Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571

Journal of Antibiotics

Volumn 62, Issue 3, 2009, Pages 123-127

  Murakami, Ryo ^a   Shinozaki, Junko ^b   Kajiura, Takayuki ^b   Kozone, Ikuko ^c   Takagi, Motoki ^c   Shin Ya, Kazuo ^d   Seto, Haruo ^e   Hayakawa, Yoichi ^f  

^a DAIICHI SANKYO CO   (Japan)

^b AJINOMOTO CO INC   (Japan)

^c Koto ku   (Japan)

^d NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^e TOKYO UNIVERSITY OF AGRICULTURE   (Japan)

^f TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Ammocidin; Cytotoxic; Macrolide; Saccharothrix

Indexed keywords

AMMOCIDIN A; AMMOCIDIN B; AMMOCIDIN C; AMMOCIDIN D; MACROLIDE; UNCLASSIFIED DRUG;

ACTINOMYCETALES; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SACCHAROTHRIX;

ACTINOMYCETALES; ANTIBIOTICS, ANTINEOPLASTIC; CARBOHYDRATE SEQUENCE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MACROLIDES; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET;

SACCHAROTHRIX;

EID: 63849333684     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2008.23     Document Type: Article

References (2)

1. Murakami, R, Tomikawa, T, Shin-ya, K, Seto, H & Hayakawa, Y Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. I. Production, isolation and biological activity. J Antibiot 54, 710-713 (2001).
2. Murakami, R, Tomikawa, T, Shin-ya, K, Seto, H & Hayakawa, Y Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. II. Physico-chemical properties and structure elucidation. J Antibiot 54, 714-717 (2001).