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Volumn 63, Issue 6, 2009, Pages 1065-1071

Phase i study of cetuximab, erlotinib, and bevacizumab in patients with advanced solid tumors

Author keywords

Epidermal growth factor receptor; Renal cell carcinoma; Vascular endothelial growth factor

Indexed keywords

BEVACIZUMAB; CETUXIMAB; ERLOTINIB;

EID: 63949084255     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0811-x     Document Type: Article
Times cited : (15)

References (36)
  • 1
    • 1542329005 scopus 로고    scopus 로고
    • The erbB family: Targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors
    • EK Rowinsky 2004 The erbB family: targets for therapeutic development against cancer and therapeutic strategies using monoclonal antibodies and tyrosine kinase inhibitors Annu Rev Med 55 433 457
    • (2004) Annu Rev Med , vol.55 , pp. 433-457
    • Rowinsky, E.K.1
  • 2
    • 23844491524 scopus 로고    scopus 로고
    • Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations
    • T Mukohara JA Engelman NH Hanna 2005 Differential effects of gefitinib and cetuximab on non-small-cell lung cancers bearing epidermal growth factor receptor mutations J Natl Cancer Inst 97 1185 1194
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1185-1194
    • Mukohara, T.1    Engelman, J.A.2    Hanna, N.H.3
  • 3
    • 33747855481 scopus 로고    scopus 로고
    • Comparing antibody and small-molecule therapies for cancer
    • K Imai A Takaoka 2006 Comparing antibody and small-molecule therapies for cancer Nat Rev Cancer 6 714 727
    • (2006) Nat Rev Cancer , vol.6 , pp. 714-727
    • Imai, K.1    Takaoka, A.2
  • 4
    • 3442891161 scopus 로고    scopus 로고
    • Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): Combining anti-EGFR antibody with tyrosine kinase inhibitor
    • S Huang EA Armstrong S Benavente 2004 Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor Cancer Res 64 5355 5362
    • (2004) Cancer Res , vol.64 , pp. 5355-5362
    • Huang, S.1    Armstrong, E.A.2    Benavente, S.3
  • 5
    • 5144229336 scopus 로고    scopus 로고
    • Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): Superiority over single-agent receptor targeting
    • P Matar F Rojo R Cassia 2004 Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting Clin Cancer Res 10 6487 6501
    • (2004) Clin Cancer Res , vol.10 , pp. 6487-6501
    • Matar, P.1    Rojo, F.2    Cassia, R.3
  • 6
    • 17144415942 scopus 로고    scopus 로고
    • Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents
    • A Jimeno B Rubio-Viqueira ML Amador 2005 Epidermal growth factor receptor dynamics influences response to epidermal growth factor receptor targeted agents Cancer Res 65 3003 3010
    • (2005) Cancer Res , vol.65 , pp. 3003-3010
    • Jimeno, A.1    Rubio-Viqueira, B.2    Amador, M.L.3
  • 7
    • 0032972944 scopus 로고    scopus 로고
    • Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
    • P Perrotte T Matsumoto K Inoue 1999 Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice Clin Cancer Res 5 257 265
    • (1999) Clin Cancer Res , vol.5 , pp. 257-265
    • Perrotte, P.1    Matsumoto, T.2    Inoue, K.3
  • 8
    • 0034212763 scopus 로고    scopus 로고
    • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
    • CJ Bruns CC Solorzano MT Harbison 2000 Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma Cancer Res 60 2926 2935
    • (2000) Cancer Res , vol.60 , pp. 2926-2935
    • Bruns, C.J.1    Solorzano, C.C.2    Harbison, M.T.3
  • 9
    • 0034896362 scopus 로고    scopus 로고
    • Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
    • F Ciardiello R Caputo R Bianco 2001 Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor Clin Cancer Res 7 1459 1465
    • (2001) Clin Cancer Res , vol.7 , pp. 1459-1465
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3
  • 10
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • J Mendelsohn J Baselga 2003 Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer J Clin Oncol 21 2787 2799
    • (2003) J Clin Oncol , vol.21 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 11
    • 0036252329 scopus 로고    scopus 로고
    • Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model
    • YD Jung PF Mansfield M Akagi 2002 Effects of combination anti-vascular endothelial growth factor receptor and anti-epidermal growth factor receptor therapies on the growth of gastric cancer in a nude mouse model Eur J Cancer 38 1133 1140
    • (2002) Eur J Cancer , vol.38 , pp. 1133-1140
    • Jung, Y.D.1    Mansfield, P.F.2    Akagi, M.3
  • 12
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • F Ciardiello R Bianco V Damiano 2000 Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells Clin Cancer Res 6 3739 3747
    • (2000) Clin Cancer Res , vol.6 , pp. 3739-3747
    • Ciardiello, F.1    Bianco, R.2    Damiano, V.3
  • 13
    • 17944370631 scopus 로고    scopus 로고
    • Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors
    • RM Shaheen SA Ahmad W Liu 2001 Inhibited growth of colon cancer carcinomatosis by antibodies to vascular endothelial and epidermal growth factor receptors Br J Cancer 85 584 589
    • (2001) Br J Cancer , vol.85 , pp. 584-589
    • Shaheen, R.M.1    Ahmad, S.A.2    Liu, W.3
  • 14
    • 23844555670 scopus 로고    scopus 로고
    • Cetuximab therapy and symptomatic hypomagnesemia
    • D Schrag KY Chung C Flombaum 2005 Cetuximab therapy and symptomatic hypomagnesemia J Natl Cancer Inst 97 1221 1224
    • (2005) J Natl Cancer Inst , vol.97 , pp. 1221-1224
    • Schrag, D.1    Chung, K.Y.2    Flombaum, C.3
  • 15
    • 34247224987 scopus 로고    scopus 로고
    • Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: A prospective study
    • S Tejpar H Piessevaux K Claes 2007 Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study Lancet Oncol 8 387 394
    • (2007) Lancet Oncol , vol.8 , pp. 387-394
    • Tejpar, S.1    Piessevaux, H.2    Claes, K.3
  • 16
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada
    • P Therasse SG Arbuck EA Eisenhauer 2000 New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 92 205 216
    • (2000) J Natl Cancer Inst , vol.92 , pp. 205-216
    • Therasse, P.1    Arbuck, S.G.2    Eisenhauer, E.A.3
  • 17
    • 0142119289 scopus 로고    scopus 로고
    • Epidermal growth factor receptor in non-small-cell lung carcinomas: Correlation between gene copy number and protein expression and impact on prognosis
    • FR Hirsch M Varella-Garcia PA Bunn Jr 2003 Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis J Clin Oncol 21 3798 3807
    • (2003) J Clin Oncol , vol.21 , pp. 3798-3807
    • Hirsch, F.R.1    Varella-Garcia, M.2    Bunn Jr, P.A.3
  • 18
    • 33746622984 scopus 로고    scopus 로고
    • Strategies for optimizing combinations of molecularly targeted anticancer agents
    • JE Dancey HX Chen 2006 Strategies for optimizing combinations of molecularly targeted anticancer agents Nat Rev Drug Discov 5 649 659
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 649-659
    • Dancey, J.E.1    Chen, H.X.2
  • 19
    • 33749237209 scopus 로고    scopus 로고
    • A phase i pharmacokinetic (PK) and molecular pharmacodynamic (PD) study of the combination of two anti-EGFR therapies, the monoclonal antibody (MAb) cetuximab (C) and the tyrosine kinase inhibitor (TKI) gefitinib (G), in patients (pts) with advanced colorectal (CRC), head and neck (HNC) and non-small cell lung cancer (NSCLC)
    • J Baselga P Schoffski F Rojo 2006 A phase I pharmacokinetic (PK) and molecular pharmacodynamic (PD) study of the combination of two anti-EGFR therapies, the monoclonal antibody (MAb) cetuximab (C) and the tyrosine kinase inhibitor (TKI) gefitinib (G), in patients (pts) with advanced colorectal (CRC), head and neck (HNC) and non-small cell lung cancer (NSCLC) J Clin Oncol (Meet Abstr) 24 3006
    • (2006) J Clin Oncol (Meet Abstr) , vol.24 , pp. 3006
    • Baselga, J.1    Schoffski, P.2    Rojo, F.3
  • 20
    • 33846688823 scopus 로고    scopus 로고
    • Total blockade of the epidermal growth factor receptor with the combination of cetuximab and gefitinib: A phase i study for patients with recurrent non-small cell lung cancer (NSCLC)
    • CL Naret S Ramalingam L Beattie 2006 Total blockade of the epidermal growth factor receptor with the combination of cetuximab and gefitinib: a phase I study for patients with recurrent non-small cell lung cancer (NSCLC) J Clin Oncol (Meet Abstr) 24 17045
    • (2006) J Clin Oncol (Meet Abstr) , vol.24 , pp. 17045
    • Naret, C.L.1    Ramalingam, S.2    Beattie, L.3
  • 21
    • 63949087998 scopus 로고    scopus 로고
    • Dual inhibition of the epidermal growth factor receptor (EGFR) pathway with the combination of cetuximab and erlotinib: A phase i study in patients with advanced solid malignancies
    • abstract A147
    • Guarino MJ, Schneider CJ, Hosford MA et al (2007) Dual inhibition of the epidermal growth factor receptor (EGFR) pathway with the combination of cetuximab and erlotinib: a phase I study in patients with advanced solid malignancies. Proc AACR-NCI-EORTC Mol Targets Cancer Ther 2007; abstract A147
    • (2007) Proc AACR-NCI-EORTC Mol Targets Cancer Ther 2007
    • Guarino, M.J.1    Schneider, C.J.2    Hosford, M.A.3
  • 22
    • 23844527898 scopus 로고    scopus 로고
    • A phase i study of erlotinib and bevacizumab for recurrent or metastatic squamous cell carcinoma of the head and neck (HNC)
    • EE Vokes EEW Cohen AM Mauer 2005 A phase I study of erlotinib and bevacizumab for recurrent or metastatic squamous cell carcinoma of the head and neck (HNC) J Clin Oncol (Meet Abstr) 23 5504
    • (2005) J Clin Oncol (Meet Abstr) , vol.23 , pp. 5504
    • Vokes, E.E.1    Cohen, E.E.W.2    Mauer, A.M.3
  • 23
    • 20244381389 scopus 로고    scopus 로고
    • Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer
    • RS Herbst DH Johnson E Mininberg 2005 Phase I/II trial evaluating the anti-vascular endothelial growth factor monoclonal antibody bevacizumab in combination with the HER-1/epidermal growth factor receptor tyrosine kinase inhibitor erlotinib for patients with recurrent non-small-cell lung cancer J Clin Oncol 23 2544 2555
    • (2005) J Clin Oncol , vol.23 , pp. 2544-2555
    • Herbst, R.S.1    Johnson, D.H.2    Mininberg, E.3
  • 24
    • 30944452354 scopus 로고    scopus 로고
    • Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib
    • JD Hainsworth JA Sosman DR Spigel 2005 Treatment of metastatic renal cell carcinoma with a combination of bevacizumab and erlotinib J Clin Oncol 23 7889 7896
    • (2005) J Clin Oncol , vol.23 , pp. 7889-7896
    • Hainsworth, J.D.1    Sosman, J.A.2    Spigel, D.R.3
  • 25
    • 33750625979 scopus 로고    scopus 로고
    • A phase II, multicenter, randomized clinical trial to evaluate the efficacy and safety of bevacizumab in combination with either chemotherapy (docetaxel or pemetrexed) or erlotinib hydrochloride compared with chemotherapy alone for treatment of recurrent or refractory non-small cell lung cancer
    • L Fehrenbacher V O'Neill CP Belani 2006 A phase II, multicenter, randomized clinical trial to evaluate the efficacy and safety of bevacizumab in combination with either chemotherapy (docetaxel or pemetrexed) or erlotinib hydrochloride compared with chemotherapy alone for treatment of recurrent or refractory non-small cell lung cancer J Clin Oncol (Meet Abstr) 24 7062
    • (2006) J Clin Oncol (Meet Abstr) , vol.24 , pp. 7062
    • Fehrenbacher, L.1    O'Neill, V.2    Belani, C.P.3
  • 26
    • 33845287895 scopus 로고    scopus 로고
    • Bevacizumab (B) plus erlotinib (E) for patients (pts) with recurrent ovarian (OC) and fallopian tube (FT) cancer: Preliminary results of a multi-center phase II trial
    • G Friberg AM Oza RJ Morgan 2006 Bevacizumab (B) plus erlotinib (E) for patients (pts) with recurrent ovarian (OC) and fallopian tube (FT) cancer: preliminary results of a multi-center phase II trial J Clin Oncol (Meet Abstr) 24 5018
    • (2006) J Clin Oncol (Meet Abstr) , vol.24 , pp. 5018
    • Friberg, G.1    Oza, A.M.2    Morgan, R.J.3
  • 27
    • 7944228610 scopus 로고    scopus 로고
    • Phase II trial of erlotinib (OSI-774), an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, and bevacizumab, a recombinant humanized monoclonal antibody to vascular endothelial growth factor (VEGF), in patients (pts) with metastatic breast cancer (MBC)
    • M Dickler H Rugo J Caravelli 2004 Phase II trial of erlotinib (OSI-774), an epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor, and bevacizumab, a recombinant humanized monoclonal antibody to vascular endothelial growth factor (VEGF), in patients (pts) with metastatic breast cancer (MBC) J Clin Oncol (Meet Abstr) 22 2001
    • (2004) J Clin Oncol (Meet Abstr) , vol.22 , pp. 2001
    • Dickler, M.1    Rugo, H.2    Caravelli, J.3
  • 28
    • 34248995210 scopus 로고    scopus 로고
    • Phase II trial of bevacizumab and erlotinib in carcinomas of unknown primary site: The Minnie Pearl Cancer Research Network
    • JD Hainsworth DR Spigel C Farley 2007 Phase II trial of bevacizumab and erlotinib in carcinomas of unknown primary site: the Minnie Pearl Cancer Research Network J Clin Oncol 25 1747 1752
    • (2007) J Clin Oncol , vol.25 , pp. 1747-1752
    • Hainsworth, J.D.1    Spigel, D.R.2    Farley, C.3
  • 29
    • 35648938219 scopus 로고    scopus 로고
    • Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer
    • RM Bukowski FF Kabbinavar RA Figlin 2007 Randomized phase II study of erlotinib combined with bevacizumab compared with bevacizumab alone in metastatic renal cell cancer J Clin Oncol 25 4536 4541
    • (2007) J Clin Oncol , vol.25 , pp. 4536-4541
    • Bukowski, R.M.1    Kabbinavar, F.F.2    Figlin, R.A.3
  • 30
    • 35648941728 scopus 로고    scopus 로고
    • Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: The BOND-2 study
    • LB Saltz HJ Lenz HL Kindler 2007 Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study J Clin Oncol 25 4557 4561
    • (2007) J Clin Oncol , vol.25 , pp. 4557-4561
    • Saltz, L.B.1    Lenz, H.J.2    Kindler, H.L.3
  • 31
    • 34248344725 scopus 로고    scopus 로고
    • Clinical utility of epidermal growth factor receptor expression for selecting patients with advanced non-small cell lung cancer for treatment with erlotinib
    • GM Clark DM Zborowski JL Culbertson 2006 Clinical utility of epidermal growth factor receptor expression for selecting patients with advanced non-small cell lung cancer for treatment with erlotinib J Thorac Oncol 1 837 846
    • (2006) J Thorac Oncol , vol.1 , pp. 837-846
    • Clark, G.M.1    Zborowski, D.M.2    Culbertson, J.L.3
  • 32
    • 2342624080 scopus 로고    scopus 로고
    • EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
    • JG Paez PA Janne JC Lee 2004 EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy Science 304 1497 1500
    • (2004) Science , vol.304 , pp. 1497-1500
    • Paez, J.G.1    Janne, P.A.2    Lee, J.C.3
  • 33
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • TJ Lynch DW Bell R Sordella 2004 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib N Engl J Med 350 2129 2139
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 34
    • 4444344330 scopus 로고    scopus 로고
    • EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib
    • W Pao V Miller M Zakowski 2004 EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib Proc Natl Acad Sci USA 101 13306 13311
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 13306-13311
    • Pao, W.1    Miller, V.2    Zakowski, M.3
  • 35
    • 33244473097 scopus 로고    scopus 로고
    • A phase III randomized, open-label, controlled trial of chemotherapy and bevacizumab with or without panitumumab in the first-line treatment of patients with metastatic colorectal cancer
    • Z Wainberg JR Hecht 2006 A phase III randomized, open-label, controlled trial of chemotherapy and bevacizumab with or without panitumumab in the first-line treatment of patients with metastatic colorectal cancer Clin Colorectal Cancer 5 363 367
    • (2006) Clin Colorectal Cancer , vol.5 , pp. 363-367
    • Wainberg, Z.1    Hecht, J.R.2
  • 36
    • 34948838898 scopus 로고    scopus 로고
    • Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer
    • JV Heymach BE Johnson D Prager 2007 Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer J Clin Oncol 25 4270 4277
    • (2007) J Clin Oncol , vol.25 , pp. 4270-4277
    • Heymach, J.V.1    Johnson, B.E.2    Prager, D.3


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