Activation of mitogen-activated protein kinases is involved in the induction of interferon β gene in macrophages infected with Orientia tsutsugamushi

Microbiology and Immunology

Volumn 53, Issue 2, 2009, Pages 123-129

  Koo, Jung Eun ^a   Yun, Ji Hyun ^a,b   Lee, Keun Hwa ^a   Hyun, Jin Won ^a   Kang, Hee Kyoung ^a   Jang, Won Jong ^c   Park, Kyung Hee ^c   Koh, Young Sang ^a  

^a Jeju National University

^b Jeju Bio Industry Center   (South Korea)

^c Konkuk University School of Medicine   (South Korea)

Author keywords

Chemokine; Interferon ; Mitogen activated protein kinase; Orientia tsutsugamushi

Indexed keywords

BETA INTERFERON; CHEMOKINE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; CYTOCHALASIN D; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION REGULATION; GENE INDUCTION; IFN BETA GENE; INTERFERON INDUCTION; INTERNALIZATION; MACROPHAGE; MOUSE; NONHUMAN; ORIENTIA TSUTSUGAMUSHI; ANIMAL; CELL LINE; DRUG EFFECT; GENETICS; HEAT; METABOLISM; MICROBIOLOGY; PATHOGENICITY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME;

ORIENTIA; ORIENTIA TSUTSUGAMUSHI;

ANIMALS; CELL LINE; CYTOCHALASIN D; GENE EXPRESSION REGULATION; HOT TEMPERATURE; INTERFERON-BETA; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; ORIENTIA TSUTSUGAMUSHI; PHOSPHORYLATION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 64049098363     PISSN: 03855600     EISSN: 13480421     Source Type: Journal    
DOI: 10.1111/j.1348-0421.2008.00098.x     Document Type: Article

References (21)

1. ChiW.C., Huang J.J., Sung J.M., Lan R.R., KoW.C., Chen F.F. (1997) Scrub typhus associated with multiorgan failure: a case report. Scand J Infect Dis 29: 634-5.
2. Rikihisa Y., Ito S. (1979) Intracellular localization of Rickettsia tsutsugamushi in polymorphonuclear leukocytes. J ExpMed 150: 703-8.
3. Jerrells T.R., Osterman J.V. (1981) Host defenses in experimental scrub typhus: inflammatory response of congenic C3H mice differing at the Ric gene. Infect Immun 31: 1014-22.
4. Ng F.K., Oaks S.C. Jr., Lee M., Groves M.G., Lewis G.E. Jr. (1985) A scanning and transmission electron microscopic examination of Rickettsia tsutsugamushi-infected human endothelial, MRC-5, and L-929 cells. Jpn J Med Sci Biol 38: 125-39.
5. Chu H., Lee J.H., Han S.H., Kim S.Y., Cho N.H., Kim I.S. et al. (2006) Exploitation of the endocytic pathway by Orientia tsutsugamushi in nonprofessional phagocytes. Infect Immun 74: 4246-53.
6. Burnett J.W. (1980) Rickettsioses: a review for the dermatologist. J Am Acad Dermatol 2: 359-73.
7. Baggiolini M., Dewald B., Moser B. (1994) Interleukin-8 and related chemotactic cytokines-CXC and CC chemokines. Adv Immunol 55: 97-179.
8. Cho N.H., Seong S.Y., Huh M.S., Han T.H., Koh Y.S., Choi M.S. et al. (2000) Expression of chemokine genes in murine macrophage infected with Orientia tsutsugamushi. Infect Immun 68: 594-602.
9. Koh Y.S. (2001) Expression of chemokine and tumor necrosis factor alpha genes in murine peritoneal macrophages infected with Orientia tsutsugamushi. J Microbiol 39: 186-94.
10. Koh Y.S., Yun J.H., Seong S.Y., Choi M.S., Kim I.S. (2004) Chemokine and cytokine production during Orientia tsutsugamushi infection in mice. Microb Pathog 36: 51-7.
11. Yun J.H., Koh Y.S., Lee K.H., Hyun J.W., Choi Y.J., Jang W.J. et al. (2005) Chemokine and cytokine production in susceptible C3H/HeN mice and resistance BALB/c mice during Orientia tsutsugamushi infection. Microbiol Immunol 49: 551-7.
12. Roux P.P., Blenis J. (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68: 320-44.
13. Honda K., Taniguchi T. (2006) IRFs: master regulators of signalling by toll-like receptors and cytosolic pattern-recognition receptors. Nat Rev Immunol 6: 644-58.
14. Panne D., Maniatis T., Harrison S.C. (2004) Crystal structure of ATF-2/c-Jun and IRF-3 bound to the interferon-beta enhancer. EMBO J 23: 4384-93.
15. Dudley D.T., Pang L., Decker S.T., Bridges A.T., Saltiel A.R. (1995) A synthetic inhibitor of the mitogen activated protein kinase cascade. Proc Natl Acad Sci USA 92: 7686-9.
16. Lee J.C., Laydon J.T., McDonnell P.C., Gallagher T.F., Kumar S., Green D. et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372: 739-46.
17. Navarro L., David M. (1999) p38-dependent activation of interferon regulatory factor 3 by lipopolysaccharide. J Biol Chem 274: 35 535-8.
18. Saccani S., Pantano S., Natoli G. (2002) p38-dependent marking of inflammatory genes for increased NF-kappa B recruitment. Nat Immunol 3: 69-75.
19. Platanias L.C. (2005) Mechanisms of type I and type II interferon-mediated signalling. Nat Rev Immunol 5: 375-86.
20. Wang F., Ma Y., Barrett J.W., Gao X., Loh J., Barton E. et al. (2004) Disruption of Erk-depe1ndent type I interferon induction breaks the myxoma virus species barrier. Nat Immunol 5: 1266-74.11
21. David M., Petricoin E. 3rd, Benjamin C., Pine R., Weber M.J., Larner A.C. (1995) Requirement for MAP kinase (ERK2) activity in interferon α- and interferon β stimulated gene expression through STAT proteins. Science 269: 1721-3.