The 5′UTR-specific mutation in VEEV TC-83 genome has a strong effect on RNA replication and subgenomic RNA synthesis, but not on translation of the encoded proteins

Virology

Volumn 387, Issue 1, 2009, Pages 211-221

  Kulasegaran Shylini, Raghavendran ^a   Thiviyanathan, Varatharasa ^a   Gorenstein, David G ^a   Frolov, Ilya ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

5 UTR; Alphavirus; Attenuating mutation; NMR; RNA secondary structure; RNA synthesis; Virus replication

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; VIRUS PROTEIN; VIRUS RNA;

5' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; DOWN REGULATION; IN VITRO STUDY; MICROBIAL ATTENUATION; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; RNA REPLICATION; RNA SYNTHESIS; RNA TRANSCRIPTION; RNA TRANSLATION; VENEZUELAN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS; VIRUS GENOME; VIRUS MUTATION; VIRUS REPLICATION; VIRUS STRAIN; ANIMAL; BIOSYNTHESIS; CELL LINE; CELL STRAIN 3T3; GENE EXPRESSION REGULATION; GENETICS; HAMSTER; METABOLISM; PATHOGENICITY; PROTEIN SYNTHESIS;

ALPHAVIRUS; TOGAVIRIDAE; VENEZUELAN EQUINE ENCEPHALITIS VIRUS;

5' UNTRANSLATED REGIONS; ANIMALS; CELL LINE; CRICETINAE; ENCEPHALITIS VIRUS, VENEZUELAN EQUINE; GENE EXPRESSION REGULATION, VIRAL; GENOME, VIRAL; MICE; NIH 3T3 CELLS; PROTEIN BIOSYNTHESIS; RNA, VIRAL; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 63549096251     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.02.027     Document Type: Article

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