A review of studies relating to thyroid hormone therapy in brain-dead organ donors

Frontiers in Bioscience

Volumn 14, Issue 10, 2009, Pages 3750-3770

  Cooper, David K C ^a   Novitzky, Dimitri ^b   Wicomb, Winston N ^c   Basker, Murali ^d   Rosendale, John D ^e   Kauffman, H Myron ^e  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

^c INFECTIOUS DISEASE RESEARCH INSTITUTE   (United States)

^d GEISINGER MEDICAL CENTER   (United States)

^e UNITED NETWORK FOR ORGAN SHARING   (United States)

Author keywords

Brain death; Cardiopulmonary bypass; Corticosteroids; Insulin; Organ donation; Review; Thyroid hormones; Triiodothyronine

Indexed keywords

LIOTHYRONINE;

ANIMAL; BRAIN DEATH; DONOR; HEART; HUMAN; KIDNEY; PATHOPHYSIOLOGY; REVIEW;

ANIMALS; BRAIN DEATH; HEART; HUMANS; KIDNEY; TISSUE DONORS; TRIIODOTHYRONINE;

EID: 63849171422     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2735/3486     Document Type: Article

References (172)

1. W. N. Wicomb, S. T. Boyd, D. K. C. Cooper, A. G. Rose and C. N. Barnard. Ex vivo functional evaluation of pig hearts subjected to 24 hours preservation by hypothermic perfusion. S Afr Med J 60:245-248(1981) (Pubitemid 11052274)
2. W. N. Wicomb, D. K. C Cooper and C. N. Barnard. Twenty-four hour preservation of the pig heart by a portable hypothermic perfusion system. Transplantation 34:246-250(1982) (Pubitemid 13253419)
3. W. N. Wicomb, D. K. C. Cooper, J. Hassoulas, A. G. Rose and C. N. Barnard. Orthotopic transplantation of the baboon heart after 20 to 24 hours' preservation by continuous hypothermic perfusion with an oxygenated hyperosmolar solution. J Thorac Cardiovasc Surg 83:133-140(1982) (Pubitemid 12209562)
4. D. K. C. Cooper, W. N. Wicomb, and C. N. Barnard. Storage of the donor heart by a portable hypothermic perfusion system: experimental development and clinical experience. J Heart Transplant 2:104-110(1983) (Pubitemid 13128547)
5. D. K. C. Cooper, W. N. Wicomb, A. G. Rose and C. N. Barnard. Orthotopic allotransplantation and autotransplantation of the baboon heart following twenty-four hours storage by a portable hypothermic perfusion system. Cryobiology 20:385-394(1983)
6. W. N. Wicomb, D. K. C. Cooper, D. Novitzky and C. N. Barnard. Cardiac transplantation following storage of the donor heart by a portable hypothermic perfusion system. Ann Thorac Surg 37:243-248(1984) (Pubitemid 14160430)
7. W. N. Wicomb, D. K. C. Cooper and D. Novitzky. An airlift pump device for low pressure perfusion storage of the isolated heart. Cryobiology 22:401-408(1985) (Pubitemid 16241367)
8. W. N. Wicomb, D. Novitzky, D. K. C. Cooper and A. G. Rose. Forty-eight hours hypothermic perfusion storage of pig and baboon hearts. J Surg Res 40:276-284(1986) (Pubitemid 16028093)
9. W. N. Wicomb, A. G. Rose, D. K. C. Cooper and D. Novitzky. Haemodynamic and myocardial histological and ultrastructural studies in baboons three to twenty seven months following autotransplantation of hearts stored by hypothermic perfusion for 24 or 48 hours. J Heart Transplant 5:122-129(1986) (Pubitemid 17037499)
10. D. K. C. Cooper, W. N. Wicomb and D. Novitzky. Cardiac transplantation following storage of the donor heart by a portable hypothermic perfusion system: the initial clinical experience. In: Terasaki, P. I. (Ed). Clinical Transplants, Terasaki Foundation Laboratory, Los Angeles (2006)
11. C. N. Barnard and J. G. Losman. Left ventricular bypass. S Afr Med J 49:303-312(1975)
12. J. G. Losman, H. Levine, C. D. Campbell, R. L. Replogle, J. Hassoulas, D. Novitzky, D. K. C. Cooper and C. N. Barnard. Changes in indications for heart transplantation: an additional argument for the preservation of the recipient's own heart. J Thorac Cardiovasc Surg 84:716-726(1982) (Pubitemid 13096667)
13. D. Novitzky, D. K. C. Cooper and C. N. Barnard. The surgical technique of heterotopic heart transplantation. Ann Thorac Surg 36:476-482(1983) (Pubitemid 13015009)
14. D. K. C. Cooper, D. Novitzky, E. Becerra, and B. Reichart. Are there indications for heterotopic heart transplantation in 1986? A 2 to 11 year follow up of 49 consecutive patients undergoing heterotopic heart transplantation. The Thor Cardiovasc Surgeon 34:300-304(1986) (Pubitemid 16010728)
15. E. Becerra, D. K. C. Cooper, D. Novitzky and B. Reichart. Are there indications for heterotopic heart transplantation today? Transplant Proc 19:2512-2513(1987)
16. D. Novitzky, D. K. C. Cooper and C. N. Barnard. Reversal of acute rejection by cyclosporine in a heterotopic heart transplant. J Heart Transplant 3:117-120(1984) (Pubitemid 14129971)
17. D. Novitzky, D. K. C. Cooper, A. G. Rose and C. N. Barnard. The value of recipient heart assistance during severe acute rejection following heterotopic cardiac transplantation. J Cardiovasc Surg 25:287-295(1984) (Pubitemid 14002985)
18. D. Novitzky, D. K. C. Cooper and C. N. Barnard. Circulatory assistance with allograft. Ann Thorac Surg 37:2(1984)
19. D. K. C. Cooper, D. Novitzky, C. A. Romero, R. M. Clark, J. S. Chaffin, A. E. Greer, D. Novitzky, C. N. Barnard and N. Zuhdi. Indications for heterotopic heart transplantation, and report on two patients. J Okla State Med Assoc 81:513-517(1988)
20. H. Cushing. Some experimental and clinical observations concerning states of increased intracranial tension. Am J Med Sci 124:373-.400 (1902)
21. B. Shivalkar, J. Van Loon, W. Wieland, T. B. Tjandra-Maga, M. Borgers and C. Plets. Variable effects of explosive or gradual increase of intracranial pressure on myocardial structure and function. Circulation 87:230-239(1993) (Pubitemid 23019354)
22. H. Schrader, K. Krogness, A. Aakvaag, O. Sortland and K. Purvis. Changes of pituitary hormones in brain death. Acta Neurochir 52:239-248(1980). (Pubitemid 10060440)
23. G. M. Hall, K. Mashiter, J. Lumley and J. G. Robson. Hypothalamic- pituitary function in the 'brain-dead' patient. Lancet ii: 1259 (1980)
24. D. Novitzky, D. K. C. Cooper, A. G. Rose, W. N. Wicomb, E. Becerra and B. Reichart. Early donor heart failure following transplantation - the possible role of myocardial injury sustained during brain death. Clin Transplantation 1:108-113(1987)
25. D. Novitzky, J. Rhodin, D. K. C. Cooper, Y. Ye, K-W. Min and L. Debault. Ultrastructure changes associated with brain death in the human donor heart. Transplant Int 10:24-32(1997) (Pubitemid 26413387)
26. D. K. C. Cooper, J. C. De Villiers, L. S. Smith, Y. Crombie, S. T. Boyd, J. E. Jacobson and C. N. Barnard. Medical, legal and administrative aspects of cadaveric organ donation in the Republic of South Africa. S Afr Med J 62:933-938(1982) (Pubitemid 13168370)
27. D. Novitzky, W. N. Wicomb, D. K. C. Cooper, A. G. Rose, R. C. Fraser and C. N. Barnard. Electrocardiographic, haemodynamic and endocrine changes occurring during experimental brain death in the Chacma baboon. J Heart Transplant 4:63-69(1984) (Pubitemid 15123749)
28. D. Novitzky, A. Horak, D. K. C Cooper and A. G. Rose. Electrocardiographic and histopathologic changes developing during experimental brain death in the baboon. Transplant Proc 21:2567-2569(1989) (Pubitemid 19124462)
29. D. K. C. Cooper, D. Novitzky and W. N. Wicomb. The pathophysiological effects of brain death on potential donor organs, with particular reference to the heart. Ann R Coll Surg Engl 71:261-266(1989). (Pubitemid 19184474)
30. D. Novitzky, W. N. Wicomb, A. G. Rose, D. K. C. Cooper, and B. Reichart. Pathophysiology of pulmonary edema following experimental brain death in the Chacma baboon. Ann Thorac Surg 43:288-294(1987) (Pubitemid 17029534)
31. D. Novitzky, A. G. Rose, D. K. C. Cooper and B. Reichart. Interpretation of endomycordial biopsy after heart transplantation-potentially confusing factors. S Afr Med J 70; 789-792 (1986) (Pubitemid 17004779)
32. D. Novitzky, W. N. Wicomb, D. K. C. Cooper, A. G. Rose, R. C. Fraser and B. Reichart. Prevention of myocardial injury during brain death by total cardiac sympathectomy in the Chacma baboon. Ann Thorac Surg 41:520-524(1986) (Pubitemid 16114760)
33. D. Novitzky, D. K. C. Cooper, A. G. Rose and B. Reichart. Prevention of myocardial injury by pretreatment with verapamil hydrochloride following experimental brain death: efficacy in a baboon model. Am J Emerg Med 15:11-18(1987) (Pubitemid 17018264)
34. D. Novitzky, A. G. Rose and D. K. C. Cooper. Injury of myocardial conduction tissue and coronary artery smooth muscle following brain death in the baboon. Transplantation 45:964-966(1988)
35. J. Pratschke, M. J. Wilhelm, M. Kusaka, M. Basker, D. K. C. Cooper, W. W. Hancock and N. L. Tilney. Brain death and its influence on donor organ quality and outcome after transplantation. Transplantation 67:343-348(1999) (Pubitemid 29094001)
36. W. N. Wicomb, D. K. C. Cooper and D. Novitzky. Impairment of renal slice function following brain death, with reversibility of injury by hormonal therapy. Transplantation 41:29-33(1986) (Pubitemid 16186736)
37. W. N. Wicomb, D. K. C. Cooper, R. P. Lanza, D. Novitzky and S. Isaacs. The effects of brain death and 24 hours storage by hypothermic perfusion on donor heart function in the pig. J Thorac Cardiovasc Surg 91:896-909(1986) (Pubitemid 16092992)
38. D. Novitzky, D. K. C. Cooper, D. Morrell and S. Isaacs. Change from aerobic to anaerobic metabolism after brain death, and reversal following triiodothyronine (T3) therapy. Transplantation 45:32-36(1988) (Pubitemid 18084604)
39. D. Novitzky, W. N. Wicomb, D. K. C. Cooper and M. A. Tjaalgard. Improved cardiac function following hormonal therapy in brain dead pigs: relevance to organ donation. Cryobiology 24:1-10(1987) (Pubitemid 17012870)
40. D. Novitzky, D. K. C. Cooper and B. Reichart. Haemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors. Transplantation 43:852-854(1987) (Pubitemid 17084263)
41. D. Novitzky. Heart transplantation, euthyroid sick syndrome, and triiodothyronine replacement. J Heart Lung Transplant 11:196-198(1992)
42. D. R. Wheeldon, C. D. O. Potter, A. Oduro, J. Wallwork and S. R. Large. Transforming the "unacceptable" donor: outcomes from the adoption of a standardized donor management technique. J Heart Lung Transplant 14:734-742(1995)
43. V. Jeevanandam, B. Todd, T. Regillo, S. Hellman, C. Eldridge, and J. McClurken. Reversal of donor myocardial dysfunction by triiodothyronine replacement therapy. J Heart Lung Transplant 12:681-687(1994) (Pubitemid 24249611)
44. V. Jeevanandam. Triiodothyronine: spectrum of use in heart transplantation. Thyroid 7:139-145(1997) (Pubitemid 27132908)
45. A. Salim, P. Vassiliu, G. C. Velmahos, J. Sava, J. A. Murray, H. Belzberg, J. A. Asensio and D. Demetriades. The role of thyroid hormone administration in potential organ donors. Arch Surg 136:1377-1380(2001) (Pubitemid 33117043)
46. A. F. Zuppa, V. Nadkarni, L. Davis, P. C. Adamson, M. A. Helfaer, M. R. Elliott, J. Abrams and D. Durbin. The effect of a thyroid hormone infusion on vasopressor support in critically ill children with cessation of neurologic function. Crit Care Med 32:2318-2322(2004) (Pubitemid 39491815)
47. D. J. Powner, A. Hendrich, R. G. Lagler, R. H. Ng and R. L. Madden. Hormonal changes in brain dead patients. Crit Care Med 18:702-708(1990) (Pubitemid 20216233)
48. H-J. Gramm, H. Meinhold, U. Bickel, J. Zimmermann, B. Hammerstein, F. Keller, R. Dennhardt and K. Voigt. Acute endocrine failure after brain death? Transplantation 54:851-857(1992)
49. T. Randell and K. A. Hockerstedt. Triiodothyronine treatment in brain-dead multiorgan donors-a controlled study. Transplantation 54:736-738(1992)
50. J. P. Goarin, S. Cohen, B. Riou, Y. Jacquens, R. Guesde, F. LeBret, A. Aurengo and P. Coriat. The effect of triiodothyronine on hemodynamic status and cardiac function in potential heart donors. Anesth Analg 83:41-47(1996) (Pubitemid 26225372)
51. B. M. Power and P. V. Van Heerden. The physiological changes associated with brain death-current concepts and implications for treatment of the brain dead organ donor. Anesth Intensive Care 23:26-36(1995)
52. P. M. Mertes, K. E. Abassi, Y. Jaboin, P. Burtin, G. Pinelli, J. P. Carteaux, C. Burlet, M. Boulange and J. P. Villemot. Changes in hemodynamic and metabolic parameters following induced brain death in the pig. Transplantation 58:414-418(1994) (Pubitemid 24271527)
53. B. Lagiewska, M. Pacholczyk, M. Szostek, J. Walaszewski and W. Rowinski. Hemodynamic and metabolic disturbances observed in brain-dead organ donors. Transplant Proc 28:165-166(1996) (Pubitemid 26073683)
54. M. Szostek, Z. Gaciong, R. Danielelelewicz, B. Lagiewska, M. Pacholczky, A. Chmura, I. Laskowski, J. Walaszewski and W. Rowinski. Influence of thyroid function in brain stem death donors on kidney allograft function. Transplant Proc 29:3354-3356(1997) (Pubitemid 28008506)
55. H. Pienaar, I. Schwartz, A. Roncone, Z. Lotz and R. Hickman. Function of kidney grafts from brain-dead donor pigs. Transplantation 50:580-582(1990)
56. F. Masson, M. Thicoipe, H. Gin, A. Mascarel, R. M. Angibeau, J-F. Favarel-Garrigues and P. Erny. The endocrine pancreas in brain-dead donors. Transplantation 56:363-367(1993)
57. J. Harms, F-E. Isemer and H. Kolenda. Hormonal alteration and pituitary function during course of brainstem death in potential organ donors. Transplant Proc 23:2614-2616(1991)
58. I. E. Sazontseva, I. A. Kozlov, Y. G. Moisuc, A. E. Ermolenko, V. V. Afonin and V. V. Ilnitskiy. Hormonal response to brain death. Transplant Proc 23:2467(1991)
59. J. Mariot, L-O. Sadoune, F. Jacob, B. Dousset, J. F. Perrier, C. Jacob, P. Strub and C. Voltz. Hormone levels, hemodynamics and metabolism in brain-dead organ donors. Transplant Proc 27:793-794(1995)
60. J. J. Colpart, S. Ramella, M. Bret, B. Coronel, D. Dorez, A. Mercatello, A. H. Aissa and J. F. Moskovtchenko. Hypophysis-thyroid axis disturbances in human brain-dead donors. Transplant Proc 28:171-172(1996) (Pubitemid 26073686)
61. J. A. Macoviak, I. R. McDougall, M. F. Bayer, M. Brown, H. Tazelaar and E. B. Stinson. Significance of thyroid dysfunction in human cardiac allograft procurement. Transplantation 43:824-826(1987) (Pubitemid 17084257)
62. H. Yoshida, A. Hiraide, A. Iwai, N. Kawaguchi, T. Yoshioka and T. Sugimoto. Preservation of pancreatic endocrine function by hemodynamic stabilization following brain death. Clin Transplant 11:420-425(1997) (Pubitemid 27460438)
63. G. Szabo, C. Sebening, T. Hackert, C. Hagl, U. Tochermann, C. F. Vahl and S. Hagl. Effects of brain death on myocardial function and ischemic tolerance of potential donor hearts. J Heart Lung Transplant 17:921-930(1998) (Pubitemid 28440856)
64. G. Baroldi, G. Di Pasquale, M. D. Silver, G. Pinelli, A. M. Lusa, and V. Fineschi. Type and extent of myocardial injury related to brain damage and its significance in heart transplantation: a morphometric study. J Heart Lung Transplant 16:994-1000(1997) (Pubitemid 27465454)
65. J. A. Amado, F. Lopez-Espadas, A. Vazquez-Barquero, E. Salas, J. A. Riancho, J. J. Lopez-Cordovilla and M. T. Garcia-Unzueta. Blood levels of cytokines in brain-dead patients: relationship with circulating hormones and acutephase reactants. Metabolism 44:812-816(1995)
66. H. J. Gramm, J. Zimmermann, H. Meinhold, R. Dennhardt and K. Voigt. Hemodynamic responses to noxious stimuli in brain-dead organ donors. Intensive Care Med 18:493-495(1992) (Pubitemid 23027452)
67. M. Washida, R. Okamoto, D. Manaka, T. Yokoyama, Y. Yamamotom, K. Ino, N. Yamamoto, N. Osaki, Y. Shimahara, Y. Yamaoka, K. Kumada and K. Ozawa. Beneficial effect of combined 3, 5, 3'-triiodothyronine and vasopressin administration on hepatic energy status and systemic hemodynamics after brain death. Transplantation 54:44-49(1992)
68. J. Link, R. Rohling, and H. J. Gramm. Preservation of homeostasis following the onset of brain death. Anaesthesiol Reanim 4:249-260(1990)
69. J. Mariot, F. Jacob, C. Voltz, J. F. Perrier, and P. Strub. Value of hormonal treatment with triiodothyronine and cortisone in brain dead patients. Ann Fr Anesth Reanin 4:321-328(1991)
70. G. J. B. B. Bruinsma, M. G. J. Nederhoff, B. C. M. te Boekhorst, J. J. Bredee, T. J. C. Ruigrok and C. J. A. van Echteld. Brain death-induced alterations in myocardial workload and high-energy phosphates: a phosporus 31 magnetic resonance spectroscopy study in the cat. J Heart Lung Transplant 17:984-990(1998) (Pubitemid 28499028)
71. M. Galinanes and D. J. Hearse. Brain death-induced contractile dysfunction and long-term cardiac preservation. Circulation 88:270-280(1993)
72. H. B. Bittner, S. W. H Kendall, E. P. Chen and P. VanTrigt. The combined effects of brain death and cardiac graft preservation and cardiopulmonary hemodynamics and function before and subsequent heart transplantation. J Heart Lung Transplant 15:764-777(1996) (Pubitemid 26295296)
73. D. Tixier, G. Matheis, G. D. Buckberg, and H. H. Young. Donor hearts with impaired hemodynamics. Benefit of warm substrate-enriched blood cardioplegic solution for induction of cardioplegia during cardiac harvesting. J Thoracic Cardiovasc Surg 102:207-213(1991)
74. S. Darracott-Cankovic, J. Hutter, J. Wallwork, D. Wheeldon and T. A. English. Biopsy assessment of myocardial preservation in 160 human donor hearts. Transplant Proc 20(5, Suppl 7):44-48 (1988). (Pubitemid 18261402)
75. H. B. Bittner, E. P. Chen, C. A. Milano, S. W. Kendall, R. B. Jennings, D. C. Sabiston and P. Van Trigt. Myocardial β-adrenergic receptor function and high-energy phosphates in brain death-related cardiac dysfunction. Circulation 92 (9 suppl): II472-II478 (1995)
76. S. Darracott-Cankovic, P. G. Stovin, D. Wheeldon, J. Wallwork, F. Wells and T. A. English. Effect of donor heart damage on survival after transplantation. Eur J Cardiothorac Surg 3:525-532(1989)
77. M. Galinanes and D. J. Hearse. Brain-death induced cardiac contractile dysfunction: studies of possible neurohormonal and blood-borne mediators. J Mol Cell Cardiol 26:481-498(1994) (Pubitemid 24201412)
78. B. Riou, S. Dreux, S. Roche, M. Arthaud, J. P. Goarin, P. Leger, M. Saada and P. Viars. Circulating cardiac troponin T in potential heart transplant donors. Circulation 92:409-414(1995)
79. T. Kiitai, A. Tanaka, M. Terasaki, R. Okamoto, K. Ozawa, S. Morikawa and T. Inubushi. Energy metabolism of the heart and the liver in brain-dead dogs as assessed by 31P NMR spectroscopy. J Surg Res 55:599-606(1993) (Pubitemid 24003065)
80. G. Pinelli, P. M. Mertes, J. P. Carteaux, Y. Jaboin and J. P. Villemot. Consequences of brain death of myocardial metabolism: experimental study using 31P-nuclear magnetic resonance spectroscopy. Transplant Proc 27:1650-1651(1995)
81. G. Pinelli, P. M. Mertes, J. P. Carteaux Y. Jaboin, J. M. Escanye, F. Brunotte and J. P. Villemot. Myocardial effects of experimental acute brain death: evaluation by hemodynamic and biological studies. Ann Thorac Surg 60:1729-1734(1995) (Pubitemid 26078263)
82. S. Taniguchi, S. Kitamura, K. Kawachi, Y. Doi and N. Aoyama. Effects of hormonal supplements on the maintenance of cardiac function in potential donor patients after cerebral death. Eur J CardioThorac Surg 6:96-102(1992)
83. V. Jeevanandam, B. Todd, S. Hellman, C. Eldridge, J. McClurken and V. P. Addonizio. Use of triiodothyronine replacement therapy to reverse donor myocardial dysfunction: creating a larger donor pool. Transplant Proc 25:3305-3306(1993) (Pubitemid 24007330)
84. C. Sebening, C. Hagl, G. Szabo, U. Tochtermann, G. Strobel, P. Schnabel, K. Amann, C. F. Vahl and S. Hagl. Cardiocirculatory effects of acutely increased intracranial pressure and subsequent brain death. Eur J Cardiothorac Surg 9:360-372(1995)
85. C. H. Meyers, T. A. D'Amico. D. S. Peterseim, A. M. Jayawant, C. Steenbergen, D. C. Sabiston, and P. Van Trigt. Effects of triiodothyronine and vasopressin on cardiac function and myocardial blood flow after brain death. J Heart Lung Transplant 2:68-80(1993) (Pubitemid 23099862)
86. T. S. Huber, M. A. Groh, K. P. Gallagher and L. G. D'Alecy. Myocardial contractility in a canine model of the brain-dead organ donor. Crit Care Med 21:1731-1739(1993) (Pubitemid 23332093)
87. H. B. Bittner, S. W. H. Kendall, E. P. Chen, R. D. Davis and P. Van Tright. Myocardial performance after graft preservation and subsequent cardiac transplantation from brain dead donors. Ann Thorac Surg 60:47-54(1995)
88. M. Galinanes and D. J. Hearse. Brain death-induced impairment of cardiac contractile performance can be reversed by explantation and may not preclude the use of hearts for transplantation. Circ Res 71:1213-1219(1992)
89. G. J. Bruinsma, M. G. Nederhoff, H. J. Geertman, A. C. van Huffelen, P. J. Slootweg, R. Ferrari, M. Galinanes, D. J. Hearse, J. J. Bredee and T. J. Ruigrok. Acute increase of myocardial workload, hemodynamic instability and myocardial histologic changes induced by brain death in the cat. J Surg Res 68:7-15(1997) (Pubitemid 27187993)
90. T. A. D'Amico, D. A. Schwinn, C. H. Meyers, D. C. Sabiston and P. Van Trigt. Desentization of myocardial β-adrenergic receptors after brain death. Surg Forum 43:249-251(1992)
91. H. B. Bittner, S. W. H. Kendall, K. A. Campbell, T. J. Montine and P. Van Tright. A valid experimental brain death organ donor model. J Heart Lung Transplant 14:308-317, (1995)
92. T. T. Randell and K. A. V. Hockerstedt. Triiodothyronine treatment is not indicated in brain dead multiorgan donors: a controlled study. Transplant Proc 25:1552-1553(1993) (Pubitemid 23079097)
93. S. H. Pennefather and R. E. Bullock. Triiodothyronine treatment in brain dead multiorgan donors-a controlled study. Transplantation 55:1443(1993) (Pubitemid 23183271)
94. Y. Kinoshita, K. Okamoto, K. Yahata, T. Yosioka, T. Sugimoto, N. Kawaguch and S. Onishi. Clinical and pathophysiological changes of the heart in brain death maintained with vasopressin and epinephrine. Path Res Pract 186:173-179(1990) (Pubitemid 20097963)
95. H. Van Houten, H. G. Gooszen, P. J. van den Akker, H. H. Lemkes, M. Frolich, M. Van Gurp, F. J. van der Woude, J. Rischen-Vos and J. L. Terpstra. Plasma insulin, C-peptide, HbAlc, plasma glucose levels in organ donors. Transplant Proc 22:435-436(1990) (Pubitemid 20160421)
96. A. Iwai, T. Sakano, M. Uenishi, H. Sugimoto, T. Yoshioka and T. Sugimoto. Effect of vasopressin and catecholamines on the maintenance of circulatory stability in brain-dead patients. Transplantation 48:613-617(1989) (Pubitemid 19267480)
97. P. F. Gores, A. Viste, U. J. Hesse, K. C. Moudry-Munns, D. L. Dunn and D. E. Sutherland. The influence of donor hyperglycemia and other factors on long-term pancreatic allograft survival. Transplant Proc 22:437-438(1990) (Pubitemid 20160422)
98. U. J. Hess, P. F. Gores and D. E. R. Sutherland. Serum amylase and plasma glucose levels in pancreas cadaver donor: correlation with functional status of the pancreatic graft. Transplant Proc 21:2765(1989)
99. H. Yoshida, A. Hiraide, T. Yoshioka and T. Sugimoto. Transient suppression of pancreatic endocrine function in patients following brain death. Clin Transplant 10:28-33(1996)
100. K. Okamoto, Y. Kinoshita, T. Yushioka, N. Kawaguchi, S. Onishi and T. Sugimoto. Myocardial preservation in brain-dead patients maintained with vasopressin and catecholamine. Clin Transplant 6:294-300(1992)
101. T. Nagareda, Y. Kinoshita, A. Tanaka, M. Takeda, T. Sakano, K. Yawata, T. Sugimoto, Y. Nishizawa and N. Terada. Clinicopathology of kidneys from brain-dead patients treated with vasopressin and epinephrine. Kidney Int 43:1363-1370(1993) (Pubitemid 23161426)
102. T. Yoshioka, H. Sugimoto, M. Uenishi, T. Sakamoto, D. Sadamitsu, T. Sakano and T. Sugimoto. Prolonged hemodynamic maintanence by the combined administration of vasopressin and epinephrine in brain death: clinical study. Neurosurgery 18:565-567(1986) (Pubitemid 16076299)
103. T. Nagareda, Y. Kinoshita, A. Tanaka, Y. Hasuike, N. Terada, Y. Nishizawa, M. Fujita, H. Kuroda, K. Yawata, K. Aozasa, T. Sakano, T. Sugimoto and K. Kotoh. Clinicopathological study of livers from brain-dead patients treated with a combination of vasopressin and epinephrine. Transplantation 47:792-797(1989) (Pubitemid 19139115)
104. T. A. Howlett, A. M. Keogh, A. Perry, R. Touzel and L. H. Rees. Anterior and posterior pituitary function in brain-stem-dead donors. A possible role for hormonal replacement therapy. Transplantation 47:828-834(1989) (Pubitemid 19139122)
105. Y. Kinoshita, K. Yahata, T. Yoshioka, S. Onishi and T. Sugimoto. Long-term renal preservation after brain death maintained with vasopressin and epinephrine. Transplant Int 3:15-18(1990) (Pubitemid 20203145)
106. E. Arbustini, R. Pozzi, M. Grasso, C. Campana, A. Martinelli, C. Montemartini, A. Gavazzi, A. Pucci, M. Diegoli, G. Graziano, C. Goggi and M. Vigano. Endomyocardial biopsy of normal donor hearts before cardiac transplantation. A morphological and morphometrical study in 97 cases. Am J Cardiovasc Pathol 4:1-8(1992)
107. K. Arita, T. Uozumi, S. Oki, M. Ohtani, H. Taguchi and M. Morio. Hypothalamic pituitary function in brain death patients - from blood pituitary hormones and hypothalamic hormones. Neurol Surg (Tokyo) 16:1163-1171(1988)
108. T. Aruga, K. Ono, N. Kawahara, M. Sasaki, H. Tsutsumi, H. Toyooka, K. Mii, M. Tsuzuki and K. Takakura. Some practical problems of clinical diagnosis of brain death. Brain and Nerve (Tokyo) 35:777-785(1983) (Pubitemid 13051279)
109. P. Herinjgers, V. Leunens, T. B. Tjandra-Maga, K. Mubagwa and W. Flameng. Changes in organ perfusion after brain death in the rat and its relation to circulating catecholamines. Transplantation 62:330-335(1996) (Pubitemid 26277337)
110. D. Powner, A. Hendrich, A. Nyhuis and R. Strate. Changes in serum catecholamine levels in patients who are brain dead. J Heart Lung Transplant 11:1046-105(1992)
111. I. Finkelstein, L. H. Toledo-Pereyra and J. Castellanos. Physiologic and hormonal changes in experimentally induced brain dead dogs. Transplant Proc 19:4156(1987)
112. F. Masson, M. Thicoipe, M. J. Latapie MJ and P. Maurette. Thyroid function in brain-dead donors. Transplant Int 3:226-233(1990)
113. J. Harms, F-E. Isemer and H. Kolenda. Hormonal alteration and pituitary function during course of brainstem death in potential organ donors. Transplantation 56:363, (1993)
114. K. Arita, T. Uozumi, S. Oki, M. Ohtani and T. Mikami. The function of the hypothalamo-pituitary axis in the brain dead patients. Acta Neurochir 123:64-75(1993) (Pubitemid 23240675)
115. D. H. Fiser, J. Jimenez, V. Wrape and r. Woody. Diabetes insipidus in children with brain death. Crit Care Med 15:551-553(1987) (Pubitemid 17094091)
116. T. Sugimoto, T. Sakano, Y. Konoshita, M. Masui and T. Yoshioka. Morphological and functional alterations of the hypothalamic-pituitary system in brain death with long term bodily living. Acta Neurochir 115:31-36(1992)
117. P. M. Mertes, P. Burtin, J. P. Carteaux, Y. Jaboin, C. Dopff, G. Pinelli, J. P. Villemot, C. Burlet and M. Boulange. Brain death and myocardial injury: role of cardiac sympathetic innervation evaluated by in vivo interstitial microdialysis. Transplant Proc 26:231-232(1994) (Pubitemid 24080494)
118. K. M. Outwater and M. A. Rockoff. Diabetes insipidus accompanying brain death in children. Neurology 34:1243-1246(1984) (Pubitemid 14068602)
119. K. M. Robertson, I. M. Hramiak and A. W. Gelb. Endocrine changes and hemodynamic stability after brain death. Transplant Proc 21:1197-1198(1989) (Pubitemid 19130800)
120. E. M. Blaine, R. D. Tallman, D. Frolicher, M. A Jordan, L. L. Bluth and M. B. Howie. Vasopressin supplementation in a porcine model of brain-dead potential organ donors. Transplantation 38:459-464(1984) (Pubitemid 15207397)
121. J. P. Orlowski and E. K. Spees. Improved cardiac transplant survival with thyroxine treatment of hemodynamically unstable donors: 95.2% graft survival at 6 and 20 months. Transplant Proc 25:1535(1993) (Pubitemid 23079090)
122. T. Timek, A. Bonz, R. Dillmann, C. F. Vahl and S. Hagl. The effect of triiodothyronine on myocardial contractile performance after epinephrine exposure: implications for donor heart management. J Heart Lung Transplant 17:931-940(1998) (Pubitemid 28440857)
123. A. Salim, M. Martin, C. Brown, K. Inaba, B. Roth, P Hadjizacharia, A. Mascharenhas, P. Rhee and D. Demetriades. Using the thyroid hormone in brain-dead donors to maximize the number of organs available for transplantation. Clin Transplant 21:405-409(2007) (Pubitemid 46711405)
124. A. Salim, G. C. Velmahos, C. Brown, H. Belzberg and D. Demetriades. Aggressive organ donor management significantly increases the number of organs available for transplantation. J Trauma 58:991-994(2005) (Pubitemid 40776905)
125. L. C. Garcia-Fages, M. Antolin, C. Cabrer, R. Talbot, A. Alcaraz, F. Lozano and M. Manyalich. Effects of substitute triiodothyronine therapy on intracellular nucleotide levels in donor organs. Transplant Proc 23:2495-2496(1991)
126. K. Karayalcin, J. P. Umana, J. D. Harrison, J. A. Buckels, P. McMaster, and A. D. Mayer. Donor thyroid function does not affect outcome in orthotopic liver transplantation. Transplantation 57:669-672(1994) (Pubitemid 24106763)
127. T. Walhers, H. G. Fieguth, M. Jurmann, et al. Does hormone depletion of organ donors impair myocardial function after cardiac transplantation? Transplant Proc 20:792(1988)
128. 4 for managing hemodynamically recovery systems. Transplant Management 2:13. (1990)
129. J. P. Orlowski. Evidence that thyroxine (T4) is effective as a hemodynamic rescue agent in management of organ donors. Transplantation 55:959-960(1993) (Pubitemid 23122080)
130. A. Perez-Blanco, J. Caturla-Such, J. Canovas-Robles and J. Sanchez-Paya. Efficiency of triiodothyronine treatment on organ donor hemodynamic management and adenine nucleotide concentration. Intensive Care Med 31:943-948(2005) (Pubitemid 40941726)
131. H. Schrader, K. Krogness, A. Aakvaag, O. Sortland and K. Purvis. Changes of pituitary hormones in brain death. Acta Neurochir (Wien) 52:239-248(1980) (Pubitemid 10060440)
132. A. J. Hing, M. Hicks, S. R. Garlick, L. Gao, S. H. Kesteven, S. C. Faddy, M. K. Wilson, M. P. Feneley and P. S. Macdonald. The effects of hormone resuscitation on cardiac function and hemodynamics in a porcine brain-dead organ donor model. Am J Transplant 7:809-817(2007) (Pubitemid 46481210)
133. C. Seguin, Y. Devaux, S. Grosjean, E. M. Sighy, P. Mairose, F. Zannad, N. deTalance, D. Ungureanu-Longrois and P. M. Mertes. Evidence of cuntional myocardial ischemia associated with myocardial dysfunction in brain-dead pigs. Circulation 104 [12 Suppl 1]: I197-I201 (2001) (Pubitemid 32884802)
134. M. J. Wilhelm, J. Pratschke, I. A. Laskowski, D. M. Paz and N. L. Tilney. Brain death and its impact on the donor heart-lessons from animal models. J Heart Lung Transplant 19:414-418(2000) (Pubitemid 30249078)
135. R. R. Gifford, A. S. Weaver, J. E. Burg, P. J. Romano, L. M. Demers and J. L. Pennock. Thyroid hormone levels in heart and kidney cadaver donors. J Heart Transplant 5:249-253(1986) (Pubitemid 17039811)
136. J. Pratsche, G. Kofla, M. J. Wilhelm, A. Vergopoulos, I. Laskowski, G. D. Shaw, S. G. Tullius, H. D. Volk, P. Neuhaus and N. L. Tilney. Improvements in early behavior of rat kidney allografts after treatment of the brain-dead donor. Ann Surg 234:732-740(2001) (Pubitemid 33117193)
137. M. Takada, K. C. Nadeau, W. W. Hancock, H. S. Mackenzie, G. D. Shaw, A. M. Waaga, A. Chandraker, M. H. Sayegh and N. L. Tilney. Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Transplantation 65:1533-1542(1998) (Pubitemid 28304585)
138. H. B. Bittner, E. P. Chen, D. Craid and P. Van Trigt. Preload-recruitable stroke work relationships and diastolic dysfunction in the brain-dead organ donor. Circulation 94 [9 Suppl]: II320-II325 (1996) (Pubitemid 26363997)
139. J. M. Lyons, J. M. Pearl, K. M. McLean, S. A. Akhter, C. J. Wagner, P. K. Pandalai and J. Y. Duffy. Glucocorticoid administration reduces cardiac dysfunction after brain death in pigs. J Heart Lung Transplant 24:2249-2254(2005) (Pubitemid 41814753)
140. J. B. Ryan, M. Hicks, J. R. Cropper, S. R. Garlick, S. H. Kesteven, M. K. Wilson, M. P. Feneley and P. S. Macdonald. Functional evidence of reversible ischaemic injury immediately after sympathetic storm associated with experimental brain death. J Heart Lung Transplant 22:922-928(2003) (Pubitemid 36945492)
141. T. A. D'Amico, C. H. Meyers, T. C. Koutlas, D. S. Peterseim, D. C. Sabiston, P. Van Trigt and D. A. Schwinn. Desensitization of myocardial beta-adrenergic receptors and deterioration of left ventricular function after brain death. J Thoracic Cardiovasc Surgery 110:746-751(1995)
142. P. Chiari, G. Hadour, P. Michel, V. Piriou, C. Rodrigues, C. Budat, M. Ovize, O. Jegaden, J. J. Lehot and R. Ferrara. Biphasic response after brain death induction: prominent part of catecholamines release in this phenomenon. J Heart Lung Transplant 19:675-682(2000) (Pubitemid 30621680)
143. E. P. Chen, H. B. Bittner, S. W. Kendall and P. Van Trigt. Hormonal and hemodynamic changes in a validated animal model of brain death. Crit Care Med 24:1352-1359(1996) (Pubitemid 26262410)
144. B. R. Rosengard, S. Feng, E. J. Alfrey, J. G. Zaroff, J. C. Emond, M. L. Henry, E. R. Garrity, J. P. Roberts, J. J. Wynn, R. A. Metzger, R. B. Freeman, F. K. Port, R. M. Merion, R. B. Love, R. W. Busuttil and F. L. Delmonico. Report of the Crystal City meeting to maximize the use of organs recovered from the cadaver donor. Am J Transplant 2:701-711(2002). (Pubitemid 36342613)
145. J. G. Zaroff, B. R. Rosengard, W. F. Armstrong, W. D. Babcock, A. D'Alessandro, G. W. Dec, N. M. Edwards, R. S. Higgins, V. Jeevanandum, M. Kauffman, J. K. Kirklin, S. R. Large, D. Marelli, T. S. Peterson, W. S. Ring, R. C. Robbins, S. D. Russell, D. O. Taylor, A. Van Bakel, J. Wallwork, and J. B. Young. Consensus Conference report: Maximizing use of organs recovered from the cadaver donor: cardiac recommendations, March 28-29, 2001, Crystal City, VA. Circulation 106:836-841(2002)
146. J. G. Zaroff, B. R. Rosengard, W. F. Armstrong, WD. Babcock, A. D'Alessandro, G. W. Dec, N. M. Edwards, R. S. Higgins, V. Jeevanandum, M. Kauffman, J. K. Kirklin, S. R. Large, D. Marelli, t.s. Peterson, W. S. Ring, R. C. robbins, S. D. Russell, D. O. Taylor, A. Van Bakel, J. Wallwork and J. B. Young. Maximizing use of organs recovered from the cadaver donor: cardiac recommendations. J Heart Lung Transplant 21:1153-1160, 2002. (Pubitemid 35300462)
147. J. D. Rosendale, F. L. Chabalewski. M. A. McBride, E. R. Garrity, B. R. Rosengard, F. L. Delmonico and H. M. Kaufmann. Increased transplanted organs from the use of a standardized donor management protocol. Am J Transplant 2:761-768(2002) (Pubitemid 36342619)
148. D. Novitzky, D. K. C. Cooper, J. D. Rosendale and H. M. Kauffman. Hormonal therapy of the brain-dead organ donor: experimental and clinical studies. Transplantation 82:1396-1401(2006) (Pubitemid 44967616)
149. J. D. Rosendale, H. M. Kauffman, M. A. McBride, F. L. Chabalewski, J. G. Zaroff, E. R. Garrity, F. L. Delmonico and B. R. Rosengard. Aggressive pharmacological donor management results in more transplanted organs. Transplantation 75:482-487(2003) (Pubitemid 36241143)
150. J. D. Rosendale, H. M. Kauffman, M. A. McBride, F. L. Chabalewski, J. G. Zaroff, E. R. Garrity, F. L. Delmonico and B. R. Rosengard. Hormonal resuscitation yields more transplanted hearts with improved early function. Transplantation 75:1336-1341(2003) (Pubitemid 36513044)
151. http://www.ccdt.ca/external/english/publications/organdonor-guidelines. pdf. Accessed 2/15/06.
152. W. F. Bremner. K. M. Taylor, S. Baird, J. E. Thomson, J. A. Thomson, J. G. Ratcliffe, T. D. Lawrie and W. H. Bain. Hypothalamo-pituitary thyroid axis function during cardiopulmomary bypass. J Thorac Cardiovasc Surg;75;392-399 (1978) (Pubitemid 8296654)
153. G. Robuschi, D. Medici, F. Fesani, G. Barboso, M. Montermini, L. D'Amato, E. Gardini, E. Borciani, E. Dall'Aglio, Salvi M. Cardiopulmonary bypass: a lot T4 and T3 syndrome with blunted thyrotropinin (TSH) response to thyrotropin-releasing hormone (TRH). Horm Res 23:151-158(1986) (Pubitemid 16164203)
154. D. Novitzky, P. A. Human and D. K. C. Cooper. Inotropic effect of triiodothyronine following myocardial ischaemia and cardiopulmonary bypass: an experimental study in pigs. Ann Thorac Surg 45:50-55(1988) (Pubitemid 18034669)
155. D. Novitzky, P. A. Human, and D. K. C. Cooper. Effect of triiodothyronine (T3) on myocardial high energy phosphates and lactate following ischemia and cardiopulmonary bypass - an experimental study in baboons. J Thorac Cardiovasc Surg 96:600-607(1988)
156. D. Novitzky, D. K. C. Cooper, and A. Swanepoel. Inotropic effect of triiodothyronine (T3) following myocardial ischemia and cardiopulmonary bypass: Initial experience in patients undergoing open heart surgery. Eur J Cardiothorac Surg 3:140-145(1989)
157. D. Novitzky and D. K. C. Cooper. Changes in triiodothyronine during cardiopulmonary bypass: a clinical problem? J Thorac. Cardiovasc Surg 100:465(1990) (Pubitemid 20282107)
158. D. Novitzky, D. K. C. Cooper, C. I., Barton, A. Greer, J. Chaffin, J. Grim and N. Zuhdi. Triiodothyroinine as an inotropic agent after open heart surgery. J Thorac Cardiovasc Surg 98; 972-978 (1989) (Pubitemid 19282995)
159. D. Novitzky, H. Fontanet, M. Snyder, N. Coblio, D. Smith and V. Parsonnet. Impact of triiodothyronine on the survival of high risk patients undergoing open heart surgery. Cardiology 87:509-515(1996) (Pubitemid 26329305)
160. C. M. Dyke, T. Yeh, J. D. Lehman, A. Abd-Elfattah, M. Ding, A. S. Wechsler and D. R. Salter. Triiodothyronine-enhanced left ventricular function after ischemic injury. Ann Thorac Surg 52:14-19(1991)
161. R. Clark. Cardiopulmonary bypass and thyroid hormone metabolism. Ann Thorac Surg 56:35-42(1993)
162. E. Lowenstein. Implications of triiodothyronine administration before cardiac and noncardiac operations. Ann Thorac Surg 56:43-47(1993)
163. T. R. Snow, M. T. Deal, T. S. Connelly, Y. Yokoyama and D. Novitzky. Acute inotropic response of rabbit papillary muscle to triiodothyronine. Cardiology 80:112-117(1992)
164. P. J. Davis and F. B. Davis. Acute cellular action of thyroid hormone and myocardial function. Ann Thorac Surg 56:16-23(1993)
165. L. B. Gotzsche. Acute increase in cardiac performance after triiodothyronine: blunted response in amiodaronetreated pigs. J Cardiovasc Pharmacol 23:141-148(1994) (Pubitemid 24016855)
166. K. Sterling, P. O. Milvch, M. A. Brenner and J. H. Lazarus. Thyroid hormone action: the mitochondrial pathway. Science 197:996-999(1977) (Pubitemid 8166351)
167. D. Novitzky, D. K. C. Cooper, P. A. Human, B. Reichart and N. Zuhdi. Triiodothyronine therapy for heart donor and recipient. J Heart Transplant 7:370-376(1988)
168. D. Novitzky, D. K. C. Cooper, J. S. Chaffin, A. E. Greer, L. E. Debault and N. Zuhdi. Improved cardiac allograft function following triiodothyronine therapy to both donor and recipient. Transplantation 49:311-316(1990) (Pubitemid 20088167)
169. S. Taniguchi and D. K. C. D. K. C. Cooper. The potential role of thyroid hormone substitutes in cardiac surgery and transplantation. Asia Pacific J Thorac Cardiovasc Surg 5:40-46(1996) (Pubitemid 26260764)
170. D. Novitzky, N. Matthews, D. Shawley, D. K. C. Cooper and N. Zuhdi. Triiodothyronine in the recovery of stunned myocardium in dogs. Ann Thorac Surg 51:10-17(1991)
171. D. K. C. Cooper, D. Novitzky, and W. N. Wicomb. Hemodynamic and electrocardiographic responses. Transplant Proc, 20[5 Suppl 7]:25-28(1988) (Pubitemid 18261398)
172. D. Novitzky, D. K. C. Cooper, and N. Zuhdi. Triiodothyronine therapy in the cardiac transplant recipient. Transplant Proc, 20[5 Suppl 7]:65-68(1988) (Pubitemid 18261406)