Coronary blood flow responses to physiological stress in humans

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 296, Issue 3, 2009, Pages

  Momen, Afsana ^a   Mascarenhas, Vernon ^a   Gahremanpour, Amir ^a   Gao, Zhaohui ^a   Moradkhan, Raman ^a   Kunselman, Allen ^b   Boehmer, John P ^a   Sinoway, Lawrence I ^a,b   Leuenberger, Urs A ^a  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

Autonomic nervous system; Exercise; Hypoxia; Oxygen

Indexed keywords

ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD FLOW VELOCITY; BLOOD PRESSURE; BLOOD PRESSURE MEASUREMENT; CARDIOVASCULAR PARAMETERS; COLD PRESSOR TEST; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY CONSTRICTION; CORONARY ARTERY DILATATION; FEMALE; HAND GRIP; HEART BEAT; HEART RATE VARIABILITY; HEART VOLUME; HUMAN; HUMAN EXPERIMENT; HYPERCAPNIA; HYPEROXIA; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; MUSCLE CONTRACTION; NORMAL HUMAN; PHYSIOLOGICAL STRESS; PRIORITY JOURNAL; SYMPATHETIC TONE; VOLUNTARY MOVEMENT; ADRENERGIC SYSTEM; ANOXIA; COLD; CORONARY BLOOD VESSEL; DOPPLER ECHOCARDIOGRAPHY; ECHOGRAPHY; HAND STRENGTH; HEART RATE; INNERVATION; LOWER BODY NEGATIVE PRESSURE; PATHOPHYSIOLOGY; VASOCONSTRICTION; VASODILATATION;

ADULT; ANOXIA; BLOOD FLOW VELOCITY; BLOOD PRESSURE; COLD TEMPERATURE; CORONARY CIRCULATION; CORONARY VESSELS; ECHOCARDIOGRAPHY, DOPPLER; FEMALE; HAND STRENGTH; HEART RATE; HUMANS; HYPERCAPNIA; HYPEROXIA; LOWER BODY NEGATIVE PRESSURE; MALE; MUSCLE CONTRACTION; STRESS, PHYSIOLOGICAL; SYMPATHETIC NERVOUS SYSTEM; VASOCONSTRICTION; VASODILATION;

EID: 64049096602     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01075.2007     Document Type: Article

References (69)

1. Aung-Din R, Mitchell JH, Longhurst JC. Reflex α-adrenergic coronary vasoconstriction during hindlimb static exercise in dogs. Circ Res 48: 502-509, 1981.
2. Baily RG, Sinoway LI. Insight into human baroreceptor function using multiple indices of neural activity. Heart Fail 6: 33-41, 1990.
3. Baumgart D, Ehring T, Kowallik P, Guth BD, Krajcar M, Heusch G. Impact of alpha-adrenergic coronary vasoconstriction on the transmural myocardial blood flow distribution during humoral and neuronal adrenergic activation. Circ Res 73: 869-886, 1993.
4. Bengel FM, Ueberfuhr P, Ziegler SI, Nekolla S, Reichart B, Schwaiger M. Serial assessment of sympathetic reinnervation after orthotopic heart transplantation. A longitudinal study using PET and C-11 hydroxyephedrine. Circulation 99: 1866-1871, 1999.
5. Berne RM. Cardiac nucleotides in hypoxia: possible role in regulation of coronary blood flow. Am J Physiol 204: 317-322, 1963.
6. Broten TP, Romson JL, Fullerton DA, Van Winkle DM, Feigl EO. Synergistic action of myocardial oxygen and carbon dioxide in controlling coronary blood flow. Circ Res 68: 531-542, 1991.
7. Caiati C, Montaldo C, Zedda N, Montisci R, Ruscazio M, Lai G, Cadeddu M, Meloni L, Iliceto S. Validation of a new noninvasive method (contrast-enhanced transthoracic second harmonic echo Doppler) for the evaluation of coronary flow reserve: comparison with intracoronary Doppler flow wire. J Am Coll Cardiol 34: 1193-1200, 1999.
8. Chilian WM. Coronary microcirculation in health and disease. Summary of an NHLBI workshop. Circulation 95: 522-528, 1997.
9. Chilian WM. Functional distribution of alpha 1- and alpha 2-adrenergic receptors in the coronary microcirculation. Circulation 84: 2108-2122, 1991.
10. Chilian WM, Harrison DG, Haws CW, Snyder WD, Marcus ML. Adrenergic coronary tone during submaximal exercise in the dog is produced by circulating catecholamines. Evidence for adrenergic denervation supersensitivity in the myocardium but not in coronary vessels. Circ Res 58: 68 -82, 1986.
11. De Marco T, Dae M, Yuen-Green MS, Kumar S, Sudhir K, Keith F, Amidon TM, Rifkin C, Klinski C, Lau D, Botvinick EH, Chatterjee K. Iodine-123 metaiodobenzylguanidine scintigraphic assessment of the transplanted human heart: evidence for late reinnervation. J Am Coll Cardiol 25: 927-931, 1995.
12. Di Carli MF, Tobes MC, Mangner T, Levine AB, Muzik O, Chakroborty P, Levine TB. Effects of cardiac sympathetic innervation on coronary blood flow. N Engl J Med 336: 1208-1215, 1997.
13. Doucette JW, Corl PD, Payne HM, Flynn AE, Goto M, Nassi M, Segal J. Validation of a Doppler guide wire for intravascular measurement of coronary artery flow velocity. Circulation 85: 1899-1911, 1992.
14. Duncker DJ, Merkus D. Acute adaptations of the coronary circulation to exercise. Cell Biochem Biophys 43: 17-35, 2005.
15. Feigl EO. Coronary physiology. Physiol Rev 63: 1-205, 1983.
16. Friedman DB, Jensen FB, Mitchell JH, Secher NH. Heart rate and arterial blood pressure at the onset of static exercise in man with complete neural blockade. J Physiol 423: 543-550, 1990.
17. Furlan R, Jacob G, Palazzolo L, Rimoldi A, Diedrich A, Harris PA, Porta A, Malliani A, Mosqueda-Garcia R, Robertson D. Sequential modulation of cardiac autonomic control induced by cardiopulmonary and arterial baroreflex mechanisms. Circulation 104: 2932-2937, 2001.
18. Gurevicius J, Salem MR, Metwally AA, Silver JM, Crystal GJ. Contribution of nitric oxide to coronary vasodilation during hypercapnic acidosis. Am J Physiol Heart Circ Physiol 268: H39-H47, 1995.
19. Heintz A, Koch T, Deussen A. Intact nitric oxide production is obligatory for the sustained flow response during hypercapnic acidosis in guinea pig heart. Cardiovasc Res 66: 55-63, 2005.
20. Herr MD, Imadojemu V, Kunselman AR, Sinoway LI. Characteristics of the muscle mechanoreflex during quadriceps contractions in humans. J Appl Physiol 86: 767-772, 1999.
21. Herrmann SC, Feigl EO. Adrenergic blockade blunts adenosine concentration and coronary vasodilation during hypoxia. Circ Res 70: 1203-1216, 1992.
22. Hirata K, Amudha K, Elina R, Hozumi T, Yoshikawa J, Homma S, Lang CC. Measurement of coronary vasomotor function: getting to the heart of the matter in cardiovascular research. Clin Sci (Lond) 107: 449-460, 2004.
23. Hozumi T, Yoshida K, Akasaka T, Asami Y, Ogata Y, Takagi T, Kaji S, Kawamoto T, Ueda Y, Morioka S. Noninvasive assessment of coronary flow velocity and coronary flow velocity reserve in the left anterior descending coronary artery by Doppler echocardiography: comparison with invasive technique. J Am Coll Cardiol 32: 1251-1259, 1998.
24. Huang AH, Feigl EO. Adrenergic coronary vasoconstriction helps maintain uniform transmural blood flow distribution during exercise. Circ Res 62: 286-298, 1988.
25. Ishibashi T, Ichihara K, Abiko Y. Difference in the time course between increases in coronary flow and in effluent adenosine concentration during anoxia in the perfused rat heart. Jpn Circ J 49: 1090-1098, 1985.
26. Jones CJ, DeFily DV, Patterson JL, Chilian WM. Endothelium-dependent relaxation competes with alpha 1- and alpha 2-adrenergic constriction in the canine epicardial coronary microcirculation. Circulation 87: 1264-1274, 1993.
27. Kaye DM, Esler M, Kingwell B, McPherson G, Esmore D, Jennings G. Functional and neurochemical evidence for partial cardiac sympathetic reinnervation after cardiac transplantation in humans. Circulation 88: 1110-1118, 1993.
28. Khan MH, Sinoway LI, MacLean DA. Effects of graded LBNP on MSNA and interstitial norepinephrine. Am J Physiol Heart Circ Physiol 283: H2038-H2044, 2002.
29. Kuo L, Davis MJ, Chilian WM. Myogenic activity in isolated subepi- cardial and subendocardial coronary arterioles. Am J Physiol Heart Circ Physiol 255: H1558-H1562, 1988.
30. Lee PJ, Choi AM. Pathways of cell signaling in hyperoxia. Free Radic Biol Med 35: 341-350, 2003.
31. Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF Jr, Vita JA. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation 93: 1107-1113, 1996.
32. Longhurst JC. Coronary arteriolar vasoconstriction in myocardial ischaemia: reflexes, sympathetic nervous system, catecholamines. Eur Heart J 11, Suppl B: 43-52, 1990.
33. Mark AL, Victor RG, Nerhed C, Wallin BG. Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans. Circ Res 57: 461-469, 1985.
34. Martinez RR, Setty S, Zong P, Tune JD, Downey HF. Nitric oxide contributes to right coronary vasodilation during systemic hypoxia. Am J Physiol Heart Circ Physiol 288: H1139-H1146, 2005.
35. Matsukawa K, Wall PT, Wilson LB, Mitchell JH. Reflex stimulation of cardiac sympathetic nerve activity during static muscle contraction in cats. Am J Physiol Heart Circ Physiol 267: H821-H827, 1994.
36. McNulty PH, Robertson BJ, Tulli MA, Hess J, Harach LA, Scott S, Sinoway LI. Effect of hyperoxia and vitamin C on coronary blood flow in patients with ischemic heart disease. J Appl Physiol 102: 2040 -2045, 2007.
37. Meeder JG, Peels HO, Blanksma PK, Tan ES, Pruim J, van der Wall EE, Vaalburg W, Lie KI. Comparison between positron emission to mography myocardial perfusion imaging and intracoronary Doppler flow velocity measurements at rest and during cold pressor testing in angiographically normal coronary arteries in patients with one-vessel coronary artery disease. Am J Cardiol 78: 526-531, 1996.
38. Meimoun P, Sayah S, Tcheuffa JC, Benali T, Luycx-Bore A, Levy F, Tribouilloy C. Transthoracic coronary flow velocity reserve assessment: comparison between adenosine and dobutamine. J Am Soc Echocardiogr 19: 1220-1228, 2006.
39. Miller FJ Jr, Dellsperger KC, Gutterman DD. Myogenic constriction of human coronary arterioles. Am J Physiol Heart Circ Physiol 273: H257-H264, 1997.
40. Momen A, Gahremanpour A, Mansoor A, Kunselman A, Blaha C, Pae W, Leuenberger UA, Sinoway LI. Vasoconstriction seen in coronary bypass grafts during handgrip in humans. J Appl Physiol 102:735-739, 2007.
41. Momen A, Thomas K, Blaha C, Gahremanpour A, Mansoor A, Leuenberger U, Sinoway L. Renal vasoconstrictor responses to static exercise during orthostatic stress in humans: effects of the muscle mechano- and the baroreflexes. J Physiol 573: 819-825, 2006.
42. Mudge GH Jr, Grossman W, Mills RM Jr, Lesch M, Braunwald E. Reflex increase in coronary vascular resistance in patients with ischemic heart disease. N Engl J Med 295: 1333-1337, 1976.
43. Nabel EG, Ganz P, Gordon JB, Alexander RW, Selwyn AP. Dilation of normal and constriction of atherosclerotic coronary arteries caused by the cold pressor test. Circulation 77: 43-52, 1988.
44. Park KH, Rubin LE, Gross SS, Levi R. Nitric oxide is a mediator of hypoxic coronary vasodilatation. Relation to adenosine and cyclooxyge- nase-derived metabolites. Circ Res 71: 992-1001, 1992.
45. Powell JR, Feigl EO. Carotid sinus reflex coronary vasoconstriction during controlled myocardial oxygen metabolism in the dog. Circ Res 44: 44-51, 1979.
46. Quinones MA, Mokotoff DM, Nouri S, Winters WL Jr, Miller RR. Noninvasive quantification of left ventricular wall stress. Validation of method and application to assessment of chronic pressure overload. Am J Cardiol 45: 782-790, 1980.
47. Ray CA, Monahan KD. Sympathetic vascular transduction is augmented in young normotensive blacks. J Appl Physiol 92: 651-656, 2002.
48. Rubanyi GM, Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol Heart Circ Physiol 250: H822-H827, 1986.
49. Schindler TH, Hornig B, Buser PT, Olschewski M, Magosaki N, Pfisterer M, Nitzsche EU, Solzbach U, Just H. Prognostic value of abnormal vasoreactivity of epicardial coronary arteries to sympathetic stimulation in patients with normal coronary angiograms. Arterioscler Thromb Vasc Biol 23: 495-501, 2003.
50. Sheriff DD, Augustyniak RA, O'Leary DS. Muscle chemoreflex-in- duced increases in right atrial pressure. Am J Physiol Heart Circ Physiol 275: H767-H775, 1998.
51. Shoemaker JK, Hogeman CS, Khan M, Kimmerly D, Sinoway LI. Gender affects sympathetic and hemodynamic response to postural stress. Am J Physiol Heart Circ Physiol 281: H2028-H2035, 2001.
52. Sinoway LI, Rea RF, Mosher TJ, Smith MB, Mark AL. Hydrogen ion concentration is not the sole determinant of muscle metaboreceptor responses in humans. J Clin Invest 89: 1875-1884, 1992.
53. Taddei S, Virdis A, Ghiadoni L, Magagna A, Salvetti A. Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension. Circulation 97: 2222-2229, 1998.
54. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 97: 22-28, 1996.
55. Trimarco B, Vigorito C, Cuocolo A, Ricciardelli B, De Luca N, Volpe M, Lembo G, Condorelli M. Reflex control of coronary vascular tone by cardiopulmonary receptors in humans. J Am Coll Cardiol 11: 944 -952, 1988.
56. Tune JD, Richmond KN, Gorman MW, Feigl EO. Control of coronary blood flow during exercise. Exp Biol Med (Maywood) 227: 238-250, 2002.
57. Tzou WS, Korcarz CE, Aeschlimann SE, Morgan BJ, Skatrud JB, Stein JH. Coronary flow velocity changes in response to hypercapnia: assessment by transthoracic Doppler echocardiography. J Am Soc Echocardiogr 20: 421-426, 2007.
58. Victor RG, Leimbach WN Jr, Seals DR, Wallin BG, and Mark AL. Effects of the cold pressor test on muscle sympathetic nerve activity in humans. Hypertension 9: 429 -436, 1987.
59. Victor RG, Secher NH, Lyson T, Mitchell JH. Central command increases muscle sympathetic nerve activity during intense intermittent isometric exercise in humans. Circ Res 76: 127-131, 1995.
60. Voci P, Testa G, Plaustro G, Caretta Q. Coronary Doppler intensity changes during handgrip: a new method to detect coronary vasomotor tone in coronary artery disease. J Am Coll Cardiol 34: 428 -434, 1999.
61. Volpe M, Trimarco B, Cuocolo A, Vigorito C, Cicala M, Ricciardelli B, Condorelli M. Carotid sinus reflex control of coronary blood flow in human subjects. J Am Coll Cardiol 5: 1312-1318, 1985.
62. Waldrop TG, Eldridge FL, Iwamoto GA, Mitchell JH. Central neural control of respiration and circulation during exercise. In: Handbook of Physiology. Exercise: Regulation and Integration of Multiple Systems. Bethesda, MD: Am. Physiol. Soc., 1996, sect. 12, chapt. 9, p. 333-380.
63. Weicker H. Determination of free and sulfoconjugated catecholamines in plasma and urine by high-performance liquid chromatography. Int J Sports Med 9: S68 -S74, 1988.
64. Wilson RF, Christensen BV, Olivari MT, Simon A, White CW, Laxson DD. Evidence for structural sympathetic reinnervation after orthotopic cardiac transplantation in humans. Circulation 83: 1210-1220, 1991.
65. Wilson RF, Wyche K, Christensen BV, Zimmer S, Laxson DD. Effects of adenosine on human coronary arterial circulation. Circulation 82: 1595-1606, 1990.
66. Wilson TE, Tollund C, Yoshiga CC, Dawson EA, Nissen P, Secher NH, Crandall CG. Effects of heat and cold stress on central vascular pressure relationships during orthostasis in humans. J Physiol 585: 279 -285, 2007.
67. Zeiher AM, Drexler H. Coronary hemodynamic determinants of epicardial artery vasomotor responses during sympathetic stimulation in humans. Basic Res Cardiol 86, Suppl 2: 203-213, 1991.
68. Zeiher AM, Drexler H, Wollschlaeger H, Saurbier B, Just H. Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium. J Am Coll Cardiol 14: 1181-1190, 1989.
69. Zoller RP, Mark AL, Abboud FM, Schmid PG, Heistad DD. The role of low pressure baroreceptors in reflex vasoconstrictor responses in man. J Clin Invest 51: 2967-2972, 1972.