Activation of the lytic program of the Epstein-Barr virus in Burkitt's lymphoma cells leads to a two steps downregulation of expression of the proapoptotic protein BimEL, one of which is EBV-late-gene expression dependent

Virology

Volumn 387, Issue 1, 2009, Pages 41-49

  Oussaief, Lassad ^a,b   Hippocrate, Aurélie ^a   Clybouw, Cyril ^a   Rampanou, Aurore ^a   Ramirez, Vanessa ^a,d   Desgranges, Claude ^c   Vazquez, Aimé ^a   Khelifa, Ridha ^b   Joab, Irène ^a  

^a UNIVERSITÉ PARIS SACLAY   (France)

^b HABIB THAMEUR HOSPITAL   (Tunisia)

^c INSTITUT COCHIN   (France)

^d UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

BimEL; Burkitt's lymphoma; EBV; Reactivation

Indexed keywords

APOPTOTIC PROTEIN BIMEL; BIM PROTEIN; HYDROLASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEASOME; SERINE; SERINE 69; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BURKITT LYMPHOMA; CANCER CELL CULTURE; CELL CYCLE; CONTROLLED STUDY; ENZYME ACTIVATION; EPSTEIN BARR VIRUS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; LYMPHOMA CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; VIRUS REACTIVATION;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BORONIC ACIDS; BURKITT LYMPHOMA; BUTADIENES; CELL LINE, TUMOR; DOWN-REGULATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 4, HUMAN; HUMANS; MEMBRANE PROTEINS; NITRILES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS; VIRUS ACTIVATION;

HUMAN HERPESVIRUS 4;

EID: 63549146318     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.02.009     Document Type: Article

References (21)

1. Arbach H., Viglasky V., Lefeu F., Guinebretière J.M., Ramirez V., Bride N., Boualaga N., Bauchet T., Peyrat J.P., Mathieu M.C., Mourah S., Podgorniak M.P., Seignerin J.M., Takada K., and Joab I. Epstein-Barr virus (EBV) genome and expression in breast cancer tissue: effect of EBV infection of breast cancer cells on resistance to paclitaxel (Taxol). J. Virol. 80 (2006) 845-853
2. Altmann M., and Hammerschmidt W. Epstein-Barr virus provides a new paradigm: a requirement for the immediate inhibition of apoptosis. PLoS Biol. 3 (2005) 2148-2157
3. Ben-Bassat H., Goldblum N., Mitrani S., Goldblum T., Yoffey J.M., Cohen M.M., Bentwich Z., Ramot B., Klein E., and Klein G. Establishment in continuous culture of a new type of lymphocyte from a "Burkitt like" malignant lymphoma (line D.G.-75). Int. J. Cancer 19 (1977) 27-33
4. Clybouw C., McHichi B., Mouhamad S., Auffredou M.T., Bourgeade M.F., Sharma S., Leca G., and Vazquez A. EBV infection of human B lymphocytes leads to downregulation of Bim expression: relationship to resistance to apoptosis. J. Immunol. 175 (2005) 2968-2973
5. Clybouw C., Mchichi B.E., Hadji A., Portier A., Auffredou M.T., Arnoult D., Leca G., and Vazquez A. TGFbeta-mediated apoptosis of Burkitt's lymphoma BL41 cells is associated with the relocation of mitochondrial BimEL. Oncogene 27 (2008) 3446-3456
6. El Mchichi B., Hadji A., Vazquez A., and Leca G. p38 MAPK and MSK1 mediate caspase-8 activation in manganese-induced mitochondria-dependent cell death. Cell Death Differ. 14 (2007) 1826-1836
7. Fahmi H., Cochet C., Hmama Z., Opolon P., and Joab I. Transforming growth factor beta 1 stimulates expression of the Epstein-Barr virus BZLF1 immediate-early gene product ZEBRA by an indirect mechanism which requires the MAPK kinase pathway. J. Virol. 74 (2000) 5810-5818
8. Feederle R., Kost M., Baumann M., Janz A., Drouet E., Hammerschmidt W., and Delecluse H. The Epstein-Barr virus lytic program is controlled by the co-operative functions of two transactivators. EMBO J. 19 (2000) 3080-3089
9. Gregory C.D., Rowe M., and Rickinson A.B. Different Epstein-Barr virus-B cell interactions in phenotypically distinct clones of a Burkitt's lymphoma cell line. J. Gen. Virol. 71 (1990) 1481-1495
10. Howell M., Williams T., and Hazlewood S.A. Herpesvirus pan encodes a functional homologue of BHRF1, the Epstein-Barr virus v-Bcl-2. BMC Microbiol. 5 (2005) 6
11. Inman G.J., Binné U.K., Parker G.A., Farrell P.J., and Allday M.J. Activators of the Epstein-Barr virus lytic program concomitantly induce apoptosis, but lytic gene expression protects from cell death. J. Virol. 75 (2001) 2400-2410
12. Klein G., Lindahl T., Jondal M., Leibold W., Menézes J., Nilsson K., and Sundström C. Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas. Proc. Natl. Acad. Sci. U. S. A. 7 (1974) 3283-3286
13. Kieff E., and Rickinson A.B. Epstein-Barr virus and its replication 5th ed. In: Fields Howley P.M., and Knipe D.M. (Eds). Field's Virology 2 (2007), Lippincott, Williams & Wilkins Publishers, Philadelphia 2602-2700
14. Ley R., Balmanno K., Hadfield K., Weston C., and Cook S.J. Activation of the ERK 1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J. Biol. Chem. 278 (2003) 18811-18816
15. Luciano F., Jacquel A., Colosetti P., Herrant M., Cagnol S., Pages G., and Auberger P. Phosphorylation of Bim-EL by ERK 1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function. Oncogene 22 (2003) 6785-6793
16. Pattle S.B., and Farrell P.J. The role of Epstein-Barr virus in cancer. Expert Opin. Biol. Ther. 6 (2006) 1193-1205
17. Takada K. Cross-linking of cell surface immunoglobulins induces Epstein-Barr virus in Burkitt lymphoma lines. Int. J. Cancer 33 (1984) 27-32
18. Takada K., Horinouchi K., Ono Y., Aya T., Osato T., Takahashi M., and Hayasaka S. An Epstein-Barr virus-producer line Akata: establishment of the cell line and analysis of viral DNA. Virus Genes 5 (1991) 147-156
19. Touitou R., Arbach H., Cochet C., Feuillard J., Martin A., Raphaël M., and Joab I. Heterogeneous Epstein-Barr virus latent gene expression in AIDS-associated lymphomas and in type I Burkitt's lymphoma cell lines. J. Gen. Virol. 84 (2003) 949-957
20. Yuan J., Cahir-McFarland E., Zhao B., and Kieff E. Virus and cell RNAs expressed during Epstein-Barr virus replication. J. Virol. 80 (2006) 2548-2565
21. Zur Hausen H., O'Neill F.J., Freese K., and Hecker E. Persisting oncogenic herpesvirus induced by the tumor promoter TPA. Nature 272 (1978) 373-375