Assessment of vertebral fracture risk and therapeutic effects of alendronate in postmenopausal women using a quantitative computed tomography-based nonlinear finite element method

Osteoporosis International

Volumn 20, Issue 5, 2009, Pages 801-810

  Imai, K ^a,b   Ohnishi, I ^a   Matsumoto, T ^a   Yamamoto, S ^b   Nakamura, K ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Tokyo Metropolitan Institute of Gerontology   (Japan)

Author keywords

Alendronate; Bone mechanics; Finite element method; Fracture risk; Osteoporosis; Vertebral strength

Indexed keywords

ALENDRONIC ACID;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BODY WEIGHT; BONE DENSITY; BONE STRENGTH; BONE STRESS; CANCELLOUS BONE; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DRUG EFFECT; FEMALE; FINITE ELEMENT ANALYSIS; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SENSITIVITY AND SPECIFICITY; TREATMENT DURATION; UNSPECIFIED SIDE EFFECT; VERTEBRA FRACTURE;

AGED; AGED, 80 AND OVER; ALENDRONATE; ASIAN CONTINENTAL ANCESTRY GROUP; BONE DENSITY; BONE DENSITY CONSERVATION AGENTS; COMPRESSIVE STRENGTH; FEMALE; FINITE ELEMENT ANALYSIS; HUMANS; LUMBAR VERTEBRAE; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; POSTMENOPAUSE; PROSPECTIVE STUDIES; RADIOGRAPHIC IMAGE INTERPRETATION, COMPUTER-ASSISTED; RISK ASSESSMENT; SENSITIVITY AND SPECIFICITY; SPINAL FRACTURES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 63949083871     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-008-0750-8     Document Type: Article

References (42)

1. NIH Consensus Development Panel on Osteoporosis Prevention D, and Therapy 2001 Osteoporosis prevention, diagnosis, and therapy JAMA 285 785 795
2. SJ Edmondston KP Singer RE Day 1994 In-vitro relationships between vertebral body density, size and compressive strength in the elderly thoracolumbar spine Clin Biomech 9 180 186
3. XG Cheng PH Nicholson S Boonen 1997 Prediction of vertebral strength in vitro by spinal bone densitometry and calcaneal ultrasound J Bone Miner Res 12 1721 1728
4. SA Eriksson BO Isberg JU Lindgren 1989 Prediction of vertebral strength by dual photon absorptiometry and quantitative computed tomography Calcif Tissue Int 44 243 250
5. BS Myers KB Arbogast B Lobaugh 1994 Improved assessment of lumbar vertebral body strength using supine lateral dual-energy X-ray absorptiometry J Bone Miner Res 9 687 693
6. K Bjarnason C Hassager OL Svendsen 1996 Anteroposterior and lateral spinal DXA for the assessment of vertebral body strength: comparison with hip and forearm measurement Osteoporos Int 6 37 42
7. D Marshall O Johnell H Wedel 1996 Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures BMJ 312 1254 1259
8. DD Cody GJ Gross FJ Hou 1999 Femoral strength is better predicted by finite element models than QCT and DXA J Biomech 32 1013 1020
9. JH Keyak SA Rossi KA Jones 1998 Prediction of femoral fracture load using automated finite element modeling J Biomech 31 125 133
10. JH Keyak SA Rossi KA Jones 2001 Prediction of fracture location in the proximal femur using finite element models Med Eng Phys 23 657 664
11. JH Keyak 2001 Improved prediction of proximal femoral fracture load using nonlinear finite element models Med Eng Phys 23 165 173
12. M Bessho I Ohnishi J Matsuyama 2007 Prediction of strength and strain of the proximal femur by a CT-based finite element method J Biomech 40 1745 1753
13. KG Faulkner CE Cann BH Hasegawa 1991 Effect of bone distribution on vertebral strength: assessment with patient-specific nonlinear finite element analysis Radiology 179 669 674
14. MJ Silva TM Keaveny WC Hayes 1998 Computed tomography-based finite element analysis predicts failure loads and fracture patterns for vertebral sections J Orthop Res 16 300 308
15. H Martin J Werner R Andresen 1998 Noninvasive assessment of stiffness and failure load of human vertebrae from CT-data Biomed Tech 43 82 88
16. JM Buckley K Loo J Motherway 2007 Comparison of quantitative computed tomography-based measures in predicting vertebral strength Bone 40 767 774
17. RP Crawford CE Cann TM Keaveny 2003 Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography Bone 33 744 750
18. MA Liebschner DL Kopperdahl D Rosenberg 2003 Finite element modeling of the human thoracolumbar spine Spine 28 559 565
19. K Imai I Ohnishi M Bessho 2006 Nonlinear finite element model predicts vertebral bone strength and fracture site Spine 31 1789 1794
20. KC Lian TF Lang JH Keyak 2005 Differences in hip quantitative computed tomography (QCT) measurements of bone mineral density and bone strength between glucocorticoid-treated and glucocorticoid-naive postmenopausal women Osteoporos Int 16 642 650
21. TM Keaveny DW Donley PF Hoffmann 2007 Effects of teriparatide and alendronate on vertebral strength as assessed by finite element modeling of QCT scans in women with osteoporosis J Bone Miner Res 22 149 157
22. LJ Melton III BL Riggs TM Keaveny 2007 Structural determinants of vertebral fracture risk J Bone Miner Res 22 1885 1892
23. H Orimo Y Hayashi M Fukunaga 2001 Diagnostic criteria for primary osteoporosis: year 2000 revision J Bone Miner Metab 19 331 337
24. K Imai I Ohnishi S Yamamoto 2008 In vivo assessment of lumbar vertebral strength in elderly women using computed tomography-based nonlinear finite element model Spine 33 27 32
25. World Health Organization 1994 Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group World Health Organ Tech Rep Ser 843 1 129
26. JP Devogelaer H Broll R Correa-Rotter 1996 Oral alendronate induces progressive increases in bone mass of the spine, hip, and total body over 3 years in postmenopausal women with osteoporosis Bone 18 141 150
27. JR Tucci RP Tonino RD Emkey 1996 Effect of three years of oral alendronate treatment in postmenopausal women with osteoporosis Am J Med 101 488 501
28. DM Black SR Cummings DB Karpf 1996 Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group Lancet 348 1535 1541
29. UA Liberman SR Weiss J Broll 1995 Effect of oral alendronate on bone mineral density and the incidence of fractures in postmenopausal osteoporosis. The Alendronate Phase III Osteoporosis Treatment Study Group N Engl J Med 333 1437 1443
30. SR Cummings DM Black DE Thompson 1998 Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial JAMA 280 2077 2082
31. HA Pols D Felsenberg DA Hanley 1999 Multinational, placebo-controlled, randomized trial of the effects of alendronate on bone density and fracture risk in postmenopausal women with low bone mass: results of the FOSIT study. Fosamax International Trial Study Group Osteoporos Int 9 461 468
32. KE Ensrud DM Black L Palermo 1997 Treatment with alendronate prevents fractures in women at highest risk: results from the Fracture Intervention Trial Arch Intern Med 157 2617 2624
33. MR McClung J San Martin PD Miller 2005 Opposite bone remodeling effects of teriparatide and alendronate in increasing bone mass Arch Intern Med 165 1762 1768
34. DM Black SL Greenspan KE Ensrud 2003 The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis N Engl J Med 349 1207 1215
35. G Dougherty D Newman 1999 Measurement of thickness and density of thin structures by computed tomography: a simulation study Med Phys 26 1341 1348
36. S Prevrhal K Engelke WA Kalender 1999 Accuracy limits for the determination of cortical width and density: the influence of object size and CT imaging parameters Phys Med Biol 44 751 764
37. GY Boivin PM Chavassieux AC Santora 2000 Alendronate increases bone strength by increasing the mean degree of mineralization of bone tissue in osteoporotic women Bone 27 687 694
38. P Roschger S Rinnerthaler J Yates 2001 Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women Bone 29 185 191
39. SR Cummings DB Karpf F Harris 2002 Improvement in spine bone density and reduction in risk of vertebral fractures during treatment with antiresorptive drugs Am J Med 112 281 289
40. LM McNamara PJ Prendergast 2007 Bone remodelling algorithms incorporating both strain and microdamage stimuli J Biomech 40 1381 1391
41. R Balena BC Toolan M Shea 1993 The effects of 2-year treatment with the aminobisphosphonate alendronate on bone metabolism, bone histomorphometry, and bone strength in ovariectomized nonhuman primates J Clin Invest 92 2577 2586
42. KJ Fischer TH Vikoren S Ney 2006 Mechanical evaluation of bone samples following alendronate therapy in healthy male dogs J Biomed Mater Res B Appl Biomater 76 143 148