Perspective: Prospective health care and the role of academic medicine: Lead, follow, or get out of the way

Academic Medicine

Volumn 83, Issue 8, 2008, Pages 707-714

  Snyderman, Ralph ^a,b   Yoediono, Ziggy ^b  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GOVERNMENT; HEALTH CARE DELIVERY; HEALTH CARE PLANNING; HEALTH CARE POLICY; HEALTH CARE SYSTEM; HEALTH INSURANCE; HUMAN; PATIENT PARTICIPATION; PREVENTIVE MEDICINE; PRIORITY JOURNAL; REIMBURSEMENT; REVIEW; STRATEGIC PLANNING; UNITED STATES;

ACADEMIC MEDICAL CENTERS; EDUCATION, MEDICAL; GENETIC PREDISPOSITION TO DISEASE; GENOMICS; HEALTH POLICY; HUMANS; PREVENTIVE HEALTH SERVICES; RISK ASSESSMENT; UNITED STATES;

EID: 63749089092     PISSN: 10402446     EISSN: None     Source Type: Journal    
DOI: 10.1097/ACM.0b013e31817ec800     Document Type: Review

References (67)

1. Snyderman R, Williams RS. Prospective medicine: The next health care transformation. Acad Med. 2003;78:1079-1084. (Pubitemid 37370340)
2. Association of American Medical Colleges. AAMC chair's address 2002: Prospective medicine: The next health care transformation [press release]. November 10, 2002. Available at: (http://www.aamc.org/newsroom/pressrel/2002/ 021111.htm). Accessed April 3, 2008.
3. Thorisson GA, Smith AV, Krishnan L, Stein LD. The International HapMap project Web site. Genome Res. 2005;15:1592-1593. (Pubitemid 41545013)
4. Zheng SL, Sun J, Wiklund F, et al. Cumulative association of five genetic variants with prostate cancer. N Engl J Med. 2008;358:1-10.
5. Antoniou AC, Easton DF. Models of genetic susceptibility to breast cancer. Oncogene. 2006;25:5898-5905. (Pubitemid 44453445)
6. Begg CB, Haile RW, Bork A, et al. Variation of breast cancer risk among BRCA1/2 carriers. JAMA. 2008;299:194-201.
7. Aithal GP, Day CP, Kesteven PJL, Daly AK. Association of polymorphisms in the cytochrome P450 CYP2C9 with warfarin dose requirement and risk of bleeding complications. Lancet. 1999;353:717-719.
8. U.S. Department of Health and Human Services. Personalized Health Care. Available at: (http://www.hhs.gov/myhealthcare). Accessed April 3, 2008.
9. National Cancer Institute and National Human Genome Research Institute. The Cancer Genome Atlas. Available at: (http://cancergenome.nih.gov). Accessed April 17, 2008.
10. Zerhouni EA. The NIH Roadmap. Science. 2003;302:63-72.
11. National Institutes of Health. The Biomarkers Consortium. Available at: (http:/www.biomarkersconsortium.org). Accessed April 3, 2008.
12. Zerhouni EA, Sanders CA, von Eschenbach AC. The Biomarkers Consortium: Public and private sectors working in partnership to improve the public health. Oncologist. 2007; 12:250-252.
13. Broad Institute. Clinical Proteomic Technology Assessment for Cancer (CPTAC) Program. Available at: (http://www.broad.mit.edu/proteomics/CPTAC/index. html). Accessed April 3, 2008.
14. Dressman HK, Berchuck A, Chan G, et al. An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer. J Clin Oncol. 2007;25:517-525. (Pubitemid 350002958)
15. Hood L, Heath JR, Phelps ME, Lin B. Systems biology and new technologies enable predictive and preventative medicine. Science. 2004;306:640-643. (Pubitemid 39440903)
16. Pujana MA, Han J-DJ, Starita LM, et al. Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 2007;39:1338-1349. (Pubitemid 350035000)
17. Pittman J, Huang E, Dressman H, et al. Integrated modeling of clinical and gene expression information for personalized prediction of disease outcomes. Proc Natl Acad Sci USA. 2004;101:8431-8436. (Pubitemid 38736592)
18. Lyman GH, Kuderer NM, Crawford J, et al. Prospective validation of a risk model for first cycle neutropenic complications in patients receiving cancer chemotherapy. 2006 ASCO Annual Meeting Proceedings Part I. J Clin Oncol. June 24, 2006;(18 suppl):8561.
19. CardioDx, Inc. Web site. Available at: (http://www.cardiodx.com). Accessed April 14, 2008.
20. Genomic Health, Inc. Web site. Available at: (http://www.genomichealth. com). Accessed April 14, 2008.
21. Millenium Pharmaceuticals, Inc. Web site. Available at: (http://www.mlnm.com). Accessed April 14, 2008.
22. SAS Institute Inc. Web site. Available at: (http://www.sas.com). Accessed April 14, 2008.
23. Proventys Inc. Web site. Available at: (http://proventys.com). Accessed April 14, 2008.
24. BioSignia Inc. Web site. Available at: (http://www.biosignia.com). Accessed July 5, 2007.
25. Dobbe E, Gurney K, Kiekow S, Lafferty JS, Kolesar JM. Gene-expression assays: New tools to individualize treatment of early stage breast cancer. Am J Health Syst Pharm. 2008; 65:23-28.
26. XDx products and services. Available at: (http://www.xdx.com/products/ps. htm). Accessed April 3, 2008.
27. Navigenics Inc. Web site. Available at: (http://www.navigenics.com). Accessed April 14, 2008.
28. 23andMe, Inc. Web site. Available at: (https://www. 23andme.com). Accessed April 14, 2008.
29. Biophysical health assessments. Available at: (http://www. biophysicalcorp.com/assessments/biophyscial250.aspx). Accessed April 3, 2008.
30. About Sciona. Available at: (http://www.sciona.com). Accessed April 3, 2008.
31. National Center for Research Resources. CTSA science awards. Available at: (http://www.ncrr.nih.gov/clinical-research-resources/clinical-and- translational-science-awards/). Accessed June 5, 2008.
32. Campbell CY, Nasir K, Blumenthal RS. Metabolic syndrome, subclinical coronary atherosclerosis, and cardiovascular risk. Am Heart Hosp J. 2005;3:105-110.
33. Euhus DM. Understanding mathematical models for breast cancer risk assessment and counseling. Breast J. 2001;7:223-232.
34. Yoediono Z, Snyderman R. Proposal for a new health record to support personalized, predictive, preventative and participatory medicine. Personalized Med. 2008;5:47-54.
35. Centers for Medicare and Medicaid Services. Personal Health Records overview. Available at: (http://www.cms.hhs.gov/PerHealthRecords). Accessed April 3, 2008.
36. WebMD Health Manager. Available at: (http://www.webmd.com/health-manager) . Accessed April 3, 2008.
37. PR Newswire. Verizon CEO announces implementation of new online personal health records program for company employees. Available at: (http://sev. prnewswire.com/telecommunications/20070509/NYW10309052007-l.html). Accessed June 5, 2008.
38. eWEEK. Large employers to provide online personal health records. Available at: (http://www.eweek.com/article2/0,1895,2069937,00.asp). Accessed April 3, 2008.
39. America's Health Insurance Plans. Innovations in Health Information Technology. Available at: (http://www.ahipresearch.org/pdfs/AHIP-InvHealthIT-05. pdf). Accessed April 3, 2008.
40. Aetna. Aetna introduces powerful, interactive personal record. Available at: (http://www.aetna.com/news/2006/pr-20061003.htm). Accessed April 3, 2008.
41. Google Health. About Google Health. Available at: (https://www.google. com/health/html/about/index.html). Accessed June 5, 2008.
42. Microsoft Health Vault. Available at: (http://www.healthvault.com). Accessed April 3, 2008.
43. Revolution Health Web site. Available at: (http://www.revolutionhealth. com). Accessed April 14, 2008.
44. Emory Healthcare. Your Personal Health Record. Available at: (http://www.emoryhealthcare.org/patient-guide/health-record-intro.html). Accessed April 3, 2008.
45. Vanderbilt University Medical Center. My-Medi-Health. Available at: (http://www.mc.vanderbilt.edu/root/vumc.php?site=mymedihealth). Accessed April 3, 2008.
46. Tang PC, Ash JS, Bates DW, Overhage JM, Sands DZ. Personal health records: Definitions, benefits, and strategies for overcoming barriers to adoption. J Am Med Inform Assoc. 2006;13:121-126.
47. myMDVIP Personal Web site. Available at: (http://mdvip.com/ NewCorpWebsite/VeryImportantPatients/PersonalHealthWebsiteDemonstration.aspx). Accessed April 3, 2008.
48. Pope JE, Hudson LR, Orr PM. Case study of American Healthways' diabetes disease management program. Health Care Financ Rev. 2005;27:47-58. (Pubitemid 41689115)
49. Duke University Health System. Duke Prospective Health. Available at: (http://www.dukeprospectivehealth.org). Accessed April 3, 2008.
50. Michalka E, Grantham P. Cure for health? Results show Duke Prospective Health pays off. INSIDE Duke Medicine. 2007;16. Available at: (http://www.inside.duke.edu/article.php?IssueID=177&ParentID=17019). Accessed April 3, 2008.
51. Your Plan for Health. Available at: (http://www.yourplanforhealth.com/ plan.html). Accessed April 3, 2008.
52. Personalized Medicine Coalition Web site. Available at: (http://www.personalizedmedicinecoalition.org). Accessed April 3, 2008.
53. Deverka PA, Doksum T, Carlson RJ. Integrating molecular medicine into the US health-care system: Opportunities, barriers, and policy challenges. Clin Pharmacol Ther. 2007;82:427-434. (Pubitemid 47414350)
54. Personalized Medicine Coalition. PMC members. Available at: (http://www.personalizedmedicinecoalition.org/about/pmc-members.php). Accessed April 3, 2008.
55. Obama introduces bill to help tap power of genomics to find cures. Available at: (http://obama.senate.gov/press/060809-obama-introduce-9). Accessed April 3, 2008.
56. The Blue Ridge Academic Health Group. Reforming Medical Education: Urgent Priority for the Academic Health Center in the New Century. Available at: (http://www.whsc.emory.edu/blueridge/-pdf/blue-ridge-report-7-2003may.pdf). Accessed April 3, 2008.
57. Association for Prevention Teaching and Research. Inventory of Knowledge and Skills Relating to Disease Prevention and Health Promotion. Available at: (http://www.aptrweb.org/resources/pdfs/Inventory.pdf). Accessed July 31, 2007.
58. Association of American Medical Colleges. Curriculum Directory. Available at: (http://www.services.aamc.org/currdir/section4/start.cfm). Accessed July 31, 2007.
59. Duke University School of Medicine, Medical school goals and objectives. Available at: (http://medschool.duke.edu/wysiwyg/downloads/GoalsObjectives.pdf). Accessed June 5, 2008.
60. Herzlinger RE. Where are the innovators in health care? Wall Street Journal. July 19, 2007:A15.
61. Association of American Medical Colleges. AAMC president's address 2004: "Promising change" [press release]. November 7, 2004. Available at: (http://www.aamc.org/newsroom/pressrel/2004/041107.htm). Accessed January 20, 2008.
62. McGinnis JM. Can public health and medicine partner in the public interest? Health Aff (Millwood). 2006;25:1044-1052.
63. Wagner ED, Bennett SM, Austin BT, Greene SM, Schaefer JK, Vonkorff M. Finding common ground: Patient-centeredness and evidence-based chronic illness care. J Altern Complement Med. 2005;11(suppl 1):S7-S15. (Pubitemid 43004964)
64. Kass NE, Medley AM, Natowicz MR, et al. Access to health insurance: Experiences and attitudes of those with genetic versus nongenetic medical condition. Am J Med Genet A. 2007;143:707-717.
65. Plantinga L, Natowicz MR, Kass NE, Hull SC, Gostin LO, Faden RR. Disclosure, confidentiality, and families: Experiences and attitudes of those with genetic versus nongenetic medical conditions. Am J Med Genet C Semin Med Genet. 2003;119:51-59. (Pubitemid 37064101)
66. Agency for Healthcare Research and Quality. AHRQ launches new "effective health care program" to compare medical treatments and help put proven treatments into practice. Available at: (http://www.ahrq.gov/news/ press/pr2005/effectivepr.htm). Accessed April 3, 2008.
67. Watkins RD. An Encyclopedia of Compelling Quotations. Peabody, Mass: Hendrickson Publishers; 2001.