Gender differences in methionine accumulation and metabolism in freshly isolated mouse hepatocytes: Potential roles in toxicity

Toxicology and Applied Pharmacology

Volumn 236, Issue 3, 2009, Pages 358-365

  Dever, Joseph T ^a   Elfarra, Adnan A ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Methionine; Methionine sulfoxide reduction; S adenosylmethionine; Sulfoxidation; Transamination; Transmethylation

Indexed keywords

AMINOOXYACETIC ACID; GLUTAMINE PHENYLPYRUVATE AMINOTRANSFERASE; METHIONINE; METHIONINE SULFOXIDE; S ADENOSYLMETHIONINE;

ANIMAL CELL; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; FEMALE; GENDER; LIVER TOXICITY; MALE; METABOLISM; METHYLATION; MOUSE; NONHUMAN; TRANSAMINATION;

AMINES; ANIMALS; FEMALE; HEPATOCYTES; MALE; METHIONINE; MICE; SEX FACTORS;

EID: 63649153407     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.02.009     Document Type: Article

References (31)

1. Baric I., Fumic K., Cuk M., Schulze A., Finkelstein J.D., James J., et al. S-Adenosylhomocysteine hydrolase deficiency in a human: a genetic disorder of methionine metabolism. Proc. Natl. Acad. Sci. 101 (2004) 4234-4239
2. Blom H.J., Boers G., Tribels J., van Roessel J., and Tangerman A. Cystathionine-synthase-deficient patients do not use the transamination pathway of methionine to reduce hypermethionemia and homocystineria. Metabolism 38 (1989) 577-582
3. Chiang P.K., Richards H.H., and Cantoni G.L. S-Adenosyl-l-homocysteine hydrolase: analogues of S-adenosyl-l-homocysteine as potential inhibitors. Mol. Pharmacol. 13 (1977) 939-947
4. Cooper A.J.L., and Meister A. Isolation and properties of a new glutamine transaminase from rat kidney. J. Biol. Chem. 249 (1974) 2554-2561
5. Cooper A.J.L., and Pinto J.T. Aminotransferase, l-amino acid oxidase and β-lyase reactions involving l-cysteine S-conjugates found in allium extracts: relevance to biological activity?. Biochem. Pharmacol. 69 (2005) 209-220
6. Cox R., Martin J.T., and Shinozuka H. Studies on acute methionine toxicity. II. Inhibition of ribonucleic acid synthesis in guinea pig liver by methionine and ethionine. Lab. Invest. 29 (1973) 54-59
7. Dever J.T., and Elfarra A.A. In vivo metabolism of l-methionine in mice: evidence for stereoselective formation of methionine-d-sulfoxide and quantitation of other major metabolites. Drug Metab. Dispos. 34 (2006) 2036-2043
8. Dever J.T., and Elfarra A.A. l-Methionine toxicity in freshly isolated mouse hepatocytes is gender-dependent and mediated in part by transamination. J. Pharmacol. Exp. Ther. 326 (2008) 809-817
9. Dever J.T., and Elfarra A.A. l-Methionine-dl-sulfoxide metabolism and toxicity in freshly isolated mouse hepatocytes: gender differences and inhibition with aminooxyacetic acid. Drug Metab. Dispos. 36 (2008) 2252-2260
10. Finkelstein J.D. Methionine metabolism in mammals. J. Nutr. Biochem. 1 (1990) 228-237
11. Finkelstein J.D. Methionine metabolism in liver diseases. Am. J. Clin. Nutr. 77 (2003) 1094-1095
12. Gahl W.A., Bernardini I., Finkelstein J.D., Tangerman A., Martin J.J., Blom H.J., et al. Transsulfuration in an adult with hepatic methionine adenosyltransferase deficiency. J. Clin. Invest. 81 (1988) 390-397
13. Grimaud R., Ezratz B., Mitchell J.K., Lafitte D., Briand C., Derrick P.J., et al. Repair of oxidized proteins. J. Biol. Chem. 276 (2001) 48915-48920
14. Heyman M.B., Tseng H.C., and Thaler M.M. Total parenteral nutrition decreases hepatic glutathione concentration in weanling rats. [Abstract]. Hepatology 4 (1984) 1049
15. Hissin P.J., and Hilf R. Effects of estrogen to alter amino acid transport in R3230AC mammary carcinomas and its relationship to insulin action. Cancer Res. 39 (1979) 3381-3387
16. Lee B.C., Le D.T., and Gladyshev V.N. Mammals reduce methionine-S-sulfoxide with MsrA, are unable to reduce methionine-R-sulfoxide, and this function can be restored with a yeast reductase. J. Biol. Chem. 283 (2008) 28361-28369
17. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
18. Lu S.C., Alvarez L., Huang Z.Z., Chen L., An W., Corrales F.J., et al. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc. Natl. Acad. Sci. 98 (2001) 5560-5565
19. Marfey P. Determination of d-amino acids. II. Use of a bifunctional reagent, 1,5-difluoro-2,4-dinitrobenzene. Carlsberg Res. Commun. 49 (1984) 591-596
20. Martinez-chantar M.L., Corrales F.J., Martinez-Cruz L.A., Garcia-Trevijano E.R., Huang Z., Chen L., et al. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A. FASEB J. 16 (2002) 1292-1294
21. Mato J.M., Corrales F.J., Lu S.C., and Avila M.A. S-Adenosylmethionine: a control switch that regulates liver function. FASEB J. 16 (2002) 15-26
22. Matthews R.H., and Zand R. Methionine transport in S37 cells: substrate-dependent function of amino acid transport system A in exchange processes. Biochim. Biophys. Acta 554 (1979) 227-233
23. Mitchell A.D., and Benevenga N.J. The role of transamination in methionine oxidation in the rat. J. Nutr. 108 (1978) 67-78
24. Mori N., and Hirayama K. Long-term consumption of methionine-supplemented diet increases iron and lipid peroxide levels in rat liver. J. Nutr. 130 (2000) 2349-2355
25. Moskovitz J., Poston J.M., Berlett B.S., Nosworthy N.J., Szczepanowski R., and Stadtman E.R. Identification and characterization of a putative active site for peptide methionine sulfoxide reductase (MsrA) and its substrate stereospecificity. J. Biol. Chem. 275 (2000) 14167-14172
26. Moskovitz J., Singh V.K., Requena J., Wilkinson B.J., Jayaswal R.K., and Stadtman E.R. Purification and characterization of methionine sulfoxide reductases from mouse and Staphylococcus aureus and their substrate stereospecificity. Biochem. Biophys. Res. Commun. 290 (2002) 62-65
27. Moss R.L., Haynes A.L., Pastuszyn A., and Glew R.H. Methionine infusion reproduces liver injury of parenteral nutrition cholestasis. Pediatr. Res. 45 (1999) 664-668
28. Ripp S.L., Itagaki K., Philpot R.M., and Elfarra A.A. Methionine S-oxidation in human and rabbit liver microsomes: evidence for a high-affinity methionine S-oxidase activity that is distinct from flavin-containing monooxygenase 3. Arch. Biochem. Biophys. 367 (1999) 322-332
29. Shinozuka H., Estes L.W., and Farber E. Studies on acute methionine toxicity. I. Nucleolar disaggregation in guinea pig hepatic cells with methionine or ethionine and its reversal with adenine. Am. J. Pathol. 64 (1971) 241-249
30. Tangerman A., Wilcken B., Levy H.L., Boers G.H.J., and Mudd S.H. Methionine transamination in patients with homocystinuria due to cystathionine β-synthase deficiency. Metabolism 49 (2000) 1071-1077
31. Wise C.K., Cooney C.A., Ali S.F., and Poirier L.A. Measuring S-adenosylmethionine in whole blood, red blood cells and cultured cells using a fast preparation method and high-performance liquid chromatography. J. Chromatogr., B. 696 (1997) 145-152