Intrahippocampal infusion of botulinum neurotoxin e (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy

Epilepsia

Volumn 50, Issue 4, 2009, Pages 963-966

  Antonucci, Flavia ^a   Bozzi, Yuri ^a   Caleo, Matteo ^a  

^a CNR Consiglio Nazionale delle Ricerche   (Italy)

Author keywords

Granule cell dispersion; Kainic acid; Mesial temporal lobe epilepsy; SNAP 25; Spontaneous recurrent seizures

Indexed keywords

BOTULINUM TOXIN E;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ELECTROENCEPHALOGRAPHY; HIPPOCAMPUS; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECURRENT DISEASE; TEMPORAL LOBE EPILEPSY;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-DYSKINESIA AGENTS; BOTULINUM TOXINS; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; EPILEPSY, TEMPORAL LOBE; HIPPOCAMPUS; KAINIC ACID; MALE; MICE; MICE, INBRED C57BL;

EID: 63849196530     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2008.01983.x     Document Type: Article

References (12)

1. Antonucci F, Di Garbo A, Novelli E, Manno I, Sartucci F, Bozzi Y, Caleo M 2008a) Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy. Exp Neurol 210 : 388 401.
2. Antonucci F, Rossi C, Gianfranceschi L, Rossetto O, Caleo M 2008b) Long-distance retrograde effects of botulinum neurotoxin A. J Neurosci 28 : 3689 3696.
3. Bozzi Y, Costantin L, Antonucci F, Caleo M 2006) Action of botulinum neurotoxins in the central nervous system: antiepileptic effects. Neurotox Res 9 : 197 203.
4. Costantin L, Bozzi Y, Richichi C, Viegi A, Antonucci F, Funicello M, Gobbi M, Mennini T, Rossetto O, Montecucco C, Maffei L, Vezzani A, Caleo M 2005) Antiepileptic effects of botulinum neurotoxin E. J Neurosci 25 : 1943 1951.
5. Franklin KBJ, Paxinos G 1997) The mouse brain in stereotaxic coordinates. Academic Press, San Diego, CA.
6. Gouder N, Fritschy JM, Boison D 2003) Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy. Epilepsia 44 : 877 885.
7. Gouder N, Scheurer L, Fritschy JM, Boison D 2004) Overexpression of adenosine kinase in epileptic hippocampus contributes to epileptogenesis. J Neurosci 24 : 692 701.
8. Heinrich C, Nitta N, Flubacher A, Muller M, Fahrner A, Kirsch M, Freiman T, Suzuki F, Depaulis A, Frotscher M, Haas CA 2006) Reelin deficiency and displacement of mature neurons, but not neurogenesis, underlie the formation of granule cell dispersion in the epileptic hippocampus. J Neurosci 26 : 4701 4713.
9. Manno I, Antonucci F, Caleo M, Bozzi Y 2007) BoNT/E prevents seizure-induced activation of caspase 3 in the rat hippocampus. Neuroreport 18 : 577 580.
10. Riban V, Bouilleret V, Pham-Le BT, Fritschy JM, Marescaux C, Depaulis A 2002) Evolution of hippocampal epileptic activity during the development of hippocampal sclerosis in a mouse model of temporal lobe epilepsy. Neuroscience 112 : 101 111.
11. Stein AG, Eder HG, Blum DE, Drachev A, Fisher RS 2000) An automated drug delivery system for focal epilepsy. Epilepsy Res 39 : 103 114.
12. Suzuki F, Heinrich C, Boehrer A, Mitsuya K, Kurokawa K, Matsuda M, Depaulis A 2005) Glutamate receptor antagonists and benzodiazepine inhibit the progression of granule cell dispersion in a mouse model of mesial temporal lobe epilepsy. Epilepsia 46 : 193 202.