Amygdala depotentiation ex vivo requires mitogen-activated protein kinases and protein synthesis

NeuroReport

Volumn 20, Issue 5, 2009, Pages 517-520

  Kim, Jeongyeon ^a   Park, Sungmo ^a   Lee, Sukwon ^a   Choi, Sukwoo ^a  

^a Seoul National University   (South Korea)

Author keywords

Depotentiation; Fear extinction; Mitogen activated kinase; NR2B containing NMDA receptors; Protein synthesis

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; CYCLOHEXIMIDE; IFENPRODIL; MITOGEN ACTIVATED PROTEIN KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; 1,3 BUTADIENE DERIVATIVE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ENZYME INHIBITOR; NITRILE; PIPERIDINE DERIVATIVE; PROTEIN SYNTHESIS INHIBITOR;

AMYGDALOID NUCLEUS; ARTICLE; ENZYME ACTIVITY; EX VIVO STUDY; FEAR; LEARNING; LONG TERM POTENTIATION; NERVE CELL INHIBITION; NERVE CELL PLASTICITY; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSTIMULATION; IN VITRO STUDY; LONG TERM DEPRESSION; MALE; METABOLISM; MICROELECTRODE; PHYSIOLOGY; RAT; REINFORCEMENT; SPRAGUE DAWLEY RAT;

ADRENERGIC ALPHA-ANTAGONISTS; AMYGDALA; ANIMALS; BUTADIENES; CYCLOHEXIMIDE; ELECTRIC STIMULATION; ENZYME INHIBITORS; EXTINCTION, PSYCHOLOGICAL; FEAR; LONG-TERM SYNAPTIC DEPRESSION; MALE; MICROELECTRODES; MITOGEN-ACTIVATED PROTEIN KINASES; NITRILES; PIPERIDINES; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 63849086116     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e328329412d     Document Type: Article

References (23)

1. Myers KM, Davis M. Behavioral and neural analysis of extinction. Neuron 2002; 36:567-584.
2. Maren S, Quirk GJ. Neuronal signaling of fear memory. Nat Rev Neurosci 2004; 5:844-852.
3. Lu KT, Walker DL, Davis M. Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear-potentiated startle. J Neurosci 2001; 21 (RC162):15.
4. Marsicano G, Wotjak CT, Azad SC, Bisogno T, Rammes G, Cascio MG, et al. The endogenous cannabinoid system controls extinction of aversive memories. Nature 2002; 418:530-534.
5. Lin CH, Yeh SH, Lu HY, Gean PW. The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory. J Neurosci 2003; 23:8310-8317.
6. Barad M, Gean PW, Lutz B. The role of the amygdala in the extinction of conditioned fear. Biol Psychiatry 2006; 60:322-328.
7. Herry C, Trifilieff P, Micheau J, Lüthi A, Mons N. Extinction of auditory fear conditioning requires MAPK/ERK activation in the basolateral amygdala. Eur J Neurosci 2006; 24:261-269.
8. Kim J, Lee S, Park H, Song B, Hong I, Geum D, et al. Blockade of amygdala metabotropic glutamate receptor subtype 1 impairs fear extinction. Biochem Biophys Res Commun 2007; 355:188-193.
9. Kim J, Lee S, Park K, Hong I, Song B, Son G, et al. Amygdala depotentiation and fear extinction. Proc Natl Acad Sci U S A 2007; 104:20955-20960.
10. Sotres-Bayon F, Bush DE, LeDoux JE. Acquisition of fear extinction requires activation of NR2B containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology 2007; 32:1929-1940.
11. Gutman AR, Yang Y, Ressler KJ, Davis M. The role of neuropeptide Y in the expression and extinction of fear-potentiated startle. J Neurosci 2008; 28:12682-12690.
12. Lee O, Lee CJ, Choi S. Induction mechanisms for L-LTP at thalamic input synapses to the lateral amygdala: requirement of mGluR5 activation. Neuroreport 2002; 13:685-691.
13. Huang YY, Martin KC, Kandel ER. Both protein kinase A, mitogen-activated protein kinase are required in the amygdala for the macromolecular synthesis-dependent late phase of long-term potentiation. J Neurosci 2000; 20:6317-6325.
14. Sajikumar S, Frey JU. Late-associativity, synaptic tagging, and the role of dopamine during LTP and LTD. Neurobiol Learn Mem 2004; 82:12-25.
15. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. San Diego: Academic; 1998.
16. Schafe GE, Atkins CM, Swank MW, Bauer EP, Sweatt JD, LeDoux JE. Activation of ERK/MAP kinase in the amygdala is required for memory consolidation of pavlovian fear conditioning. J Neurosci 2000; 20:8177-8187.
17. Bauer EP, Schafe GE, LeDoux JE. NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala. J Neurosci 2002; 22:5239-5249.
18. Li G, Nair SS, Quirk GJ. A biological realistic network model of acquisition and extinction of conditioned fear associations in lateral amygdala neurons. J Neurophysiol 2008; [in press].
19. Myers KM, Ressler KJ, Davis M. Different mechanisms of fear extinction dependent on length of time since fear acquisition. Learn Mem 2006; 13:216-223.
20. Royer S, Paré D. Bidirectional synaptic plasticity in intercalated amygdala neurons and the extinction of conditioned fear responses. Neuroscience 2002; 115:455-462.
21. Paré D, Quirk GJ, Ledoux JE. New vistas on amygdala networks in conditioned fear. J Neurophysiol 2004; 92:1-9.
22. Likhtik E, Popa D, Apergis-Schoute J, Fidacaro GA, Paré D. Amygdala intercalated neurons are required for expression of fear extinction. Nature 2008; 454:642-645.
23. Azad SC, Monory K, Marsicano G, Cravatt BF, Lutz B, Zieglgänsberger W, Rammes G. Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling. J Neurosci 2004; 24:9953-9961.