Inhibitory effect of baicalin on disaccharidase in small intestine

Chinese Journal of Natural Medicines

Volumn 7, Issue 2, 2009, Pages 129-133

  Gu, Shu Jing ^a   Liu, Li ^a   Liu, Yao Wu ^a   Jing, Xin Yue ^a   Liu, Xiao Dong ^a   Xie, Lin ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Baicalin(BA); Diabetes; Disaccharidase; Intestine; Sucrase

Indexed keywords

ACARBOSE; ALPHA GLUCOSIDASE; BAICALIN; CARBOXYMETHYLCELLULOSE; DISACCHARIDASE; SODIUM; SUCRASE; SUCROSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AQUEOUS SOLUTION; ARTICLE; BODY WEIGHT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MEGADOSE; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; GLUCOSE BLOOD LEVEL; IN VITRO STUDY; INTESTINE BRUSH BORDER; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; RAT; SMALL INTESTINE; STREPTOZOCIN DIABETES; TREATMENT DURATION;

EID: 63649145754     PISSN: 20956975     EISSN: 18755364     Source Type: Journal    
DOI: 10.3724/SP.J.1009.2009.00129     Document Type: Article

References (15)

1. Lebovitz HE. Alpha-glucosidase inhibitors [J]. Endocrinol Metab Clin North Am, 1997, 26: 539-551.
2. Levin RJ. Digestion and absorption of carbohydrates - from molecules and membranes to humans [J]. Am J Clin Nutr, 1994, 59(3 Suppl):690S-698S.
3. Adachi T, Mori C, Sakurai K, et al. Morphological changes and increased sucrase and isomaltase activity in small intestines of insulin-deficient and type 2 diabetic rats [J]. Endocr J, 2003, 50(3):271-279.
4. Murakami I, Ikeda T. Effects of diabetes and hyperglycemia on disaccharidase activities in rats [J]. Scand J Gastroenterol, 1998, 33(10): 1069-1073.
5. Oh WK, Lee CH, Lee MS, et al. Antidiabetic effects of extracts from Psidium guajava [J]. J Ethnopharmacol, 2005, 96(3): 411-415.
6. Youn JY, Park HY, ChoKH. Anti- hyperglycemic activity of Commelina communis L.: inhibition of alpha-glucosidase [J]. Diabetes Res Clin Pract, 2004, 66(1 Suppl): S149-S155.
7. Li Y, Wen S, Kota BP, Peng G, et al. Punica granatum flower extract, a potent alpha-glucosidase inhibitor, improves postprandial hyperglycemia in Zucker diabetic fatty rats [J]. J Ethnopharmacol, 2005, 99(2): 239-244.
8. Wu S, Sun A, Liu R. Separation and purification of baicalin and wogonoside from the Chinese medicinal plant Scutellaria baicalensis Georgi by high-speed counter-current chromatography [J]. J Chromato A, 2005, 1066: 243-247.
9. Suh KS, Nam YH, Ahn YM. Effect of Scutellariae Radix extract on the high glucose-induced apoptosis in culture vacular endothelial cells [J]. Biol Pharm Bull, 2003, 26(11): 1629-1632.
10. Part SM, Hong SM, Sung SR, et al. Extracts of Rehmanniae radix, Ginseng radix and Scutellariae Radix improve glucose-stimulated insulin secretion and beta-cell proliferation through IRS2 induction [J]. Genes Nutr, 2008, 2(4): 347-351.
11. Gao H, Hua YN, et al. Inhibitory effect on α-glucosidase by Adhatoda vasica Nees [J]. Food Chem, 2008, 108: 965-972.
12. Liu L, Deng YX, Yu S, et al. Berberine attenuated intestinal disaccharidases in streptozotocin-induced diabetic rats [J]. Die Pharmazie, 2008, 63(5): 384-388.
13. Truong TN, Nguyen VC. Anti-hyperglycemic activity of an aqueous extract from flower buds of Cleistocalyx operculatus (Roxb.) Merr and Perry [J].Biosci Biotechnol Biochem, 2007, 71(1): 69-76.
14. Campbell LK, BakerDE, Campbell RK. Migolitol: assessment og its role in the treatment of patients with diabetes mellitus [J]. Ann Pharmacother, 2000, 34(11): 1291-1301.
15. Cai WW, Meng JW, Wang YQ, et al. Metabolism of the treatment of Radix scutellariae to diabetic complications [J] (Chinese). Chin Pharm, 2008, 19(12): 947-949.