DRD2 C32806T modifies the effect of child-rearing environment on adulthood novelty seeking

American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics

Volumn 150, Issue 3, 2009, Pages 389-394

  Keltikangas Järvinen, Liisa ^a   Pulkki Råback, Laura ^a   Elovainio, Marko ^b   Raitakari, Olli T ^c   Viikari, Jorma ^c   Lehtimäki, Terho ^d,e  

^a UNIVERSITY OF HELSINKI   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

^e TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

Dopamine; DRD2; Gene x environment interaction; Hostile child rearing; Novelty seeking

Indexed keywords

DOPAMINE 2 RECEPTOR;

ADOLESCENT; ADULT; ADULTHOOD; ALLELE; ARTICLE; BEHAVIOR GENETICS; CHILD; CHILD REARING; CONTROLLED STUDY; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; ALLELES; CHILD; CHILD REARING; COHORT STUDIES; ENVIRONMENT; EXPLORATORY BEHAVIOR; FAMILY RELATIONS; FEMALE; GENOTYPE; HUMANS; LONGITUDINAL STUDIES; MALE; MOTHERS; POLYMORPHISM, GENETIC; RECEPTORS, DOPAMINE D2;

EID: 63449128468     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/ajmg.b.30830     Document Type: Article

References (34)

1. Anderson KE, Lytton H, Romney DM. 1986. Mothers' interactions with normal and conduct-disordered boys: Who affects whom? Dev Psychol 22:604-609.
2. Bartrés-Faz D, Junqué C, Serra-Grabulosa JM, López-alomar A, Moya A, Bargalló N, Mercader JM, Moral P, Clemente IC. 2002. Dopamine DRD2 Taq I polymorphism associates with caudate nucleus volume and cognitive performance in memory impaired subjects. Neuroreport 13:1121-1125.
3. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. 1996. Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking. Nat Genet 12:81-84.
4. Berman SM, Noble EP. 1997. The D2 dopamine receptor (DRD2) gene and family stress; interactive effects on cognitive functions in children. Behav Genet 27:33-43.
5. Berman SM, Ozkaragoz T, Noble EP, Antolin T, Sheen C, Siddarth P, Conner BT, Ritchie T. 2003. Differential associations of sex and D2 dopamine receptor (DRD2) genotype with negative affect and other substance abuse risk markers in children of alcoholics. Alcohol 30:201-210.
6. Caspi A, McClay J, Moffitt TE, Mill J, Martin J, Craig IW, Taylor A, Poulton R. 2002. Role of genotype in the cycle of violence in maltreated children. Science 297:851-854.
7. Cloninger CR, Svrakic DM, Przybeck TR. 1993. A psychobiological model of temperament and character. Arch Gen Psychiatry 50:975-990.
8. Conner BT, Noble EP, Berman SM, Ozkaragoz T, Ritchie T, Antolin T, Sheen C. 2005. DRD2 genotypes and substance use in adolescent children of alcoholics. Drug Alcohol Depend 79:379-387.
9. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, Bennett ER, Nemanov L, Katz M, Belmaker RH. 1996. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking. Nat Genet 12:78-80.
10. Ekelund J, Lichtermann D, Järvelin M-R, Peltonen L. 1999. Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample. Am J Psychiatry 156:1453-1455.
11. Elovainio M, Jokela M, Kivimäki M, Pulkki-RåbackL, Lehtimäki T, Airla N, Keltikangas-Järvinen L. 2007. Genetic variants in the DRD2 gene moderate the relationship between stressful life events and depressive symptoms in adults: Cardiovascular risk in young Finns study. PsychosomMed 69:391-395.
12. Foley DL, Eaves LJ, Wormley B, Silberg JL, Maes HH, Kuhn J, Riley B. 2004. Childhood adversity, monoamine oxidase a genotype, and risk for conduct disorder. Arch Gen Psychiatry 61:738-744.
13. Gelernter J, Kranzler H, Coccaro E, Siever L, New A, MulgrewCL. 1997. D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects. Am J Hum Genet 61:1144-1152.
14. Herbst JH, Zonderman AB, McCrae RR, Costa PT Jr. 2000. Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis. Am J Psychiatry 157:1285-1290.
15. Juonala M, Viikari JS, Hutri-Kahonen N, Pietikainen M, Jokinen E, Taittonen L, Marniemi J, Ronnemaa T, Raitakari OT. 2004. The 21-year follow-up of the Cardiovascular Risk in Young Finns Study: Risk factor levels, secular trends and east-west difference. J Intern Med 255:457-468.
16. Keltikangas-Järvinen L, Puttonen S. 2001. Temperament and stress reactivity. Paper presented at: Congress of Developmental Psychology, August 2001, Helsinki, Finland.
17. Keltikangas-Järvinen L, Ravaja N, Viikari J. 1999. Identifying Cloningeŕs temperament profiles as related to the early development of the metabolic cardiovascular syndrome in young men. Arterioscler Thromb Vasc Biol 19:1998-2006.
18. Keltikangas-Järvinen L, Räikkönen K, Ekelund J, Peltonen L. 2004. Nature and nurture in novelty seeking. Mol Psychiatry 9:308-311.
19. Keltikangas-Järvinen L, Elovainio M, Kivimäki M, Raitakari OT, Viikari JS, Lehtimäki T. 2007. Dopamine receptor D2 gene Taq1A (C32806T) polymorphism modifies the relationship between birth weight and educational attainment in adulthood: 21-year follow-up of the Cardiovascular Risk in Young Finns Study. Pediatrics 120:756-761.
20. Lahti J, Röaikkönen K, Ekelund J, Peltonen L, Raitakari OT, Keltikangas-Järvinen L. 2006. Socio-demographic characteristics moderate the association between DRD4 and novelty seeking. Pers Individ Differ 40:533-543.
21. Lee CL, Bates JE. 1985. Mother-child interaction at age two years and perceived difficult temperament. Child Dev 56:1314-1325.
22. Light KJ, Joyce PR, Luty SE, Mulder RT, Carter JD, Frampton CM, Miller AL, Kennedy MA. 2007. An association study of DRD2 and COMT polymorphisms with novelty seeking and harm avoidance scores, in two independent samples of depressed patients. Behav Brain Funct 3:3.
23. Livak KJ. 1999. Allelic discrimination using fluorogenic probes and the 5' nuclease assay. Genet Anal 14:143-149.
24. Lucht M, Barnow S, Schroeder W, Grabe HJ, Finckh U, John U, Freyberger HJ, Herrmann FH. 2006. Negative perceived paternal parenting is associated with dopamine D2 receptor exon 8 and GABA(A) alpha 6 receptor variants: An explorative study. Am J Med Genet Part B 141B:167-172.
25. Madrid GA, MacMurray J, Lee JW, Anderson BA, Comings DE. 2001. Stress as a mediating factor in the association between the DRD2 TaqI poly-morphmism and alcoholism. Alcohol 23:117-122.
26. Makkonen T, Ruoppila I, Rönkä T, Timonen S, Valvanne L, O?sterlund K. 1981. Operaatio perhe-is ä ja synnytys: Tutkimus perhesynnytyksestä, vierihoidosta ja esikoisperheen vuorovaikutuksesta. Lapsiraportti A 34.
27. [Operation family. Child report, No. A. 34]. Helsinki: Mannerheim League of Child Welfare.
28. Malhotra AK, Virkkunen M, Rooney W, Eggert M, Linnoila M, Goldman D. 1996. The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking. Mol Psychiatry 1:388-391.
29. Mills-Koonce WR, Propper CB, Gariepy JL, Blair C, Garrett-Peters P, Cox MJ. 2007. Bidirectional genetic and environmental influences on mother and child behavior: The family system as the unit of analyses. Dev Psychopathol 19:1073-1087.
30. Noble EP, Ozkaragoz TZ, Ritchie TL, ZhangX, Belin TR, Sparkes RS. 1998. D2 and D4 dopamine receptor polymorphisms and personality. Am J Med Genet 81:257-267.
31. Ono Y, Manki H, Yoshimura K, Muramatsu T, Mizushima H, Higuchi S, Yagi G, Kanba S, Asai M. 1997. Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects. Am J Med Genet 74:501-503.
32. Ozkaragoz T, Noble EP. 2000. Extraversion. Interaction between D2 dopamine receptor polymorphisms and parental alcoholism. Alcohol 22:139-146.
33. Szekely A, Ronai Z, Nemoda Z, Kolmann G, Gervai J, Sasvari-Szekely M. 2004. Human personality dimensions ofpersistence and harm avoidance associated with DRD4 and 5-HTTLPR polymorphisms. Am J Med Genet Part B 126B:106-110.
34. Thompson J, Thomas N, Singleton A, Piggott M, Lloyd S, Perry EK, Morris CM, Perry RH, Ferrier IN, Court JA. 1997. D2 dopamine receptor gene (DRD2) Taq1 A polymorphism: Reduced dopamine D2 receptor binding in the human striatum associated with the A1 allele. Pharmacogenetics 7:479-484.