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Volumn 103, Issue 8, 2009, Pages 1107-1112

Combination Antiplatelet Therapy for Secondary Stroke Prevention: Enhanced Efficacy or Double Trouble?

Author keywords

[No Author keywords available]

Indexed keywords

ACENOCOUMAROL; ACETYLSALICYLIC ACID; ANTITHROMBOCYTIC AGENT; ANTIVITAMIN K; CLOPIDOGREL; DIPYRIDAMOLE; PHENPROCOUMON; PLACEBO; WARFARIN;

EID: 63749112292     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2009.01.003     Document Type: Review
Times cited : (43)

References (39)
  • 1
    • 0028062665 scopus 로고
    • History of drugs for thrombotic disease. Discovery, development, and directions for the future
    • Mueller R.L., and Scheidt S. History of drugs for thrombotic disease. Discovery, development, and directions for the future. Circulation 89 (1994) 432-449
    • (1994) Circulation , vol.89 , pp. 432-449
    • Mueller, R.L.1    Scheidt, S.2
  • 2
    • 0028120906 scopus 로고
    • Collaborative overview of randomized trials of antiplatelet therapy, I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients
    • Antiplatelet Trialists' Collaboration
    • Antiplatelet Trialists' Collaboration. Collaborative overview of randomized trials of antiplatelet therapy, I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. BMJ 308 (1994) 81-106
    • (1994) BMJ , vol.308 , pp. 81-106
  • 3
    • 45949109467 scopus 로고    scopus 로고
    • Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition)
    • American College of Chest Physicians
    • Albers G.W., Amarenco P., Easton J.D., Sacco R.L., Teal P., and American College of Chest Physicians. Antithrombotic and thrombolytic therapy for ischemic stroke: American College of Chest Physicians evidence-based clinical practice guidelines (8th edition). Chest 133 (2008) 630S-669S
    • (2008) Chest , vol.133
    • Albers, G.W.1    Amarenco, P.2    Easton, J.D.3    Sacco, R.L.4    Teal, P.5
  • 4
    • 33747599590 scopus 로고    scopus 로고
    • Adverse impact of bleeding on prognosis in patients with acute coronary syndromes
    • Eikelboom J.W., Mehta S.R., Anand S.S., Xie C., Fox K.A., and Yusuf S. Adverse impact of bleeding on prognosis in patients with acute coronary syndromes. Circulation 114 (2006) 774-782
    • (2006) Circulation , vol.114 , pp. 774-782
    • Eikelboom, J.W.1    Mehta, S.R.2    Anand, S.S.3    Xie, C.4    Fox, K.A.5    Yusuf, S.6
  • 5
    • 0032853392 scopus 로고    scopus 로고
    • Bleeding complications in secondary stroke prevention by antiplatelet therapy: a benefit-risk analysis
    • Boysen G. Bleeding complications in secondary stroke prevention by antiplatelet therapy: a benefit-risk analysis. J Intern Med 246 (1999) 239-245
    • (1999) J Intern Med , vol.246 , pp. 239-245
    • Boysen, G.1
  • 6
    • 0347416911 scopus 로고    scopus 로고
    • Risk of bleeding complications with antiplatelet agents: meta-analysis of 338,191 patients enrolled in 50 randomized controlled trials
    • Serebruany V.L., Malinin A.I., Eisert R.M., and Sane D.C. Risk of bleeding complications with antiplatelet agents: meta-analysis of 338,191 patients enrolled in 50 randomized controlled trials. Am J Hematol 75 (2004) 40-47
    • (2004) Am J Hematol , vol.75 , pp. 40-47
    • Serebruany, V.L.1    Malinin, A.I.2    Eisert, R.M.3    Sane, D.C.4
  • 7
    • 18144373789 scopus 로고    scopus 로고
    • Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials
    • Serebruany V.L., Steinhubl S.R., Berger P.B., Malinin A.I., Baggish J.S., Bhatt D.L., and Topol E.J. Analysis of risk of bleeding complications after different doses of aspirin in 192,036 patients enrolled in 31 randomized controlled trials. Am J Cardiol 95 (2005) 1218-1222
    • (2005) Am J Cardiol , vol.95 , pp. 1218-1222
    • Serebruany, V.L.1    Steinhubl, S.R.2    Berger, P.B.3    Malinin, A.I.4    Baggish, J.S.5    Bhatt, D.L.6    Topol, E.J.7
  • 9
    • 0025751563 scopus 로고
    • Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events
    • The SALT Collaborative Group
    • The SALT Collaborative Group. Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. Lancet 338 (1991) 1345-1349
    • (1991) Lancet , vol.338 , pp. 1345-1349
  • 10
    • 33744945247 scopus 로고    scopus 로고
    • Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE W): a randomised controlled trial
    • Connolly S., Pogue J., Hart R., Pfeffer M., Hohnloser S., Chrolavicius S., Pfeffer M., Hohnloser S., and Yusuf S. Clopidogrel plus aspirin versus oral anticoagulation for atrial fibrillation in the Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE W): a randomised controlled trial. Lancet 367 (2006) 1903-1912
    • (2006) Lancet , vol.367 , pp. 1903-1912
    • Connolly, S.1    Pogue, J.2    Hart, R.3    Pfeffer, M.4    Hohnloser, S.5    Chrolavicius, S.6    Pfeffer, M.7    Hohnloser, S.8    Yusuf, S.9
  • 11
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of Clopidogrel Versus Aspirin in Patients at Risk of Ischaemic Events (CAPRIE)
    • CAPRIE Steering Committee
    • CAPRIE Steering Committee. A randomised, blinded, trial of Clopidogrel Versus Aspirin in Patients at Risk of Ischaemic Events (CAPRIE). Lancet 348 (1996) 1329-1339
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 13
    • 3242770664 scopus 로고    scopus 로고
    • Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial
    • MATCH Investigators
    • Diener H.C., Bogousslavsky J., Brass L.M., Cimminiello C., Csiba L., Kaste M., Leys D., Matias-Guiu J., Rupprecht H.J., and MATCH Investigators. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet 364 (2004) 331-337
    • (2004) Lancet , vol.364 , pp. 331-337
    • Diener, H.C.1    Bogousslavsky, J.2    Brass, L.M.3    Cimminiello, C.4    Csiba, L.5    Kaste, M.6    Leys, D.7    Matias-Guiu, J.8    Rupprecht, H.J.9
  • 14
    • 0026355123 scopus 로고
    • The United Kingdom Transient Ischaemic Attack (UK-TIA) aspirin trial: final results
    • Farrell B., Godwin J., Richards S., and Warlow C. The United Kingdom Transient Ischaemic Attack (UK-TIA) aspirin trial: final results. J Neurol Neurosurg Psychiatry 54 (1991) 1044-1054
    • (1991) J Neurol Neurosurg Psychiatry , vol.54 , pp. 1044-1054
    • Farrell, B.1    Godwin, J.2    Richards, S.3    Warlow, C.4
  • 16
    • 0030297319 scopus 로고    scopus 로고
    • European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke
    • Diener H.C., Cunha L., Forbes C., Sivenius J., Smets P., and Lowenthal A. European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci 143 (1996) 1-13
    • (1996) J Neurol Sci , vol.143 , pp. 1-13
    • Diener, H.C.1    Cunha, L.2    Forbes, C.3    Sivenius, J.4    Smets, P.5    Lowenthal, A.6
  • 17
    • 0026072561 scopus 로고
    • A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke
    • The Dutch TIA Trial Study Group
    • The Dutch TIA Trial Study Group. A comparison of two doses of aspirin (30 mg vs. 283 mg a day) in patients after a transient ischemic attack or minor ischemic stroke. N Engl J Med 325 (1991) 1261-1266
    • (1991) N Engl J Med , vol.325 , pp. 1261-1266
  • 18
    • 33846230041 scopus 로고    scopus 로고
    • Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of arterial origin (ESPRIT): a randomised controlled trial
    • ESPRIT Study Group
    • Halkes P.H., van Gijn J., Kappelle L.J., Koudstaal P.J., Algra A., and ESPRIT Study Group. Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of arterial origin (ESPRIT): a randomised controlled trial. Lancet Neurol 6 (2007) 115-124
    • (2007) Lancet Neurol , vol.6 , pp. 115-124
    • Halkes, P.H.1    van Gijn, J.2    Kappelle, L.J.3    Koudstaal, P.J.4    Algra, A.5
  • 19
    • 33646596912 scopus 로고    scopus 로고
    • Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial
    • Halkes P.H., van Gijn J., Kappelle L.J., Koudstaal P.J., and Algra A. Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled trial. Lancet 367 (2006) 1665-1673
    • (2006) Lancet , vol.367 , pp. 1665-1673
    • Halkes, P.H.1    van Gijn, J.2    Kappelle, L.J.3    Koudstaal, P.J.4    Algra, A.5
  • 21
    • 0035072437 scopus 로고    scopus 로고
    • Prediction of hemorrhagic transformation following acute stroke: role of diffusion- and perfusion-weighted magnetic resonance imaging
    • Tong D.C., Adami A., Moseley M.E., and Marks M.P. Prediction of hemorrhagic transformation following acute stroke: role of diffusion- and perfusion-weighted magnetic resonance imaging. Arch Neurol 58 (2001) 587-593
    • (2001) Arch Neurol , vol.58 , pp. 587-593
    • Tong, D.C.1    Adami, A.2    Moseley, M.E.3    Marks, M.P.4
  • 22
    • 33645062709 scopus 로고    scopus 로고
    • Cerebral microhemorrhages predict new disabling or fatal strokes in patients with acute ischemic stroke or transient ischemic attack
    • VISION Study Group
    • Boulanger J.M., Coutts S.B., Eliasziw M., Gagnon A.J., Simon J.E., Subramaniam S., Sohn C.H., Scott J., Demchuk A.M., and VISION Study Group. Cerebral microhemorrhages predict new disabling or fatal strokes in patients with acute ischemic stroke or transient ischemic attack. Stroke 37 (2006) 911-914
    • (2006) Stroke , vol.37 , pp. 911-914
    • Boulanger, J.M.1    Coutts, S.B.2    Eliasziw, M.3    Gagnon, A.J.4    Simon, J.E.5    Subramaniam, S.6    Sohn, C.H.7    Scott, J.8    Demchuk, A.M.9
  • 23
    • 32844468673 scopus 로고    scopus 로고
    • Aspirin to prevent heart attack and stroke: what's the right dose?
    • Dalen J.E. Aspirin to prevent heart attack and stroke: what's the right dose?. Am J Med 119 (2006) 198-202
    • (2006) Am J Med , vol.119 , pp. 198-202
    • Dalen, J.E.1
  • 24
    • 34248352504 scopus 로고    scopus 로고
    • Aspirin dose for the prevention of cardiovascular disease: a systematic review
    • Campbell C.L., Smyth S., Montalescot G., and Steinhubl S.R. Aspirin dose for the prevention of cardiovascular disease: a systematic review. JAMA 297 (2007) 2018-2024
    • (2007) JAMA , vol.297 , pp. 2018-2024
    • Campbell, C.L.1    Smyth, S.2    Montalescot, G.3    Steinhubl, S.R.4
  • 25
    • 0019460557 scopus 로고
    • Differential inhibition by low-dose aspirin of human venous prostacyclin synthesis and platelet thromboxane synthesis
    • Hanley S.P., Bevan J., Cockbill S.R., and Heptinstall S. Differential inhibition by low-dose aspirin of human venous prostacyclin synthesis and platelet thromboxane synthesis. Lancet 1 (1981) 969-971
    • (1981) Lancet , vol.1 , pp. 969-971
    • Hanley, S.P.1    Bevan, J.2    Cockbill, S.R.3    Heptinstall, S.4
  • 26
  • 27
    • 0030894130 scopus 로고    scopus 로고
    • The case of low-dose aspirin for the prevention of myocardial infarction: but how low is low?
    • Forster W., and Parratt J.R. The case of low-dose aspirin for the prevention of myocardial infarction: but how low is low?. Cardiovasc Drugs Ther 10 (1997) 727-734
    • (1997) Cardiovasc Drugs Ther , vol.10 , pp. 727-734
    • Forster, W.1    Parratt, J.R.2
  • 28
    • 0032879820 scopus 로고    scopus 로고
    • Ticlopidine and clopidogrel
    • Quinn M.J., and Fitzgerald D.J. Ticlopidine and clopidogrel. Circulation 100 (1999) 1667-1672
    • (1999) Circulation , vol.100 , pp. 1667-1672
    • Quinn, M.J.1    Fitzgerald, D.J.2
  • 29
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study
    • Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial (CURE) Investigators
    • Mehta S.R., Yusuf S., Peters R.J., Bertrand M.E., Lewis B.S., Natarajan M.K., Malmberg K., Rupprecht H., Zhao F., Chrolavicius S., et al., Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial (CURE) Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 358 (2001) 527-533
    • (2001) Lancet , vol.358 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.3    Bertrand, M.E.4    Lewis, B.S.5    Natarajan, M.K.6    Malmberg, K.7    Rupprecht, H.8    Zhao, F.9    Chrolavicius, S.10
  • 30
    • 0035899289 scopus 로고    scopus 로고
    • Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation
    • Yusuf S., Zhao F., Mehta S.R., Chrolavicius S., Tognoni G., and Fox K.K. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med 345 (2001) 494-502
    • (2001) N Engl J Med , vol.345 , pp. 494-502
    • Yusuf, S.1    Zhao, F.2    Mehta, S.R.3    Chrolavicius, S.4    Tognoni, G.5    Fox, K.K.6
  • 31
    • 0037335810 scopus 로고    scopus 로고
    • Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies
    • Aktas B., Utz A., Hoenig-Liedl P., Walter U., and Geiger J. Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies. Stroke 34 (2003) 764-769
    • (2003) Stroke , vol.34 , pp. 764-769
    • Aktas, B.1    Utz, A.2    Hoenig-Liedl, P.3    Walter, U.4    Geiger, J.5
  • 32
    • 0033767132 scopus 로고    scopus 로고
    • Aggrenox: a fixed-dose combination of aspirin and dipyridamole
    • Lenz T.L., and Hilleman D.E. Aggrenox: a fixed-dose combination of aspirin and dipyridamole. Ann Pharmacother 34 (2000) 1283-1290
    • (2000) Ann Pharmacother , vol.34 , pp. 1283-1290
    • Lenz, T.L.1    Hilleman, D.E.2
  • 33
    • 0026795885 scopus 로고
    • S-nitroso-glutathione inhibits platelet activation in vitro and in vivo
    • Radomski M.W., Rees D.D., Dutra A., and Moncada S. S-nitroso-glutathione inhibits platelet activation in vitro and in vivo. Br J Pharmacol 107 (1992) 745-749
    • (1992) Br J Pharmacol , vol.107 , pp. 745-749
    • Radomski, M.W.1    Rees, D.D.2    Dutra, A.3    Moncada, S.4
  • 34
    • 0024553336 scopus 로고
    • Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells
    • Garg U.C., and Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest 83 (1989) 1774-1777
    • (1989) J Clin Invest , vol.83 , pp. 1774-1777
    • Garg, U.C.1    Hassid, A.2
  • 35
    • 0029741925 scopus 로고    scopus 로고
    • Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1
    • Tsao P.S., Buitrago R., Chan J.R., and Cooke J.P. Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1. Circulation 94 (1996) 1682-1689
    • (1996) Circulation , vol.94 , pp. 1682-1689
    • Tsao, P.S.1    Buitrago, R.2    Chan, J.R.3    Cooke, J.P.4
  • 36
    • 44049083884 scopus 로고    scopus 로고
    • Bleeding risks of combination vs. single antiplatelet therapy: a meta-analysis of 18 randomized trials comprising 129,314 patients
    • Serebruany V.L., Malinin A.I., Ferguson J.J., Vahabi J., Atar D., and Hennekens C.H. Bleeding risks of combination vs. single antiplatelet therapy: a meta-analysis of 18 randomized trials comprising 129,314 patients. Fundam Clin Pharmacol 22 (2008) 315-321
    • (2008) Fundam Clin Pharmacol , vol.22 , pp. 315-321
    • Serebruany, V.L.1    Malinin, A.I.2    Ferguson, J.J.3    Vahabi, J.4    Atar, D.5    Hennekens, C.H.6
  • 37
    • 0023864355 scopus 로고
    • Thrombolysis In Myocardial Infarction (TIMI) trial-phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase
    • Rao A.K., Pratt C., Berke A., Jaffe A., Ockene I., Schreiber T.L., Bell W.R., Knatterud G., Robertson T.L., and Terrin M.L. Thrombolysis In Myocardial Infarction (TIMI) trial-phase I: hemorrhagic manifestations and changes in plasma fibrinogen and the fibrinolytic system in patients treated with recombinant tissue plasminogen activator and streptokinase. J Am Coll Cardiol 11 (1988) 1-11
    • (1988) J Am Coll Cardiol , vol.11 , pp. 1-11
    • Rao, A.K.1    Pratt, C.2    Berke, A.3    Jaffe, A.4    Ockene, I.5    Schreiber, T.L.6    Bell, W.R.7    Knatterud, G.8    Robertson, T.L.9    Terrin, M.L.10
  • 38
    • 0027240597 scopus 로고
    • An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction
    • The GUSTO Investigators
    • The GUSTO Investigators. An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 329 (1993) 673-682
    • (1993) N Engl J Med , vol.329 , pp. 673-682
  • 39
    • 33846102236 scopus 로고    scopus 로고
    • Assessment of bleeding events in clinical trials-proposal of a new classification
    • Serebruany V.L., and Atar D. Assessment of bleeding events in clinical trials-proposal of a new classification. Am J Cardiol 99 (2007) 288-290
    • (2007) Am J Cardiol , vol.99 , pp. 288-290
    • Serebruany, V.L.1    Atar, D.2


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