Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: Effects on substrate binding, electron transfer, and uncoupling

Drug Metabolism and Disposition

Volumn 37, Issue 4, 2009, Pages 745-752

  Shebley, Mohamad ^a,b   Kent, Ute M ^a   Ballou, David P ^a   Hollenberg, Paul F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE; AMPHETAMINE DERIVATIVE; BENZPHETAMINE; CYTOCHROME P450 2B6; ETHYLBENZENE; HYDROGEN PEROXIDE; HYDROXYBENZPHETAMINE; METHAMPHETAMINE; PHENCYCLIDINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG EFFECT; DRUG HYDROXYLATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; ELECTRON TRANSPORT; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INACTIVATION; ENZYME SUBSTRATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIGAND BINDING; PRIORITY JOURNAL;

ARYL HYDROCARBON HYDROXYLASES; BENZPHETAMINE; CATALYSIS; CHROMATOGRAPHY, LIQUID; ELECTRON TRANSPORT; ENZYME INHIBITORS; OXIDOREDUCTASES, N-DEMETHYLATING; PHENCYCLIDINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SUBSTRATE SPECIFICITY;

EID: 63849160781     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.108.024661     Document Type: Article

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