Morphine is an arteriolar vasodilator in man

British Journal of Clinical Pharmacology

Volumn 67, Issue 4, 2009, Pages 386-393

  Afshari, Reza ^b   Maxwell, Simon R J ^c   Webb, David J ^c   Bateman, D Nicholas ^a  

^a ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^b MASHHAD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Histamine; Morphine; Naloxone; Nitric oxide; Opioid; Vasodilatation

Indexed keywords

ANTIHISTAMINIC AGENT; HISTAMINE H1 RECEPTOR ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST; MORPHINE; NALOXONE; NITRIC OXIDE; OPIATE RECEPTOR;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE CALCULATION; DRUG MECHANISM; DRUG TOLERANCE; FOREARM BLOOD FLOW; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; VASODILATATION; VEIN OCCLUSION PLETHYSMOGRAPHY;

ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; FOREARM; HISTAMINE; HUMANS; INFUSIONS, INTRA-ARTERIAL; MALE; MIDDLE AGED; MORPHINE; PLETHYSMOGRAPHY; REGIONAL BLOOD FLOW; TREATMENT OUTCOME; VASODILATION; VASODILATOR AGENTS; YOUNG ADULT;

EID: 63849196405     PISSN: 03065251     EISSN: 13652125     Source Type: Journal    
DOI: 10.1111/j.1365-2125.2009.03364.x     Document Type: Article

References (34)

1. Timmis AD, Rothman MT, Henderson MA, Geal PW, Chamberlain DA. Haemodynamic effects of intravenous morphine in patients with acute myocardial infarction complicated by severe left ventricular failure. BMJ 1980 280 : 980 2.
2. Fahmy NR, Sunder N, Soter NA. Role of histamine in the hemodynamic and plasma catecholamine responses to morphine. Clin Pharmacol Ther 1983 33 : 615 20.
3. Petry NM, Bickel WK, Huddleston J, Tzanis E, Badger GJ. A comparison of subjective, psychomotor and physiological effects of a novel muscarinic analgesic, LY297802 tartrate, and oral morphine in occasional drug users. Drug Alcohol Depend 1998 50 : 129 36.
4. Lowenstein E, Hallowell P, Levine FH, Daggett WM, Austen WG, Laver MB. Cardiovascular response to large doses of intravenous morphine in man. N Engl J Med 1969 281 : 1389 93.
5. Mildh LH, Tuomisto LM, Scheinin M, Kirvela OA. Morphine-induced cardiovascular stimulation: the effects of two doses on healthy subjects. Anesth Analg 2000 91 : 51 7.
6. Grossman M, Abiose A, Tangphao O, Blaschke TF, Hoffman BB. Morphine-induced venodilation in humans. Clin Pharm Ther 1996 60 : 554 60.
7. Pugsley MK. The diverse molecular mechanisms responsible for the actions of opioids on the cardiovascular system. Pharmacol Ther 2002 93 : 51 75.
8. Wilkinson IB, Webb DJ. Venous occlusion plethysmography in cardiovascular research: methodology and clinical applications. Br J Clin Pharmacol 2001 52 : 631 46.
9. Dux M, Schwenger N, Messlinger K. Possible role of histamine (H1- and H2-) receptors in the regulation of meningeal blood flow. Br J Pharmacol 2002 137 : 874 80.
10. Grossmann M, Jamieson MJ, Kirch W. Histamine response and local cooling in the human skin: involvement of H1- and H2-receptors. Br J Clin Pharmacol 1998 1999 : 216 22.
11. Clough GF, Bennett AR, Church MK. Effects of H1 antagonists on the cutaneous vascular response to histamine and bradykinin: a study using scanning laser Doppler imaging. Br J Dermatol 1998 138 : 806 14.
12. Stroes ES, Luscher TF, de Groot FG, Koomans HA, Rabelink TJ. Cylosporin A increases nitric oxide activity in vivo. Hypertension 1997 29 : 570 5.
13. Verhaar MC, Strachan FE, Newby DE, Cruden NL, Koomnans HA, Rabelink TJ, Webb DJ. Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade. Circulation 1998 97 : 752 6.
14. Introna RP, Bridges MT, Yodlowski EH, Grover TE, Pruett JK. Direct effects of fentanyl on canine coronary artery rings. Life Sci 1995 56 : 1265 73.
15. el Sharkawy TY, al-Shireida MF, Pilcher CW. Vascular effects of some opioid receptor agonists. Can J Physiol Pharmacol 1991 69 : 846 51.
16. Greenberg S, McGowan C, Xie J, Summer WR. Selective pulmonary and venous smooth muscle relaxation by furosemide: a comparison with morphine. J Pharmacol Exp Ther 1994 270 : 1077 85.
17. Owen JA, Sitar DS, Berger L, Brownell L, Duke PC, Mitenko PA. Age-related morphine kinetics. Clin Pharmacol Ther 1983 34 : 364 8.
18. Schulte H, Sollevi A, Segerdahl AM. Dose-dependent effects of morphine on experimentally induced cutaneous pain in healthy volunteers. Pain 2005 116 : 366 74.
19. Darke S, Sunjic S, Zador D, Prolov T. A comparison of blood toxicology of heroin-related deaths and current heroin users in Sydney, Australia. Drug Alcohol Depend 1997 47 : 45 53.
20. Doenicke A, Moss J, Lorenz W, Hoernecke R. Intravenous morphine and nalbuphine increase histamine and catecholamine release without accompanying hemodynamic changes. Clin Pharmacol Ther 1995 58 : 81 9.
21. Flacke JW, Flacke WE, Bloor BC, Van Etten AP, Kripke BJ. Histamine release by four narcotics: a double-blind study in humans. Anesth Analg 1987 66 : 723 30.
22. Rosow CE, Philbin DM, Keegan CR, Moss J. Hemodynamics and histamine release during induction with sufentanil or fentanyl. Anesthesiology 1984 60 : 489 91.
23. Philbin DM, Moss J, Akins CW, Rosow CE, Kono K, Schneider RC, VerLee TR, Savarese JJ. The use of H1 and H2 histamine antagonists with morphine anesthesia: a double-blind study. Anesthesiology 1981 55 : 292 9.
24. Ebert TJ, Ficke DJ, Arain SR, Holtz MN, Shankar H. Vasodilatation from sufentanil in humans. Anesth Analg 2005 101 : 1677 80.
25. Noseir RK, Ficke DJ, Kundu A, Arain SR, Ebert TJ. Sympathetic and vascular consequences from remifentanil in humans. Anesth Analg 2003 96 : 1645 50.
26. Lantoine F, Iouzalen L, Devynck M, Brussel EM, David-Dufilho M. Nitric oxide production in human endothelial cells stimulated by histamine requires Ca2+ influx. Biochem J 1998 330 : 695 9.
27. Mayhan WG. Nitric oxide accounts for histamine-induced increase in macromolecular extravasation. Am J Physiol 1994 266 : H2369 73.
28. Horan KL, Adamski SW, Ayele W, Langone JJ, Grega GJ. Evidence that prolonged histamine suffusions produce transient increases in vascular permeability subsequent to the formation of venular macromolecular leakage sites. Am J Pathol 1986 123 : 570 6.
29. Stefano GB, Hartman A, Bilfinger TV, Magazine HI, Liu Y, Casares F, Goligorsky MS. Presence of the mu3 opiate receptor in endothelial cells. Coupling to nitric oxide production and vasodilatation. J Biol Chem 1995 270 : 30290 3.
30. Newby DE, Wright RA, Labinjoh C, Ludlam CA, Fox KA, Boon NA, Webb DJ. Endothelial dysfunction, impaired endogenous fibrinolysis and cigarette smoking: a mechanism for arterial thrombosis and myocardial infarction. Circulation 1999 99 : 1411 15.
31. Afshari R. The cardiovascular effects of opioid analgesics: studies on the role of opioid and non-opioid receptors in man. PhD Thesis, University of Edinburgh, 2005.
32. Fisher MM, Harle DG, Baldo BA. Anaphylactoid reactions to narcotic analgesics. Clin Rev Allergy 1991 9 : 309 18.
33. Gooch I, Gwinnutt C. Anaphylaxis to intrathecal diamorphine. Resuscitation 2006 70 : 470 3.
34. Dettmeyer R, Schmidt P, Musselhoff F, Dreisvogt C, Madea B. Pulmonary edema in fatal heroin overdose: immunohistological investigations with IgE, collagen IV and laminin - no increase of defects of alveolar-capillary membranes. Forensic Sci Int 2000 110 : 87 96.