Molecular mapping deep within a living human organ: Analysis of microvessel function on the timescale of seconds and with sub-micrometre spatial resolutio

Histochemistry and Cell Biology

Volumn 131, Issue 5, 2009, Pages 537-551

  Solder E ^a   Kremser, C ^a   Rohr, I ^a   Hutzler, P ^b   Debbage, Paul ^c  

^a INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c UNIVERSITY OF INNSBRUCK   (Austria)

Author keywords

Functional molecular imaging; Image analysis; Intravital lectin perfusion; Mapping vascular function; Material transfer; Placental cotyledon; Vascular clearance

Indexed keywords

ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; FLUORESCENCE HISTOCHEMISTRY; FLUORESCENCE IMAGING; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; MICROVASCULARIZATION; MICROVASCULATURE; MOLECULAR IMAGING; PRIORITY JOURNAL;

FEMALE; FLUORESCEIN ANGIOGRAPHY; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MICROVESSELS; PLACENTA; PREGNANCY;

EID: 63949083402     PISSN: 09486143     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00418-009-0570-8     Document Type: Article

References (44)

1. AF Altelaar I Klinkert K Jalink RP de Lange RA Adan RM Heeren SR Piersma 2006 Gold-enhanced biomolecular surface imaging of cells and tissue by SIMS and MALDI mass spectrometry Anal Chem 78 734 742
2. M Bassily H Ghabrial RA Smallwood DJ Morgan 1995 Determinants of placental drug transfer: Studies in the isolated perfused human placenta J Pharm Sci 84 1054 1060
3. FC Battaglia 2007 Placental transport: a function of permeability and perfusion Am J Clin Nutr 85 591S 597S
4. A Berhe A Harkes CP Sibley 1988 Effects of histamine on vascular resistance and protein permeability in the isolated dually perfused guinea-pig placenta J Dev Physiol 10 357 369
5. S Bolte FP Cordelieres 2006 A guided tour into subcellular colocalization analysis in light microscopy J Microsc 224 213 232
6. CM Brown 2007 Fluorescence microscopy-avoiding the pitfalls J Cell Sci 120 1703 1705
7. K Carlsson 1991 The influence of specimen refractive index, detector signal, integration and non-uniform scan speed on the imaging properties in confocal microscopy J Microsc 163 167 178
8. B Casey RE Bawdon 2000 Ex vivo human placental transfer of trovafloxacin Infect Dis Obstet Gynecol 8 228 229
9. JW Comeau S Costantino PW Wiseman 2006 A guide to accurate fluorescence microscopy colocalization measurements Biophys J 91 4611 4622
10. JA Conchello JW Lichtman 2005 Optical sectioning microscopy Nat Methods 2 920 931
11. PL Debbage 1996 A systematic histochemical investigation in mammals of the dense glycocalyx glycosylations common to all cells bordering the interstitial fluid compartment of the brain Acta Histochem 98 9 28
12. PL Debbage W Jaschke 2008 Molecular imaging with nanoparticles: giant roles for dwarf actors Histochem Cell Biol 130 5 845 875 10.1007/s00418-008- 0511-y
13. PL Debbage J Griebel M Ried T Gneiting A DeVries P Hutzler 1998 Lectin intravital perfusion studies in tumor-bearing mice: micrometer-resolution, wide-area mapping of microvascular labeling, distinguishing efficiently and inefficiently perfused microregions in the tumor J Histochem Cytochem 46 627 639
14. PL Debbage S Seidl A Kreczy P Hutzler M Pavelka P Lukas 2000 Vascular permeability and hyperpermeability in a murine adenocarcinoma after fractionated radiotherapy: an ultrastructural tracer study Histochem Cell Biol 114 259 275
15. PL Debbage E Sölder S Seidl P Hutzler B Hugl D Öfner A Kreczy 2001 Intravital lectin perfusion analysis of vascular permeability in human micro- and macro-blood vessels Histochem Cell Biol 116 349 359
16. BM Eaton L Leach JA Firth 1993 Permeability of the fetal villous microvasculature in the isolated perfused term human placenta J Physiol 463 141 155
17. G Ernst C Melle B Schimmel A Bleul F von Eggelin 2006 Proteohistography-direct analysis of tissue with high sensitivity and high spatial resolution using ProteinChip technology J Histochem Cytochem 54 13 17
18. D Ford 1993 The nature of clarity in archaeological line drawings J Field Archaeol 20 319 333
19. F Forestier P de Renty G Peytavin E Dohin R Farinotti L Mandelbrot 2001 Maternal-fetal transfer of saquinavir studied in ex vivo placental perfusion model Am J Obstet Gynecol 185 178 181
20. P Friedl K Wolf UH von Andrian G Harms 2007 Biological second and third harmonic generation micro-scopy Curr Pro Cell Biol 4 1 21
21. S Gebb T Stevens 2004 On lung endothelial cell heterogeneity Microvasc Res 68 1 12 Review
22. H Holthöfer I Virtan AL Kariniemi M Hormia E Linder A Miettinen 1982 Ulex europeus I lectin as a marker for vascular endothelium in human tissues Lab Invest 47 60 66
23. CJ Jackson PK Garbett B Nissen L Schrieber 1990 Binding of human endothelium to Ulex europaeus I-coated Dynabeads: application to the isolation of microvascular endothelium J Cell Sci 96 257 262
24. ++ concentrations in the maternal and fetal circulation of the dually perfused human placental cotyledon Bioelectromagnetics 25 329 337
25. T Nanovskaya I Nekhayeva G Hankins M Ahmed 2007 Transfer of methadone across the dually perfused preterm human placental lobule Am J Obstet Gynecol 189 1261.e1 1264.e4
26. AJ North 2006 Seeing is believing? A beginners' guide to practical pitfalls in image acquisition J Cell Biol 172 9 18
27. H Ostermann GVR Born 1986 Comparison of the numbers of plasmalemmal vesicles in arterial and venous endothelia of rats Proc Roy Soc Lond B Biol Sci 227 17 20
28. Pawley J (2006) Handbook of biological confocal microscopy, 3rd edn. Plenum Press/Springer, New York
29. H Pearson 2007 The good, the bad and the ugly Nature 447 138 140
30. J Plendl F Sinowatz R Auerbach 1992 Die Heterogenität des vaskulären Endothels Anatomia, Histologia Embryol J Vet Med Ser C Vol 21 256 262
31. L Radulescu F Antohe V Jinga V Ghetie M Simionescu 2004 Neonatal Fc receptors discriminates and monitors the pathway of native and modified immunoglobulin G in placental endothelial cells Hum Immunol 65 578 585
32. Rasband WS (2007) ImageJ. US National Institutes of Health, Bethesda, Maryland, USA, http://rsb.info.nih.gov/ij/, 1997-2007
33. M Rossner KM Yamada 2004 What's in a picture? The temptation of image manipulation J Cell Biol 166 11 15
34. F Shen L Hodgson JH Price KM Hahn 2008 Digital differential interference contrast autofocus for high-resolution oil-immersion microscopy Cytometry A 73 658 666
35. CJR Sheppard M Gu M Roy 1992 Signal to noise ratio in confocal microscope systems J Microscop 168 209 218
36. Soelder E, Rohr I, Kremser C, Hutzler P, Debbage P (2008) Review. Imaging of placental transport mechanisms. Reproductive Bioengineering, Special Supplement. Eur J Obstet Gynaecol Reprod Biol, (in press)
37. EHK Stelzer 1998 Contrast, resolution, pixelation, dynamic range and signal-to-noise ratio: fundamental limits to resolution in fluorescence light microscopy J Microsc 189 15 24
38. J Stulc H Schneider 1988 Transport of radioactive deoxyglucose by the isolated perfused human placental cotyledon as measured by the paired-tracer dilution medthod. Inconsistency of the transfer rates across the two trophoblast borders with the simultaneously measured rate of transplacental transfer Placenta 9 227 235
39. ++ transfer across the perfused human placental cotyledon Am J Obstet Gynecol 170 162 167
40. Tufte ER (1983) The visual display of quantitative information. Graphics Press, Cheshire, p 197
41. SC Vieira LC Zeferino BB da Silva GA Pinto J Vassallo GAF Carasan N Guimarães de Moraes 2004 Quantification of angiogenesis in cervical cancer: a comparison among three endothelial cell markers Gynecol Oncol 93 121 124
42. A Walch S Rauser S-O Deininger H Höfler 2008 MALDI imaging mass spectrometry for direct tissue analysis: a new frontier for molecular histology Histochem Cell Biol 130 421 434
43. E Wieser D Strohmeyer H Rogatsch W Horninger G Bartsch P Debbage 2004 Access of tumor-derived macromolecules and cells to the blood: an electron microscopical study of structural barriers in microvessel clusters in highly malignant primary prostate carcinomas Prostate 62 123 132
44. M Willingham A Rutherford 1984 The use of osmium-thiocarbohydrazide- osmium (OTO) and ferrcyanide-reduced osmium methods to enhance membrane contrast and preservation in cultured cells J Histochem Cytochem 32 455 460