG NEOPLASMS; MALE; MICE; MICE, INBRED C3H; NEOPLASMS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RADIOTHERAPY DOSAGE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; TIME FACTORS; TUMOR BURDEN;

EID: 64049100365     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.12.078     Document Type: Article

References (29)

1. Steeg P.S. Tumor metastasis: Mechanistic insights and clinical challenges. Nat Med 12 (2006) 895-904
2. Eccles S.A., and Welch D.R. Metastasis: Recent discoveries and novel treatment strategies. Lancet 369 (2007) 1742-1757
3. von Essen C.F. Radiation enhancement of metastasis: A review. Clin Exp Metastasis 9 (1991) 77-104
4. Ito H., Shigematsu N., Nishiguchi I., et al. Experimental studies on metastases from an irradiated tumor. [Japanese with English abstract]. Nippon Igaku Hoshasen Gakkai Zasshi 52 (1992) 830-837
5. Rofstad E.K., Mathiesen B., and Galappathi K. Increased metastatic dissemination in human melanoma xenografts after subcurative radiation treatment: Radiation-induced increase in fraction of hypoxic cells and hypoxia-induced up-regulation of urokinase-type plasminogen activator receptor. Cancer Res 64 (2004) 13-18
6. Schulz-Ertner D., and Tsujii H. Particle radiation therapy using proton and heavier ion beams. J Clin Oncol 25 (2007) 953-964
7. Tsujii H., Mizoe J., Kamada T., et al. Clinical results of carbon ion radiotherapy at NIRS. J Radiat Res (Tokyo) 48 Suppl. A (2007) A1-A13
8. Mizoe J.E., Tsujii H., Kamada T., et al. Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys 60 (2004) 358-364
9. Miyamoto T., Baba M., Yamamoto N., et al. Curative treatment of Stage I non-small-cell lung cancer with carbon ion beams using a hypofractionated regimen. Int J Radiat Oncol Biol Phys 67 (2007) 750-758
10. Kato H., Tsujii H., Miyamoto T., et al. Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis. Int J Radiat Oncol Biol Phys 59 (2004) 1468-1476
11. Kato S., Ohno T., Tsujii H., et al. Dose escalation study of carbon ion radiotherapy for locally advanced carcinoma of the uterine cervix. Int J Radiat Oncol Biol Phys 65 (2006) 388-397
12. Ishikawa H., Tsuji H., Kamada T., et al. Carbon ion radiation therapy for prostate cancer: Results of a prospective phase II study. Radiother Oncol 81 (2006) 57-64
13. Kamada T., Tsujii H., Tsuji H., et al. Efficacy and safety of carbon ion radiotherapy in bone and soft tissue sarcomas. J Clin Oncol 20 (2002) 4466-4471
14. Ogata T., Teshima T., Kagawa K., et al. Particle irradiation suppresses metastatic potential of cancer cells. Cancer Res 65 (2005) 113-120
15. Goetze K., Scholz M., Taucher-Scholz G., et al. The impact of conventional and heavy ion irradiation on tumor cell migration. in vitro. Int J Radiat Biol 83 (2007) 889-896
16. Hao X., Sun B., Hu L., et al. Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis. Cancer 100 (2004) 1110-1122
17. Chen Z., Zhang K., Zhang X., et al. Comparison of gene expression between metastatic derivatives and their poorly metastatic parental cells implicates crucial tumor-environment interaction in metastasis of head and neck squamous cell carcinoma. Clin Exp Metastasis 20 (2003) 335-342
18. Ki D.H., Jeung H.C., Park C.H., et al. Whole genome analysis for liver metastasis gene signatures in colorectal cancer. Int J Cancer 121 (2007) 2005-2012
19. Camphausen K., Purow B., Sproull M., et al. Orthotopic growth of human glioma cells quantitatively and qualitatively influences radiation-induced changes in gene expression. Cancer Res 65 (2005) 10389-10393
20. Cook J.A., Chuang E.Y., Tsai M.H., et al. Radiation-induced changes in gene-expression profiles for the SCC VII tumor cells grown in vitro and in vivo. Antioxid Redox Signal 8 (2006) 1263-1272
21. Usui S., Urano M., Koike S., et al. Effect of PS-K, a protein polysaccharide, on pulmonary metastases of a C3H mouse squamous cell carcinoma. J Natl Cancer Inst 56 (1976) 185-187
22. Imadome K., Iwakawa M., Nojiri K., et al. Upregulation of stress-response genes with cell cycle arrest induced by carbon ion irradiation in multiple murine tumors models. Cancer Biol Ther 7 (2008) 208-217
23. Kanai T., Endo M., Minohara S., et al. Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int J Radiat Oncol Biol Phys 44 (1999) 201-210
24. Hill R.P., and Bush R.S. A lung-colony assay to determine the radiosensitivity of cells of a solid tumour. Int J Radiat Biol Relat Stud Phys Chem Med 15 (1969) 435-444
25. Iwakawa M., Ohno T., Imadome K., et al. The radiation-induced cell-death signaling pathway is activated by concurrent use of cisplatin in sequential biopsy specimens from patients with cervical cancer. Cancer Biol Ther 6 (2007) 905-911
26. Baumann M., Suit H.D., and Sedlacek R.S. Metastases after fractionated radiation therapy of three murine tumor models. Int J Radiat Oncol Biol Phys 19 (1990) 367-370
27. Nakamura T., Fidler I.J., and Coombes K.R. Gene expression profile of metastatic human pancreatic cancer cells depends on the organ microenvironment. Cancer Res 67 (2007) 139-148
28. Hiratsuka S., Watanabe A., Aburatani H., et al. Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 8 (2006) 1369-1375
29. Decock J., Hendrickx W., Vanleeuw U., et al. Plasma MMP1 and MMP8 expression in breast cancer: Protective role of MMP8 against lymph node metastasis. BMC Cancer 8 (2008) 77