Histamine response and local cooling in the human skin: Involvement of H1- and H2-receptors

British Journal of Clinical Pharmacology

Volumn 48, Issue 2, 1999, Pages 216-222

  Grossmann, M ^a   Jamieson, M J ^b   Kirch, W ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Cetirizine; Cimetidine; H1 receptors; H2 receptors; Histamine; Iontophoresis; Laser Doppler fluximetry; Local cooling

Indexed keywords

CETIRIZINE; CIMETIDINE; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; HUMAN EXPERIMENT; IONTOPHORESIS; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SKIN BLOOD FLOW; SKIN TEMPERATURE; VASODILATATION;

ADULT; CETIRIZINE; CIMETIDINE; COLD; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HISTAMINE H1 ANTAGONISTS; HISTAMINE H2 ANTAGONISTS; HISTAMINE RELEASE; HUMANS; IONTOPHORESIS; LASER-DOPPLER FLOWMETRY; MALE; RECEPTORS, HISTAMINE H1; RECEPTORS, HISTAMINE H2; REGIONAL BLOOD FLOW; SKIN; SKIN PHYSIOLOGY;

EID: 0032795508     PISSN: 03065251     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2125.1999.00994.x     Document Type: Article

References (46)

1. 1 Wanderer AA. Cold urticaria syndromes: historical background, diagnostic classification, clinical and laboratory characteristics, pathogenesis, and management. J Allergy Clin Immunol 1990; 85: 965-981.
2. 2 Ekenvall L, Lindblad LE, Norbeck O, Etzell BM. α-Adrenoceptors and cold-induced vasoconstriction in human finger skin. Am J Physiol 1988; 255: H1000-H1003.
3. 3 Freedman RR, Moten M, Migaly P, Mayes M. Cold-induced potentiation of alpha 2-adrenergic vasoconstriction in primary Raynaud's disease. Arthritis Rheum 1993; 36: 685-690.
4. 4 Van den Brande P, De Coninck A, Lievens P. Skin microcirculation responses to severe local cooling. Int J Microcirc Clin Exp 1997; 17: 55-60.
5. 5 Greaves MW, Sabroe RA. Histamine: the quintessential mediator. J Dermatol 1996; 23: 735-740.
6. 6 Archer CB, Greaves MW. H3 receptors and regulation of histamine turnover in skin: a new approach? Skin Pharmacol 1993; 6: 81-84.
7. 7 Koss MC. Histamine H3 receptor activation inhibits sympathetic-cholinergic responses in cats. Eur J Pharmacol 1994; 257: 109-115.
8. 8 Greaves MW, Davies MG. Histamine receptors in human skin: indirect evidence. Br J Dermatol 1982; 107(Suppl 23): 101-105.
9. 9 Vigorito C, Giordano A, De Caprio L, et al. Effects of histamine on coronary hemodynamics in humans: role of H1 and H2 receptors. J Am Coll Cardiol 1987; 10: 1207-1213.
10. 10 Dachman WD, Bedarida G, Blaschke TF, Hoffman BB. Histamine-induced venodilation in human beings involves both H1 and H2 receptor subtypes. J Allergy Clin Immunol 1994; 93: 606-614.
11. 11 Jansen-Olesen J, Ottosson A, Cantera L, et al. Role of endothelium and nitric oxide in histamine-induced responses in human cranial arteries and detection of mRNA encoding H1-and H2-receptors by RT-PCR. Br J Pharmacol 1997; 121: 41-48.
12. 12 Kajekar R, Moore PK, Brain SD. Essential role for nitric oxide in ncurogenic inflammation in rat cutaneous microcirculation. Evidence for an endothelium-independent mechanism. Circ Res 1995; 76: 441-447.
13. 13 Monge L, Garcia-Villalon AL, Montoya JJ, et al. Role of the endothelium in the response to cholinoceptor stimulation of rabbit ear and femoral arteries during cooling. Br J Pharmacol 1993; 109: 61-67.
14. 14 Fernandez N, Monge L, Garcia-Villalon AL, Garcia JL, Gomez B, Dieguez G. Cooling effects on nitric oxide production by rabbit car and femoral arteries during cholinergic stimulation. Br J Pharmacol 1994; 113: 550-554.
15. 15 Schoeffter P, Godfraind T. Histamine receptors in the smooth muscle of human internal mammary artery and saphenous vein. Pharmacol Toxicol 1989; 64: 64-71.
16. 16 Fernandez N, Garcia-Villalon AL, Borbujo J, et al. Cooling effects on the histaminergic response of rabbit ear and femoral arteries: role of the endothelium. Acta Physiol Scand 1994; 151: 441-451.
17. 17 Van Neste D. Skin response to histamine. Reproducibility study of the dry skin prick test method and of the evaluation of microvascular changes with laser Doppler flowmetry. Acta Derm Venereol 1991; 71: 25-28.
18. 18 Berardesca E, Gabba P, Nume A, Rabbiosi G, Maibach HI. Objective prick test evaluation: non-invasive techniques. Acta Derm Venereol 1992; 72: 261-263.
19. 19 Van Neste D, Leroy DT, de Brouwer B, Rihoux JP. Histamine-induced skin reactions using iontophoresis and H1-blockade. Inflamm Res 1996; 45(Stippl 1): S48-S49.
20. 20 Magerl W, Westerman RA, Mohner B, Handwerker HO. Properties of transdermal histamine iontophoresis: differential effects of season, gender, and body region. J Invest Dermatol 1990; 94: 347-352.
21. 21 Gengo FM, Dabronzo J, Yurchak A, Love S, Miller JK. The relative antihistaminic and psychomotor effects of hydroxyzine and cetirizine. Clin Pharmacol Ther 1987; 42: 265-272.
22. 22 Richards DA. Comparative pharmacodynamics and pharmacokinetics of cimetidine and ranitidine. J Clin Gastroenterol 1983; 5: 81-90.
23. 23 Kalogeromitros D, Katsarou A, Armenaka M, Rigopoulos D, Zapanti M, Stratigos I. Influence of the menstrual cycle on skin-prick test reactions to histamine, morphine and allergen. Clin Exp Allergy 1995; 25: 461-466.
24. 24 Bosse K, Ladebeck HE. [Cutaneous histamine reaction in correlation to the menstrual cycle]. Z Haut Geschlechtskr 1972; 47: 365-370.
25. 25 Bartelink ML, De Wit A, Wollersheim H, Theeuwes A, Thien T. Skin vascular reactivity in healthy subjects: influence of hormonal status. J Appl Physiol 1993; 74: 727-732.
26. 26 Grossmann M, Jamieson MJ, Kellogg DL Jr, et al. The effect of iontophoresis on the cutaneous vasculature: evidence for current-induced hyperemia. Microvasc Res 1995; 50: 444-452.
27. 27 Fagrell B. Dynamics of skin microcirculation in humans. J Cardiovasc Pharmacol 1985; 7: S53-S58.
28. 28 Wallace RM, Young JM. Temperature dependence of the binding of [3H]mepyramine and related compounds to the histamine H1 receptor. Mol Pharmacol 1983; 23: 60-66.
29. 29 Treherne JM, Young JM. Temperature dependence of the kinetics of the binding of [3H] (+)-N-methyl-4 methyldiphenhydramine to the histamine H1-receptor: comparison with the kinetics of [3H]-mepyramine. Br J Pharmacol 1988; 94: 811-822.
30. 30 Sercombe R, Verrecchia C, Philipson V, et al. Histamine-induced constriction and dilatation of rabbit middle cerebral arteries in vitro: role of the endothelium. Blood Vessels 1986; 23: 137-153.
31. 31 Lindblad LE, Ekenvall L, Klingstedt C. Neural regulation of vascular tone and cold induced vasoconstriction in human finger skin. J Autou Nerv Syst 1990; 30: 169-173.
32. 32 Pergola PE, Kellogg DL Jr, Johnson JM, Kosiba WA, Solomon DE. Role of sympathetic nerves in the vascular effects of local temperature in human forearm skin. Am J Physiol 1993; 265: H785-H792.
33. 33 Harker CT, Ousley PJ, Harris EJ, Edwards JM, Taylor LM, Porter JM. The effects of cooling on human saphenous vein reactivity to adrenergic agonists. J Vasc Surg 1990; 12: 45-49.
34. 34 Daly MJ, Humphrey JM, Stables R. Some in vitro and in vivo actions of the new histamine H2-rcceptor antagonist, ranitidine. Br J Pharmacol 1981; 72: 49-54.
35. 35 Sekiguchi H, Hamada K, Kobayashi F, Taga F, Uchida H. Pharmacological profiles of the new histamine H2-receptor antagonist N-ethyl-N'-[3 -[3-(piperidinomethyl) phenoxy] propyl] urea. Arzneimittelforschung 1993; 43: 129-133.
36. 36 Agut J, Sanchez JC, Sacristan A, Ortiz JA. Action of ebrotidine, ranitidine and cimetidine on the specific binding to histamine H1-and H2-receptors. Arzneimittelforschung 1997; 47: 447-449.
37. 37 de la Cuadra J, Teruel M, Teixido P, Roma J. Assessment of the wheal size and skin blood flow of the erythema induced by histamine and its modification with cetirizine and ebastine: a crossover, double-blind study. Dermatology 1994; 188: 131-134.
38. 38 Simons FE, McMillan JL, Simons KJ. A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects. J Allergy Clin Immunol 1990; 86: 540-547.
39. 39 Harvey RP, Schocket AL. The effect of H1 and H2 blockade on cutaneous histamine response in man. J Allergy Clin Immunol 1980; 65: 136-139.
40. 40 Klemp P, Staberg B, Agdal N, Munkvad IM. Successful treatment of cold angio-oedema by H2-antihistamine therapy. Acta Derm Venereol 1983; 63: 262-264.
41. 41 Singh G. H2 blockers in chronic urticaria. Int J Dermatol 1984; 23: 627-628.
42. 42 Sharpe GR, Shuster S. In dermographic urticaria H2 receptor antagonists have a small but therapeutically irrelevant additional effect compared with H1 antagonists alone. Br J Dermatol 1993; 129: 575-579.
43. 43 Farnam J, Grant JA, Guernsey BG, Jorizzo JL, Petrusa ER. Successful treatment of chronic idiopathic urticaria and angioedema with cimetidine alone. J Allergy Clin Immunol 1984; 73: 842-845.
44. 44 Woodward DF, Owen DA. Studies on histamine-induced cutaneous flare in the guinea pig. Agents Actions 1983; 13: 35-44.
45. 45 Cheng HC, Reavis OK Jr, Munro NL, Woodward JK. Cutaneous vascular histamine H1 and H2 receptors in the guinea-pig: the histamine skin wheal as a cutaneous vascular model. Arch Int Pharmacodyn Ther 1979; 240: 214-219.
46. 46 Darsow U, Ring J, Scharein E, Bromm B. Correlations between histamine-induced wheal, flare and itch. Arch Dermatol Res 1996; 288: 436-441.