Anti-inflammatory Effect of Peroxisome Proliferator Activated Receptor Gamma on Human Dental Pulp Cells

Journal of Endodontics

Volumn 35, Issue 4, 2009, Pages 524-528

  Yu, Mi Kyung ^a   Lee, Jung Chang ^a   Kim, Jeong Hee ^a   Lee, Young Hee ^a   Jeon, Jae Gyu ^a   Jhee, Eun Chung ^a   Yi, Ho Keun ^a  

^a Chonbuk National University   (South Korea)

Author keywords

Human dental pulp cells; ICAM 1; MMP 2; MMP 9; PPAR gamma; pulpal inflammation; VCAM 1

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 2-CHLORO-5-NITROBENZANILIDE; ANILIDE; ANTIINFLAMMATORY AGENT; AUTACOID; GELATINASE A; GELATINASE B; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RECOMBINANT PROTEIN; ROSIGLITAZONE; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG ANTAGONISM; DRUG POTENTIATION; ESCHERICHIA COLI; FIBROBLAST; HUMAN; METABOLISM; PHYSIOLOGY; PULPITIS; TOOTH PULP; WESTERN BLOTTING;

ANILIDES; ANTI-INFLAMMATORY AGENTS; BLOTTING, WESTERN; CELLS, CULTURED; DENTAL PULP; ESCHERICHIA COLI; FIBROBLASTS; HUMANS; INFLAMMATION MEDIATORS; INTERCELLULAR ADHESION MOLECULE-1; LIPOPOLYSACCHARIDES; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PPAR GAMMA; PULPITIS; RECOMBINANT PROTEINS; THIAZOLIDINEDIONES; VASCULAR CELL ADHESION MOLECULE-1;

EID: 63449106116     PISSN: 00992399     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joen.2008.12.012     Document Type: Article

References (29)

1. Love R.M., and Jenkinson H.F. Invasion of dentinal tubules by oral bacteria. Crit Rev Oral Biol Med 13 (2002) 171-183
2. Rupf S., Kannengiesser S., Merte K., Pfister W., Sigusch B., and Eschrich K. Comparison of profiles of key periodontal pathogens in periodontium and endodontium. Endod Dent Traumatol 16 (2000) 269-275
3. Santos M.C., de Souza A.P., Gerlach R.F., Trevilatto P.C., Scarel-Caminaga R.M., and Line S.R. Inhibition of human pulpal gelatinases (MMP-2 and MMP-9) by zinc oxide cements. J Oral Rehabil 31 (2004) 660-664
4. Takada H., Mihara J., Morisaki I., and Hamada S. Induction of interleukin-1 and -6 in human gingival fibroblast cultures stimulated with Bacteroides lipopolysaccharides. Infect Immun 59 (1991) 295-301
5. Zachlederova M., and Jarolim P. The dynamics of gene expression in human lung microvascular endothelial cells after stimulation with inflammatory cytokines. Physiol Res 55 (2006) 39-47
6. Lee J.C., Yu M.K., Lee R., et al. Terrein reduces pulpal inflammation in human dental pulp cells. J Endod 34 (2008) 433-437
7. Kota B.P., Huang T.H., and Roufogalis B.D. An overview on biological mechanisms of PPARs. Pharmacol Res 51 (2005) 85-94
8. Tontonoz P., Hu E., and Spiegelman B.M. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell 79 (1994) 1147-1156
9. Chinetti G., Griglio S., Antonucci M., et al. Activation of proliferator-activated receptors alpha and gamma induces apoptosis of human monocyte-derived macrophages. J Biol Chem 273 (1998) 25573-25580
10. Gelman L., Fruchart J.C., and Auwerx J. An update on the mechanisms of action of the peroxisome proliferator-activated receptors (PPARs) and their roles in inflammation and cancer. Cell Mol Life Sci 55 (1999) 932-943
11. Jiang C., Ting A.T., and Seed B. PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391 (1998) 82-86
12. Shiojiri T., Wada K., Nakajima A., et al. PPAR gamma ligands inhibit nitrotyrosine formation and inflammatory mediator expressions in adjuvant-induced rheumatoid arthritis mice. Eur J Pharmacol 448 (2002) 231-238
13. Lee K.S., Park S.J., Hwang P.H., et al. PPAR-gamma modulates allergic inflammation through up-regulation of PTEN. FASEB J 19 (2005) 1033-1035
14. Lee S., Kim W., Kang K.P., et al. Agonist of peroxisome proliferator-activated receptor-gamma, rosiglitazone, reduces renal injury and dysfunction in a murine sepsis model. Nephrol Dial Transplant 20 (2005) 1057-1065
15. Gaillard V., Casellas D., Seguin-Devaux C., et al. Pioglitazone improves aortic wall elasticity in a rat model of elastocalcinotic arteriosclerosis. Hypertension 46 (2005) 372-379
16. Yi H.K., Kim S.Y., Hwang P.H., et al. Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells. Biochem Biophys Res Commun 13 (2005) 760-767
17. Khabbaz M.G., Anastasiadis P.L., and Sykaras S.N. Determination of endotoxins in the vital pulp of human carious teeth: association with pulpal pain. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91 (2001) 587-593
18. Sawa Y., Yoshida S., Shibata K.I., Suzuki M., and Mukaida A. Vascular endothelium of human dental pulp expresses diverse adhesion molecules for leukocyte emigration. Tissue Cell 30 (1998) 281-291
19. Palosaari H., Pennington C.J., Larmas M., Edwards D.R., Tjaderhane L., and Salo T. Expression profile of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in mature human odontoblasts and pulp tissue. Eur J Oral Sci 111 (2003) 117-127
20. Ingman T., Tervahartiala T., Ding Y., et al. Matrix metalloproteinases and their inhibitors in gingival crevicular fluid and saliva of periodontitis patients. J Clin Periodontol 23 (1996) 1127-1132
21. van der Zee E., Everts V., and Beertsen W. Cytokine-induced endogenous procollagenase stored in the extracellular matrix of soft connective tissue results in a burst of collagen breakdown following its activation. J Periodont Res 3 (1996) 483-488
22. Sutinen M., Kainulainen T., Hurskainen T., et al. Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasis. Br J Cancer 77 (1998) 2239-2245
23. Greenwald R.A., Golub L.M., Ramamurthy N.S., Chowdhury M., Moak S.A., and Sorsa T. In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation. Bone 22 (1998) 33-38
24. Dayan D., Binderman I., and Mechanic G.L. A preliminary study of activation of collagenase in carious human dentin matrix. Arch Oral Biol 28 (1983) 185-187
25. Tjaderhane L., Larjava H., Sorsa T., Uitto V.J., Larmas M., and Salo T. The activation and function of host matrix metalloproteinases in dentin matrix breakdown in caries lesions. J Dent Res 77 (1998) 1622-1629
26. O'Boskey F.J., and Panagakos F.S. Cytokines stimulate matrix metalloproteinase production by human pulp cells during long-term culture. J Endod 24 (1998) 7-10
27. Corbel M., Belleguic C., Boichot E., and Lagente V. Involvement of gelatinases (MMP-2 and MMP-9) in the development of airway inflammation and pulmonary fibrosis. Cell Biol Toxicol 18 (2002) 51-61
28. Tsai C.H., Chen Y.J., Huang F.M., Su Y.F., and Chang Y.C. The upregulation of matrix metalloproteinase-9 in inflamed human dental pulps. J Endod 31 (2005) 860-862
29. Chang Y.C., Yang S.F., and Hsieh Y.S. Regulation of matrix metalloproteinase-2 production by cytokines and pharmacological agents in human pulp cell cultures. J Endod 27 (2001) 679-682