Prediction of outcome after paraquat poisoning by measurement of the plasma paraquat concentration

QJM: An International Journal of Medicine

Volumn 102, Issue 4, 2009, Pages 251-259

  Senarathna, L ^a   Eddleston, M ^a,b,c   Wilks, M F ^d   Woollen, B H ^e   Tomenson, J A ^f   Roberts, D M ^a,g   Buckley, Nick A ^a,g,h,i  

^a UNIVERSITY OF PERADENIYA   (Sri Lanka)

^b ROYAL INFIRMARY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d SYNGENTA CROP PROTECTION AG   (Switzerland)

^e JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^f Causation Ltd   (United Kingdom)

^g The Australian National University   (Australia)

^h UNIVERSITY OF NEW SOUTH WALES   (Australia)

ⁱ UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED CARBON; CYCLOPHOSPHAMIDE; FULLER EARTH; PARAQUAT; PREDNISOLONE;

ADULT; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DEATH; FEMALE; FOLLOW UP; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; PARAQUAT POISONING; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; SENSITIVITY AND SPECIFICITY; SRI LANKA; STOMACH LAVAGE; SURVIVAL RATE; TANDEM MASS SPECTROMETRY; VOMITING;

EID: 63549098064     PISSN: 14602725     EISSN: 14602393     Source Type: Journal    
DOI: 10.1093/qjmed/hcp006     Document Type: Article

References (21)

1. Lock EA, Wilks MF. Paraquat. In: Handbook of Pesticide Toxicology, 2nd edn. San Diego, Academic Press, 2001:1559-603.
2. Eddleston M. Patterns and problems of deliberate self-poisoning in the developing world. QJM 2000; 93:715-31.
3. Eddleston M, Wilks MF, Buckley NA. Prospects for treatment of paraquat-induced lung fibrosis with immunosuppressive drugs and the need for better prediction of outcome: A systematic review. QJM 2003; 96:809-24.
4. Jones AL, Elton R, Flanagan R. Multiple logistic regression analysis of plasma paraquat concentrations as a predictor of outcome in 375 cases of paraquat poisoning. QJM 1999; 92:573-8.
5. Proudfoot AT, Stewart MS, Levitt T, Widdop B. Paraquat poisoning: significance of plasma-paraquat concentrations. Lancet 1979; 2 330-2.
6. Scherrmann JM, Houze P, Bismuth C, Bourdon R. Prognostic value of plasma and urine paraquat concentration. Hum Toxicol 1987; 6:91-3.
7. Hart TB, Nevitt A, Whitehead A. A new statistical approach to the prognostic significance of plasma paraquat concentrations. Lancet 1984; 2:1222-3.
8. Sawada Y, Yamamoto I, Hirokane T, Nagai Y, Satoh Y, Ueyama M. Severity index of paraquat poisoning. Lancet 1988; 1:1333.
9. Gil HW, Kang MS, Yang JO, Lee EY, Hong SY. Association between plasma paraquat level and outcome of paraquat poisoning in 375 paraquat poisoning patients. Clin Toxicol 2008; 46:515-8.
10. Wilks MF, Fernando R, Ariyananda PL, Eddleston M, Berry DJ, Tomenson JA, et al. Improvement in survival after paraquat ingestion following introduction of a new formulation in Sri Lanka. PLoS Med 2008; 5:e49.
11. Eddleston M, Juszczak E, Buckley NA, Senarathna L, Mohamed F, Dissanayake W, et al. Multiple-dose activated charcoal in acute self-poisoning: A randomised controlled trial. Lancet 2008; 371 579-87.
12. Blake DK, Gallagher RT, Woollen BH. Improved methods for the analysis of paraquat in biological fluids. Chromatographia 2002; 55 (Suppl.) S183-5.
13. Attia J. Moving beyond sensitivity and specificity: Using likelihood ratios to help interpret diagnostic tests. Aust Prescriber 2003; 26:111-3.
14. Heylings JR, Farnworth MJ, Swain CM, Clapp MJ, Elliott BM. Identification of an alginate-based formulation of paraquat to reduce the exposure of the herbicide following oral ingestion. Toxicology 2007; 241:1-10.
15. Eddleston M, Haggalla S, Reginald K, Sudarshan K, Senthilkumaran M, Karalliedde L, et al. The hazards of gastric lavage for intentional self-poisoning in a resource poor location. Clin Toxicol (Phila) 2007; 45:136-43.
16. Houze P, Baud FJ, Mouy R, Bismuth C, Bourdon R, Scherrmann JM. Toxicokinetics of paraquat in humans. Hum Exp Toxicol JID - 9004560 1990; 9:5-12.
17. Eddleston M, Dissanayake M, Sheriff MH, Warrell DA, Gunnell D. Physical vulnerability and fatal self-harm in the elderly. Br J Psychiatry 2006; 189:278-9.
18. Ackrill P, Hasleton PS, Ralston AJ. Oesophageal perforation due to paraquat. Br Med J 1978; 1:1252-3.
19. Wilks MF, Tomenson JA, Buckley NA, Dawson AH. Influence of gastric decontamination on patient outcome after paraquat ingestion. Asia Pacific Association of Medical Toxicology (APAMT) meeting. Bangkok, 2007. [http://www.evosof.com/asiatox/papers/Influence of gastric decontamination on patient outcome after paraquat ingestion.pdf. 2007] Accessed 7 January 2009.
20. Eddleston M, Sudarshan K, Senthilkumaran M, Reginald K, Karalliedde L, Senarathna L, et al. Patterns of hospital transfer for self-poisoned patients in rural Sri Lanka: Implications for estimating the incidence of self-poisoning in the developing world. Bull World Health Organ 2006; 84:276-82.
21. Carley S, Dosman S, Jones SR, Harrison M. Simple nomograms to calculate sample size in diagnostic studies. Emerg Med J 2005; 22 180-1.