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Volumn 12, Issue 2, 2009, Pages 89-95

Cardiac rhabdomyomas in tuberous sclerosis complex show apoptosis regulation and mTOR pathway abnormalities

Author keywords

Apoptosis; Cardiac tumor; mTOR signaling; Tuberous sclerosis complex

Indexed keywords

HAMARTIN; INITIATION FACTOR 4E BINDING PROTEIN 1; KI 67 ANTIGEN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOAKT PROTEIN; PHOSPHOEXTRACELLULAR SIGNAL REGULATED MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; S6 KINASE; S6 KINASE 1; TUBERIN; UNCLASSIFIED DRUG;

EID: 63449100787     PISSN: 10935266     EISSN: 16155742     Source Type: Journal    
DOI: 10.2350/06-11-0191.1     Document Type: Article
Times cited : (36)

References (26)
  • 1
    • 0033917658 scopus 로고    scopus 로고
    • Selected aspects of cardiac tumors in infancy and childhood
    • Freedom RM, Lee KJ, MacDonald C, Taylor G. Selected aspects of cardiac tumors in infancy and childhood. Pediatr Cardiol 2000;21: 299-316.
    • (2000) Pediatr Cardiol , vol.21 , pp. 299-316
    • Freedom, R.M.1    Lee, K.J.2    MacDonald, C.3    Taylor, G.4
  • 2
    • 0033918266 scopus 로고    scopus 로고
    • Primary heart tumors in the pediatric age group: A review of salient pathologic features relevant for clinicians
    • Becker AE. Primary heart tumors in the pediatric age group: a review of salient pathologic features relevant for clinicians. Pediatr Cardiol 2000;21:317-323.
    • (2000) Pediatr Cardiol , vol.21 , pp. 317-323
    • Becker, A.E.1
  • 3
    • 33644539200 scopus 로고    scopus 로고
    • Multiple cardiac rhabdomyomas as a sole symptom of tuberous sclerosis complex: Case report with molecular confirmation
    • Jozwiak S, Domańska-Pakieła D, Kwiatkowski DJ, Kotulska K. Multiple cardiac rhabdomyomas as a sole symptom of tuberous sclerosis complex: case report with molecular confirmation. J Child Neurol 2005;20:988-989.
    • (2005) J Child Neurol , vol.20 , pp. 988-989
    • Jozwiak, S.1    Domańska-Pakieła, D.2    Kwiatkowski, D.J.3    Kotulska, K.4
  • 4
    • 0042063774 scopus 로고    scopus 로고
    • Association between cardiac tumors and tuberous sclerosis in the fetus and neonate
    • Tworetzky W, McElhinney DB, Margossian R, et al. Association between cardiac tumors and tuberous sclerosis in the fetus and neonate. Am J Cardiol 2003;92:487-489.
    • (2003) Am J Cardiol , vol.92 , pp. 487-489
    • Tworetzky, W.1    McElhinney, D.B.2    Margossian, R.3
  • 5
    • 33750097361 scopus 로고    scopus 로고
    • Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex
    • Jóźwiak S, Kotulska K, Kasprzyk-Obara J, et al. Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex. Pediatrics 2006;118:1146-1151.
    • (2006) Pediatrics , vol.118 , pp. 1146-1151
    • Jóźwiak, S.1    Kotulska, K.2    Kasprzyk-Obara, J.3
  • 7
    • 0035167932 scopus 로고    scopus 로고
    • Mutational analysis in a cohort of 224 Tuberous Sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
    • Dabora SL, JoZwiak S, Franz DN, et al. Mutational analysis in a cohort of 224 Tuberous Sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet 2001;68:64-80.
    • (2001) Am J Hum Genet , vol.68 , pp. 64-80
    • Dabora, S.L.1    JoZwiak, S.2    Franz, D.N.3
  • 8
    • 0030064630 scopus 로고    scopus 로고
    • Morbidity associated with tuberous sclerosis: Apopulationstudy
    • Webb DW, Fryer AE, Osborne JP. Morbidity associated with tuberous sclerosis: apopulationstudy. DevMedChildNeurol 1996;38:146-155.
    • (1996) DevMedChildNeurol , vol.38 , pp. 146-155
    • Webb, D.W.1    Fryer, A.E.2    Osborne, J.P.3
  • 9
    • 1842733405 scopus 로고    scopus 로고
    • Natural history and long-term outcome of cardiac rhabdomyomas detected prenatally
    • Fesslova V Villa L, Rizzuti T, Mastrangelo M., Mosca F. Natural history and long-term outcome of cardiac rhabdomyomas detected prenatally. Prenat Diagn 2004;24:241-248.
    • (2004) Prenat Diagn , vol.24 , pp. 241-248
    • Fesslova, V.1    Villa, L.2    Rizzuti, T.3    Mastrangelo, M.4    Mosca, F.5
  • 10
    • 0026096189 scopus 로고
    • Causes of death in patients with tuberous sclerosis
    • Shepherd CW, Gomez MR, Crowson CS. Causes of death in patients with tuberous sclerosis. Mayo Clin Proc 1991;66:792-796.
    • (1991) Mayo Clin Proc , vol.66 , pp. 792-796
    • Shepherd, C.W.1    Gomez, M.R.2    Crowson, C.S.3
  • 11
    • 29244481490 scopus 로고    scopus 로고
    • Jóźwiak J, Jóźwiak S, Grzela T, Łazarczyk M. Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway. Neuromolecular Med 2005;7:287-296.
    • Jóźwiak J, Jóźwiak S, Grzela T, Łazarczyk M. Positive and negative regulation of TSC2 activity and its effects on downstream effectors of the mTOR pathway. Neuromolecular Med 2005;7:287-296.
  • 13
    • 24044466187 scopus 로고    scopus 로고
    • Tuberous sclerosis: Immunohistochemistry expression of tuberin and hamartin in a 31-week gestational fetus
    • Vinaitheerthan M, Wei J, Mizuguchi M, Greco A, Barness AG. Tuberous sclerosis: immunohistochemistry expression of tuberin and hamartin in a 31-week gestational fetus. Fetal Pediatr Pathol 2004;23: 241-249.
    • (2004) Fetal Pediatr Pathol , vol.23 , pp. 241-249
    • Vinaitheerthan, M.1    Wei, J.2    Mizuguchi, M.3    Greco, A.4    Barness, A.G.5
  • 14
    • 0036759970 scopus 로고    scopus 로고
    • Tuberous sclerosis in a 19-week fetus: Immunohistochemical and molecular study of hamartin and tuberin
    • Wei J, Li P, Chiriboga L, et al. Tuberous sclerosis in a 19-week fetus: immunohistochemical and molecular study of hamartin and tuberin. Pediatr Dev Pathol 2002;5:448-464.
    • (2002) Pediatr Dev Pathol , vol.5 , pp. 448-464
    • Wei, J.1    Li, P.2    Chiriboga, L.3
  • 15
    • 0030853223 scopus 로고    scopus 로고
    • Tuberin immunohistochemistry in brain, kidneys and heart with or without tuberous sclerosis
    • Mizuguchi M, Kato M, Yamanouchi H, Ikeda K, Takashima S. Tuberin immunohistochemistry in brain, kidneys and heart with or without tuberous sclerosis. Acta Neuropathol 1997;94:25-31.
    • (1997) Acta Neuropathol , vol.94 , pp. 25-31
    • Mizuguchi, M.1    Kato, M.2    Yamanouchi, H.3    Ikeda, K.4    Takashima, S.5
  • 16
    • 18544375193 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
    • Dan HC, Sun M, Yang L, et al. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem 2002;277:35364-35370.
    • (2002) J Biol Chem , vol.277 , pp. 35364-35370
    • Dan, H.C.1    Sun, M.2    Yang, L.3
  • 17
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
    • Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 2005;121:179-193.
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 18
    • 24744435392 scopus 로고    scopus 로고
    • Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/ extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum
    • Wlodarski P, Kasprzycka M, Liu X, et al. Activation of mammalian target of rapamycin in transformed B lymphocytes is nutrient dependent but independent of Akt, mitogen-activated protein kinase/ extracellular signal-regulated kinase kinase, insulin growth factor-I, and serum. Cancer Res 2005;65:7800-7808.
    • (2005) Cancer Res , vol.65 , pp. 7800-7808
    • Wlodarski, P.1    Kasprzycka, M.2    Liu, X.3
  • 19
    • 0034634282 scopus 로고    scopus 로고
    • Apoptosis during cardiovascular development
    • Fisher SA, Langille BL, Srivastava D. Apoptosis during cardiovascular development. Circ Res 2000;87:856-864.
    • (2000) Circ Res , vol.87 , pp. 856-864
    • Fisher, S.A.1    Langille, B.L.2    Srivastava, D.3
  • 20
    • 0033564419 scopus 로고    scopus 로고
    • Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptation to chronic pressure overload in the rat
    • Condorelii G, Morisco C, Stassi G, et al. Increased cardiomyocyte apoptosis and changes in proapoptotic and antiapoptotic genes bax and bcl-2 during left ventricular adaptation to chronic pressure overload in the rat. Circulation 1999;99:3071-3078.
    • (1999) Circulation , vol.99 , pp. 3071-3078
    • Condorelii, G.1    Morisco, C.2    Stassi, G.3
  • 21
    • 0034075609 scopus 로고    scopus 로고
    • Upregulation of the Bcl-2 family of proteins in end stage of heart failure
    • Latif N, Khan MA, Birks E, et al. Upregulation of the Bcl-2 family of proteins in end stage of heart failure. J Am Coll Cardiol 2000;35: 1769-1777.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 1769-1777
    • Latif, N.1    Khan, M.A.2    Birks, E.3
  • 22
    • 0032575688 scopus 로고    scopus 로고
    • The Bcl-2 protein family: Arbiters of cell survival
    • Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998;281:1322-1326.
    • (1998) Science , vol.281 , pp. 1322-1326
    • Adams, J.M.1    Cory, S.2
  • 23
    • 33750206088 scopus 로고    scopus 로고
    • Tuberin activates the proapoptotic molecule BAD
    • Freilinger A, Rosner M, Krupitza G, et al. Tuberin activates the proapoptotic molecule BAD. Oncogene 2006;25:6467-6479.
    • (2006) Oncogene , vol.25 , pp. 6467-6479
    • Freilinger, A.1    Rosner, M.2    Krupitza, G.3
  • 24
    • 33745098277 scopus 로고    scopus 로고
    • Tuberin negatively affects BCL-2's cell survival function
    • Freilinger A, Rosner M, Hengstschlager M. Tuberin negatively affects BCL-2's cell survival function. Amino Acids 2006;30:391-396.
    • (2006) Amino Acids , vol.30 , pp. 391-396
    • Freilinger, A.1    Rosner, M.2    Hengstschlager, M.3
  • 25
    • 33644827461 scopus 로고    scopus 로고
    • Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
    • Franz DN, Leonard J, Tudor C, et al. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann Neurol 2006;59: 490-498.
    • (2006) Ann Neurol , vol.59 , pp. 490-498
    • Franz, D.N.1    Leonard, J.2    Tudor, C.3
  • 26
    • 33644689608 scopus 로고    scopus 로고
    • Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment
    • Jóźwiak J, Jóźwiak S, Ołdak M. Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment. Med Res Rev 2006;26:160-180.
    • (2006) Med Res Rev , vol.26 , pp. 160-180
    • Jóźwiak, J.1    Jóźwiak, S.2    Ołdak, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.