Involvement of GRP78 in inhibition of HBV secretion by Boehmeria nivea extract in human HepG2 2.2.15 cells

Journal of Viral Hepatitis

Volumn 16, Issue 5, 2009, Pages 367-375

  Huang, K L ^b   Lai, Y K ^b,c   Lin, C C ^b   Chang, Jia Ming ^a  

^a Development Centre for Biotechnology   (Taiwan)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^c DA YEH UNIVERSITY   (Taiwan)

Author keywords

Endoplasmic reticulum; GRP78; HBV surface protein; Hepatitis B virus secretion; Herbal; SiRNA

Indexed keywords

BOEHMERIA NIVEA EXTRACT; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; LAMIVUDINE; PLANT EXTRACT; THAPSIGARGIN; UNCLASSIFIED DRUG; VIRUS DNA;

ANTIVIRAL ACTIVITY; ARTICLE; BOEHMERIA NIVEA; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENTIATION; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAMIE; VIRUS CORE;

ANTIVIRAL AGENTS; BOEHMERIA; CELL LINE; DNA, VIRAL; GENE KNOCKDOWN TECHNIQUES; HEAT-SHOCK PROTEINS; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; MOLECULAR CHAPERONES; PLANT EXTRACTS; VIRUS REPLICATION;

EID: 63549117253     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2009.01072.x     Document Type: Article

References (34)

1. Lesmana LA, Leung NW, Mahachai V et al. Hepatitis B: overview of the burden of disease in the Asia-Pacific region. Liver Int 2006 26 (Suppl. 2 3 10.
2. Kamimura T, Yoshikawa A, Ichida F, Sasaki H. Electron microscopic studies of Dane particles in hepatocytes with special reference to intracellular development of Dane particles and their relation with HBeAg in serum. Hepatology 1981 1 (5 392 397.
3. Patzer EJ, Nakamura GR, Simonsen CC, Levinson AD, Brands R. Intracellular assembly and packaging of hepatitis B surface antigen particles occur in the endoplasmic reticulum. J Virol 1986 58 (3 884 892.
4. Cattaneo R, Will H, Hernandez N, Schaller H. Signals regulating hepatitis B surface antigen transcription. Nature 1983 305 (5932 336 338.
5. Bruss V. Hepatitis B virus morphogenesis. World J Gastroenterol 2007 13 (1 65 73.
6. Bruss V, Lu X, Thomssen R, Gerlich WH. Post-translational alterations in transmembrane topology of the hepatitis B virus large envelope protein. EMBO J 1994 13 (10 2273 2279.
7. Prange R, Streeck RE. Novel transmembrane topology of the hepatitis B virus envelope proteins. EMBO J 1995 14 (2 247 256.
8. Ostapchuk P, Hearing P, Ganem D. A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis. EMBO J 1994 13 (5 1048 1057.
9. Urban S, Gripon P. Inhibition of duck hepatitis B virus infection by a myristoylated pre-S peptide of the large viral surface protein. J Virol 2002 76 (4 1986 1990.
10. Gripon P, Cannie I, Urban S. Efficient inhibition of hepatitis B virus infection by acylated peptides derived from the large viral surface protein. J Virol 2005 79 (3 1613 1622.
11. Ueda K, Tsurimoto T, Matsubara K. Three envelope proteins of hepatitis B virus: large S, middle S, and major S proteins needed for the formation of Dane particles. J Virol 1991 65 (7 3521 3529.
12. Persing DH, Varmus HE, Ganem D. Inhibition of secretion of hepatitis B surface antigen by a related presurface polypeptide. Science 1986 234 (4782 1388 1391.
13. Ou JH, Rutter WJ. Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein. J Virol 1987 61 (3 782 786.
14. Xu Z, Jensen G, Yen TS. Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum. J Virol 1997 71 (10 7387 7392.
15. Xu Z, Bruss V, Yen TS. Formation of intracellular particles by hepatitis B virus large surface protein. J Virol 1997 71 (7 5487 5494.
16. Chisari FV, Filippi P, McLachlan A et al. Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice. J Virol 1986 60 (3 880 887.
17. He B. Viruses, endoplasmic reticulum stress, and interferon responses. Cell Death Differ 2006 13 (3 393 403.
18. Patil C, Walter P. Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals. Curr Opin Cell Biol 2001 13 (3 349 355.
19. Chen LY, Chiang AS, Hung JJ, Hung HI, Lai YK. Thapsigargin-induced grp78 expression is mediated by the increase of cytosolic free calcium in 9L rat brain tumor cells. J Cell Biochem 2000 78 (3 404 416.
20. Lee AS. The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods 2005 35 (4 373 381.
21. Cho DY, Yang GH, Ryu CJ, Hong HJ. Molecular chaperone GRP78/BiP interacts with the large surface protein of hepatitis B virus in vitro and in vivo. J Virol 2003 77 (4 2784 2788.
22. Lambert C, Prange R. Chaperone action in the posttranslational topological reorientation of the hepatitis B virus large envelope protein: Implications for translocational regulation. Proc Natl Acad Sci U S A 2003 100 (9 5199 5204.
23. Prange R, Werr M, Loffler-Mary H. Chaperones involved in hepatitis B virus morphogenesis. Biol Chem 1999 380 (3 305 314.
24. Werr M, Prange R. Role for calnexin and N-linked glycosylation in the assembly and secretion of hepatitis B virus middle envelope protein particles. J Virol 1998 72 (1 778 782.
25. Huang KL, Lai YK, Lin CC, Chang JM. Inhibition of hepatitis B virus production by Boehmeria nivea root extract in HepG2 2.2.15 cells. World J Gastroenterol 2006 12 (35 5721 5725.
26. Chang J-M, Huang K-L, Yuan TT-T, Lai Y-K, Hung L-M The anti-hepatitis B virus activity of Boehmeria nivea extract in HBV-viremia SCID mice. eCAM 2008 : doi :.
27. Zu K, Bihani T, Lin A, Park YM, Mori K, Ip C. Enhanced selenium effect on growth arrest by BiP/GRP78 knockdown in p53-null human prostate cancer cells. Oncogene 2006 25 (4 546 554.
28. Ying C, Li Y, Leung CH, Robek MD, Cheng YC. Unique antiviral mechanism discovered in anti-hepatitis B virus research with a natural product analogue. Proc Natl Acad Sci USA 2007 104 (20 8526 8531.
29. Chua PK, Wang RY, Lin MH, Masuda T, Suk FM, Shih C. Reduced secretion of virions and hepatitis B virus (HBV) surface antigen of a naturally occurring HBV variant correlates with the accumulation of the small S envelope protein in the endoplasmic reticulum and Golgi apparatus. J Virol 2005 79 (21 13483 13496.
30. Hu J, Flores D, Toft D, Wang X, Nguyen D. Requirement of heat shock protein 90 for human hepatitis B virus reverse transcriptase function. J Virol 2004 78 (23 13122 13131.
31. Park SG, Lee SM, Jung G. Antisense oligodeoxynucleotides targeted against molecular chaperonin Hsp60 block human hepatitis B virus replication. J Biol Chem 2003 278 (41 39851 39857.
32. Bartholomeusz A, Locarnini S. Hepatitis B virus mutations associated with antiviral therapy. J Med Virol 2006 78 (Suppl. 1 S52 S55.
33. Sheldon J, Rodes B, Zoulim F, Bartholomeusz A, Soriano V. Mutations affecting the replication capacity of the hepatitis B virus. J Viral Hepat 2006 13 (7 427 434.
34. Malhotra JD, Kaufman RJ. The endoplasmic reticulum and the unfolded protein response. Semin Cell Dev Biol 2007 18 (6 716 731.