-
1
-
-
33846332080
-
New mechanisms and targets in the treatment of bone fragility
-
Martin TJ, Seeman E. New mechanisms and targets in the treatment of bone fragility. Clin Sci 2007 112 : 77 91.
-
(2007)
Clin Sci
, vol.112
, pp. 77-91
-
-
Martin, T.J.1
Seeman, E.2
-
2
-
-
0034455103
-
Birth and death of bone cells: Basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis
-
Manolagas SC. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 2000 21 : 115 37.
-
(2000)
Endocr Rev
, vol.21
, pp. 115-137
-
-
Manolagas, S.C.1
-
3
-
-
33947497852
-
Osteoclasts: What do they do and how do they do it?
-
Teitelbaum SL. Osteoclasts: what do they do and how do they do it? Am J Pathol 2007 170 : 427 35.
-
(2007)
Am J Pathol
, vol.170
, pp. 427-435
-
-
Teitelbaum, S.L.1
-
4
-
-
0037673945
-
Osteoclast differentiation and activation
-
Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003 423 : 337 42.
-
(2003)
Nature
, vol.423
, pp. 337-342
-
-
Boyle, W.J.1
Simonet, W.S.2
Lacey, D.L.3
-
5
-
-
0033304730
-
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families
-
Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ. Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families. Endocr Rev 1999 20 : 345 57.
-
(1999)
Endocr Rev
, vol.20
, pp. 345-357
-
-
Suda, T.1
Takahashi, N.2
Udagawa, N.3
Jimi, E.4
Gillespie, M.T.5
Martin, T.J.6
-
6
-
-
4344625855
-
Expression of receptor activator of NF-kappaB ligand (RANKL) mRNA in human multiple myeloma cells
-
Heider U, Zavrski I, Jakob C. Expression of receptor activator of NF-kappaB ligand (RANKL) mRNA in human multiple myeloma cells. J Cancer Res Clin Oncol 2004 130 : 469 74.
-
(2004)
J Cancer Res Clin Oncol
, vol.130
, pp. 469-474
-
-
Heider, U.1
Zavrski, I.2
Jakob, C.3
-
7
-
-
9644302960
-
Increased expression of receptor activator of NF-kappaB ligand (RANKL), its receptor RANK and its decoy receptor osteoprotegerin in the colon of Crohn's disease patients
-
Franchimont N, Reenaers C, Lambert C. Increased expression of receptor activator of NF-kappaB ligand (RANKL), its receptor RANK and its decoy receptor osteoprotegerin in the colon of Crohn's disease patients. Clin Exp Immunol 2004 138 : 491 8.
-
(2004)
Clin Exp Immunol
, vol.138
, pp. 491-498
-
-
Franchimont, N.1
Reenaers, C.2
Lambert, C.3
-
8
-
-
33646353397
-
Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes
-
Miranda-Carus ME, Benito-Miguel M, Balsa A. Peripheral blood T lymphocytes from patients with early rheumatoid arthritis express RANKL and interleukin-15 on the cell surface and promote osteoclastogenesis in autologous monocytes. Arthritis Rheum 2006 54 : 1151 64.
-
(2006)
Arthritis Rheum
, vol.54
, pp. 1151-1164
-
-
Miranda-Carus, M.E.1
Benito-Miguel, M.2
Balsa, A.3
-
9
-
-
0031005576
-
Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
-
Simonet WS, Lacey DL, Dunstan CR. Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 1997 89 : 309 19.
-
(1997)
Cell
, vol.89
, pp. 309-319
-
-
Simonet, W.S.1
Lacey, D.L.2
Dunstan, C.R.3
-
10
-
-
0033611467
-
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
-
Kong YY, Yoshida H, Sarosi I. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999 397 : 315 23.
-
(1999)
Nature
, vol.397
, pp. 315-323
-
-
Kong, Y.Y.1
Yoshida, H.2
Sarosi, I.3
-
11
-
-
12944262423
-
RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism
-
Li J, Sarosi I, Yan XQ. RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism. Proc Natl Acad Sci U S A 2000 97 : 1566 71.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 1566-1571
-
-
Li, J.1
Sarosi, I.2
Yan, X.Q.3
-
12
-
-
0032079445
-
Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
-
Bucay N, Sarosi I, Dunstan CR. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998 12 : 1260 68.
-
(1998)
Genes Dev
, vol.12
, pp. 1260-1268
-
-
Bucay, N.1
Sarosi, I.2
Dunstan, C.R.3
-
13
-
-
0032577903
-
Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin
-
Mizuno A, Amizuka N, Irie K. Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun 1998 247 : 610 15.
-
(1998)
Biochem Biophys Res Commun
, vol.247
, pp. 610-615
-
-
Mizuno, A.1
Amizuka, N.2
Irie, K.3
-
14
-
-
33645272569
-
Osteoprotegerin as a potential therapy for osteoporosis
-
Hamdy NA. Osteoprotegerin as a potential therapy for osteoporosis. Curr Osteoporos Rep 2005 3 : 121 5.
-
(2005)
Curr Osteoporos Rep
, vol.3
, pp. 121-125
-
-
Hamdy, N.A.1
-
15
-
-
3342982829
-
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
-
Bekker PJ, Holloway DL, Rasmussen AS. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res 2004 19 : 1059 66.
-
(2004)
J Bone Miner Res
, vol.19
, pp. 1059-1066
-
-
Bekker, P.J.1
Holloway, D.L.2
Rasmussen, A.S.3
-
16
-
-
33644849960
-
A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women
-
Bekker PJ, Holloway DL, Rasmussen AS. A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women. J Bone Miner Res 2005 20 : 2275 82.
-
(2005)
J Bone Miner Res
, vol.20
, pp. 2275-2282
-
-
Bekker, P.J.1
Holloway, D.L.2
Rasmussen, A.S.3
-
17
-
-
33744992495
-
Osteoporosis
-
Sambrook P, Cooper C. Osteoporosis. Lancet 2006 367 : 2010 18.
-
Lancet
, vol.367
, Issue.2006
, pp. 2010-2018
-
-
Sambrook, P.1
Cooper, C.2
-
18
-
-
37249045914
-
T cells: Unexpected players in the bone loss induced by estrogen deficiency and in basal bone homeostasis
-
Weitzmann MN, Pacifici R. T cells: unexpected players in the bone loss induced by estrogen deficiency and in basal bone homeostasis. Ann N Y Acad Sci 2007 1116 : 360 75.
-
(2007)
Ann N y Acad Sci
, vol.1116
, pp. 360-375
-
-
Weitzmann, M.N.1
Pacifici, R.2
-
19
-
-
0037398261
-
Role of RANK ligand in mediating increased bone resorption in early postmenopausal women
-
Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle WJ, Lacey DL, Riggs BL. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest 2003 111 : 1221 30.
-
(2003)
J Clin Invest
, vol.111
, pp. 1221-1230
-
-
Eghbali-Fatourechi, G.1
Khosla, S.2
Sanyal, A.3
Boyle, W.J.4
Lacey, D.L.5
Riggs, B.L.6
-
20
-
-
33344469853
-
Denosumab in postmenopausal women with low bone mineral density
-
McClung MR, Lewiecki EM, Cohen SB. Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 2006 354 : 821 31.
-
(2006)
N Engl J Med
, vol.354
, pp. 821-831
-
-
McClung, M.R.1
Lewiecki, E.M.2
Cohen, S.B.3
-
21
-
-
38749105490
-
Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD
-
Lewiecki EM, Miller PD, McClung MR. Two-year treatment with denosumab (AMG 162) in a randomized phase 2 study of postmenopausal women with low BMD. J Bone Miner Res 2007 22 : 1832 41.
-
(2007)
J Bone Miner Res
, vol.22
, pp. 1832-1841
-
-
Lewiecki, E.M.1
Miller, P.D.2
McClung, M.R.3
-
22
-
-
0036172368
-
Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis
-
Romas E, Gillespie MT, Martin TJ. Involvement of receptor activator of NFkappaB ligand and tumor necrosis factor-alpha in bone destruction in rheumatoid arthritis. Bone 2002 30 : 340 46.
-
(2002)
Bone
, vol.30
, pp. 340-346
-
-
Romas, E.1
Gillespie, M.T.2
Martin, T.J.3
-
23
-
-
34247125697
-
Inflammation-induced bone loss: Can it be prevented?
-
Romas E, Gillespie MT. Inflammation-induced bone loss: can it be prevented? Rheum Dis Clin North Am 2006 32 : 759 73.
-
(2006)
Rheum Dis Clin North Am
, vol.32
, pp. 759-773
-
-
Romas, E.1
Gillespie, M.T.2
-
24
-
-
28644440235
-
Bone loss in inflammatory arthritis: Mechanisms and therapeutic approaches with bisphosphonates
-
Romas E. Bone loss in inflammatory arthritis: mechanisms and therapeutic approaches with bisphosphonates. Best Pract Res Clin Rheumatol 2005 19 : 1065 79.
-
(2005)
Best Pract Res Clin Rheumatol
, vol.19
, pp. 1065-1079
-
-
Romas, E.1
-
25
-
-
54949091800
-
Denosumab inhibits RANKL, reducing progression of the total sharp score and bone erosions in patients with rheumatoid arthritis: 12-month X-ray results
-
van der Heijde D, Cohen S, Sharp J. Denosumab inhibits RANKL, reducing progression of the total sharp score and bone erosions in patients with rheumatoid arthritis: 12-month X-ray results. Arthritis Rheum 2007 56 (Suppl S698.
-
(2007)
Arthritis Rheum
, vol.56
-
-
Van Der Heijde, D.1
Cohen, S.2
Sharp, J.3
-
26
-
-
84927683786
-
Denosumab-mediated increase of hand bone mineral density in patients with rheumatoid arthritis is associated with decreased progression of bone erosion
-
Deodar A, Dore R, Sharp J. Denosumab-mediated increase of hand bone mineral density in patients with rheumatoid arthritis is associated with decreased progression of bone erosion. Arthritis Rheum 2007 56 (Suppl S944.
-
(2007)
Arthritis Rheum
, vol.56
-
-
Deodar, A.1
Dore, R.2
Sharp, J.3
-
27
-
-
0036792512
-
Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis
-
Romas E, Sims NA, Hards DK. Osteoprotegerin reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis. Am J Pathol 2002 161 : 1419 27.
-
(2002)
Am J Pathol
, vol.161
, pp. 1419-1427
-
-
Romas, E.1
Sims, N.A.2
Hards, D.K.3
-
29
-
-
33845193025
-
Myeloma bone disease: Pathogenetic mechanisms and clinical assessment
-
Silvestris F, Lombardi L, De Matteo M, Bruno A, Dammacco F. Myeloma bone disease: pathogenetic mechanisms and clinical assessment. Leuk Res 2007 31 : 129 38.
-
(2007)
Leuk Res
, vol.31
, pp. 129-138
-
-
Silvestris, F.1
Lombardi, L.2
De Matteo, M.3
Bruno, A.4
Dammacco, F.5
-
31
-
-
38749106994
-
RANK ligand as a therapeutic target for bone metastases and multiple myeloma
-
Roodman GD, Dougall WC. RANK ligand as a therapeutic target for bone metastases and multiple myeloma. Cancer Treat Rev 2008 34 : 92 101.
-
(2008)
Cancer Treat Rev
, vol.34
, pp. 92-101
-
-
Roodman, G.D.1
Dougall, W.C.2
-
32
-
-
35348897212
-
Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases
-
Lipton A, Steger GG, Figueroa J. Randomized active-controlled phase II study of denosumab efficacy and safety in patients with breast cancer-related bone metastases. J Clin Oncol 2007 25 : 4431 7.
-
(2007)
J Clin Oncol
, vol.25
, pp. 4431-4437
-
-
Lipton, A.1
Steger, G.G.2
Figueroa, J.3
-
33
-
-
34250737779
-
Clinical value of bisphosphonates in cancer therapy
-
Luftner D, Henschke P, Possinger K. Clinical value of bisphosphonates in cancer therapy. Anticancer Res 2007 27 : 1759 68.
-
(2007)
Anticancer Res
, vol.27
, pp. 1759-1768
-
-
Luftner, D.1
Henschke, P.2
Possinger, K.3
-
34
-
-
33847771427
-
Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis
-
Daubine F, Le Gall C, Gasser J, Green J, Clezardin P. Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis. J Natl Cancer Inst 2007 99 : 322 30.
-
(2007)
J Natl Cancer Inst
, vol.99
, pp. 322-330
-
-
Daubine, F.1
Le Gall, C.2
Gasser, J.3
Green, J.4
Clezardin, P.5
-
35
-
-
0033932526
-
Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone
-
Menaa C, Reddy SV, Kurihara N. Enhanced RANK ligand expression and responsivity of bone marrow cells in Paget's disease of bone. J Clin Invest 2000 105 : 1833 8.
-
(2000)
J Clin Invest
, vol.105
, pp. 1833-1838
-
-
Menaa, C.1
Reddy, S.V.2
Kurihara, N.3
-
36
-
-
33744765838
-
Paget's disease of bone and genetic disorders of RANKL/OPG/RANK/NF-kappaB signaling
-
Whyte MP. Paget's disease of bone and genetic disorders of RANKL/OPG/RANK/NF-kappaB signaling. Ann N Y Acad Sci 2006 1068 : 143 64.
-
(2006)
Ann N y Acad Sci
, vol.1068
, pp. 143-164
-
-
Whyte, M.P.1
-
37
-
-
24044504089
-
Recombinant osteoprotegerin for juvenile Paget's disease
-
Cundy T, Davidson J, Rutland MD, Stewart C, DePaoli AM. Recombinant osteoprotegerin for juvenile Paget's disease. N Engl J Med 2005 353 : 918 23.
-
(2005)
N Engl J Med
, vol.353
, pp. 918-923
-
-
Cundy, T.1
Davidson, J.2
Rutland, M.D.3
Stewart, C.4
Depaoli, A.M.5
-
38
-
-
21244482173
-
Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB
-
Morgan T, Atkins GJ, Trivett MK. Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB. Am J Pathol 2005 167 : 117 28.
-
(2005)
Am J Pathol
, vol.167
, pp. 117-128
-
-
Morgan, T.1
Atkins, G.J.2
Trivett, M.K.3
-
39
-
-
33846126286
-
The cellular and molecular biology of periprosthetic osteolysis
-
Purdue PE, Koulouvaris P, Potter HG, Nestor BJ, Sculco TP. The cellular and molecular biology of periprosthetic osteolysis. Clin Orthop Relat Res 2007 454 : 251 61.
-
(2007)
Clin Orthop Relat Res
, vol.454
, pp. 251-261
-
-
Purdue, P.E.1
Koulouvaris, P.2
Potter, H.G.3
Nestor, B.J.4
Sculco, T.P.5
-
40
-
-
35649019710
-
Periprosthetic osteolysis and its association with RANKL expression
-
Veigl D, Niederlova J, Krystufkova O. Periprosthetic osteolysis and its association with RANKL expression. Physiol Res 2007 56 : 455 62.
-
(2007)
Physiol Res
, vol.56
, pp. 455-462
-
-
Veigl, D.1
Niederlova, J.2
Krystufkova, O.3
-
41
-
-
0141684971
-
The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis
-
Black DM, Greenspan SL, Ensrud KE. The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis. N Engl J Med 2003 349 : 1207 15.
-
(2003)
N Engl J Med
, vol.349
, pp. 1207-1215
-
-
Black, D.M.1
Greenspan, S.L.2
Ensrud, K.E.3
-
42
-
-
33747682160
-
Effects of teriparatide, alendronate, or both on bone turnover in osteoporotic men
-
Finkelstein JS, Leder BZ, Burnett SM. Effects of teriparatide, alendronate, or both on bone turnover in osteoporotic men. J Clin Endocrinol Metab 2006 91 : 2882 7.
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 2882-2887
-
-
Finkelstein, J.S.1
Leder, B.Z.2
Burnett, S.M.3
-
43
-
-
33749518855
-
Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia
-
Iwata K, Li J, Follet H, Phipps RJ, Burr DB. Bisphosphonates suppress periosteal osteoblast activity independently of resorption in rat femur and tibia. Bone 2006 39 : 1053 8.
-
(2006)
Bone
, vol.39
, pp. 1053-1058
-
-
Iwata, K.1
Li, J.2
Follet, H.3
Phipps, R.J.4
Burr, D.B.5
-
44
-
-
13244267455
-
Osteoclast-derived activity in the coupling of bone formation to resorption
-
Martin TJ, Sims NA. Osteoclast-derived activity in the coupling of bone formation to resorption. Trends Mol Med 2005 11 : 76 81.
-
(2005)
Trends Mol Med
, vol.11
, pp. 76-81
-
-
Martin, T.J.1
Sims, N.A.2
-
45
-
-
15944413442
-
Severely suppressed bone turnover: A potential complication of alendronate therapy
-
Odvina CV, Zerwekh JE, Rao DS, Maalouf N, Gottschalk FA, Pak CY. Severely suppressed bone turnover: a potential complication of alendronate therapy. J Clin Endocrinol Metab 2005 90 : 1294 1301.
-
(2005)
J Clin Endocrinol Metab
, vol.90
, pp. 1294-1301
-
-
Odvina, C.V.1
Zerwekh, J.E.2
Rao, D.S.3
Maalouf, N.4
Gottschalk, F.A.5
Pak, C.Y.6
-
46
-
-
34147179587
-
Subtrochanteric insufficiency fractures in patients on alendronate therapy: A caution
-
Goh SK, Yang KY, Koh JS. Subtrochanteric insufficiency fractures in patients on alendronate therapy: a caution. J Bone Joint Surg Br 2007 89 : 349 53.
-
(2007)
J Bone Joint Surg Br
, vol.89
, pp. 349-353
-
-
Goh, S.K.1
Yang, K.Y.2
Koh, J.S.3
-
47
-
-
40949099444
-
Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate
-
Lenart BA, Lorich DG, Lane JM. Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med 2008 358 : 1304 6.
-
(2008)
N Engl J Med
, vol.358
, pp. 1304-1306
-
-
Lenart, B.A.1
Lorich, D.G.2
Lane, J.M.3
-
48
-
-
34848841461
-
Bisphosphonate-associated osteonecrosis of the jaw: Report of a task force of the American Society for Bone and Mineral Research
-
Khosla S, Burr D, Cauley J. Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res 2007 22 : 1479 91.
-
(2007)
J Bone Miner Res
, vol.22
, pp. 1479-1491
-
-
Khosla, S.1
Burr, D.2
Cauley, J.3
|